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Nmt2 N-myristoyltransferase 2 [ Mus musculus (house mouse) ]

Gene ID: 18108, updated on 12-May-2024

Summary

Official Symbol
Nmt2provided by MGI
Official Full Name
N-myristoyltransferase 2provided by MGI
Primary source
MGI:MGI:1202298
See related
Ensembl:ENSMUSG00000026643 AllianceGenome:MGI:1202298
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
hNMT-2; A930001K02Rik
Summary
Predicted to enable glycylpeptide N-tetradecanoyltransferase activity. Predicted to be involved in N-terminal peptidyl-glycine N-myristoylation. Predicted to act upstream of or within N-terminal protein myristoylation. Predicted to be located in Golgi apparatus; cytosol; and plasma membrane. Predicted to be extrinsic component of membrane. Predicted to be active in cytoplasm. Is expressed in early conceptus; embryo; liver; lung; and spinal cord. Orthologous to human NMT2 (N-myristoyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in frontal lobe adult (RPKM 16.8), CNS E18 (RPKM 14.5) and 25 other tissues See more
Orthologs
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Genomic context

See Nmt2 in Genome Data Viewer
Location:
2 A1; 2 1.84 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (3285249..3329914)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (3284212..3328877)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03510 Neighboring gene family with sequence similarity 171, member A1 Neighboring gene predicted gene, 54098 Neighboring gene STARR-seq mESC enhancer starr_03511 Neighboring gene predicted gene, 22005 Neighboring gene STARR-positive B cell enhancer ABC_E999 Neighboring gene ribonuclease P/MRP 38 subunit Neighboring gene acyl-Coenzyme A binding domain containing 7 Neighboring gene oleoyl-ACP hydrolase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables glycylpeptide N-tetradecanoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glycylpeptide N-tetradecanoyltransferase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables glycylpeptide N-tetradecanoyltransferase activity TAS
Traceable Author Statement
more info
PubMed 
enables peptidyl-lysine N6-myristoyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glycylpeptide N-tetradecanoyltransferase 2
Names
myristoyl-CoA:protein N-myristoyltransferase 2
peptide N-myristoyltransferase 2
type II N-myristoyltransferase
NP_001277297.1
NP_001277298.1
NP_001277299.1
NP_032734.1
XP_036015249.1
XP_036015250.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290368.1NP_001277297.1  glycylpeptide N-tetradecanoyltransferase 2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site that results in translation initiation at an alternate start codon and a frameshifted 5' coding region, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AK161490, AL732620, AL928883
    Conserved Domains (2) summary
    pfam01233
    Location:133287
    NMT; Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
    pfam02799
    Location:303478
    NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain
  2. NM_001290369.1NP_001277298.1  glycylpeptide N-tetradecanoyltransferase 2 isoform c

    See identical proteins and their annotated locations for NP_001277298.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon that results in translation initiation at an alternate start codon and a frameshifted 5' coding region, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AK134521, AL732620, AL928883
    Consensus CDS
    CCDS70972.1
    UniProtKB/TrEMBL
    F7APP3
    Related
    ENSMUSP00000089085.5, ENSMUST00000091504.5
    Conserved Domains (2) summary
    pfam01233
    Location:127281
    NMT; Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
    pfam02799
    Location:297472
    NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain
  3. NM_001290370.1NP_001277299.1  glycylpeptide N-tetradecanoyltransferase 2 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate exons that result in the loss of an in-frame segment in the 5' coding region, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
    Source sequence(s)
    AK134521, AL732620, AL928883
    Consensus CDS
    CCDS70971.1
    UniProtKB/TrEMBL
    A2AJH3
    Related
    ENSMUSP00000100054.4, ENSMUST00000102989.10
    Conserved Domains (2) summary
    pfam01233
    Location:140294
    NMT; Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
    pfam02799
    Location:310485
    NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain
  4. NM_008708.2NP_032734.1  glycylpeptide N-tetradecanoyltransferase 2 isoform a

    See identical proteins and their annotated locations for NP_032734.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AK134521, AL732620, AL928883
    Consensus CDS
    CCDS15644.1
    UniProtKB/Swiss-Prot
    O70311
    UniProtKB/TrEMBL
    Q3THR4
    Related
    ENSMUSP00000080600.7, ENSMUST00000081932.13
    Conserved Domains (2) summary
    pfam01233
    Location:171325
    NMT; Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
    pfam02799
    Location:341516
    NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    3285249..3329914
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159357.1XP_036015250.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X2

    Conserved Domains (1) summary
    COG5092
    Location:22389
    NMT1; N-myristoyl transferase [Lipid metabolism]
  2. XM_036159356.1XP_036015249.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X1

    Conserved Domains (1) summary
    COG5092
    Location:55422
    NMT1; N-myristoyl transferase [Lipid metabolism]