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    NEK9 NIMA related kinase 9 [ Homo sapiens (human) ]

    Gene ID: 91754, updated on 17-Jun-2024

    Summary

    Official Symbol
    NEK9provided by HGNC
    Official Full Name
    NIMA related kinase 9provided by HGNC
    Primary source
    HGNC:HGNC:18591
    See related
    Ensembl:ENSG00000119638 MIM:609798; AllianceGenome:HGNC:18591
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NC; APUG; NERCC; LCCS10; NERCC1
    Summary
    This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein is activated in mitosis and, in turn, activates other family members during mitosis. This protein also mediates cellular processes that are essential for interphase progression. [provided by RefSeq, Jul 2016]
    Expression
    Ubiquitous expression in ovary (RPKM 24.4), testis (RPKM 21.8) and 25 other tissues See more
    Orthologs
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    Genomic context

    See NEK9 in Genome Data Viewer
    Location:
    14q24.3
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (75079353..75127202, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (69288752..69338522, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (75546056..75593751, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 689, pseudogene Neighboring gene mutL homolog 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5939 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8735 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:75535987-75536538 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:75536539-75537090 Neighboring gene acylphosphatase 1 Neighboring gene zinc finger C2HC-type containing 1C Neighboring gene ReSE screen-validated silencer GRCh37_chr14:75565767-75565964 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8736 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8737 Neighboring gene HIF1AP pseudogene 1 Neighboring gene transmembrane p24 trafficking protein 10 Neighboring gene Sharpr-MPRA regulatory regions 714 and 744 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75619067-75619731 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:75643139-75643711 Neighboring gene RNA, U4atac small nuclear 14, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of NIMA-related kinase 9 (NEK9) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC16714, MGC138306, DKFZp434D0935

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    colocalizes_with centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase Nek9
    Names
    NIMA (never in mitosis gene a)- related kinase 9
    nercc1 kinase
    nimA-related protein kinase 9
    NP_001316166.1
    NP_001316167.1
    NP_149107.4
    XP_005268266.1
    XP_047287875.1
    XP_054232953.1
    XP_054232954.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051093.2 RefSeqGene

      Range
      5154..52849
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001329237.2NP_001316166.1  serine/threonine-protein kinase Nek9 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL049780
      Consensus CDS
      CCDS91908.1
      UniProtKB/TrEMBL
      A0A7I2V5R1
      Related
      ENSP00000504620.1, ENST00000678037.1
      Conserved Domains (3) summary
      smart00220
      Location:52308
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08221
      Location:51308
      STKc_Nek9; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 9
      pfam00415
      Location:444495
      RCC1; Regulator of chromosome condensation (RCC1) repeat
    2. NM_001329238.2NP_001316167.1  serine/threonine-protein kinase Nek9 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL049780
      Consensus CDS
      CCDS91907.1
      UniProtKB/TrEMBL
      A0A7I2V454
      Related
      ENSP00000503827.1, ENST00000678531.1
    3. NM_033116.6NP_149107.4  serine/threonine-protein kinase Nek9 isoform 2

      See identical proteins and their annotated locations for NP_149107.4

      Status: REVIEWED

      Source sequence(s)
      AL049780
      Consensus CDS
      CCDS9839.1
      UniProtKB/Swiss-Prot
      Q52LK6, Q8NCN0, Q8TCY4, Q8TD19, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6
      Related
      ENSP00000238616.5, ENST00000238616.10
      Conserved Domains (3) summary
      smart00220
      Location:52308
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08221
      Location:51308
      STKc_Nek9; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 9
      pfam00415
      Location:500547
      RCC1; Regulator of chromosome condensation (RCC1) repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      75079353..75127202 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047431919.1XP_047287875.1  serine/threonine-protein kinase Nek9 isoform X2

      UniProtKB/TrEMBL
      A0A7I2V454
      Related
      ENSP00000504104.1, ENST00000678749.1
    2. XM_005268209.4XP_005268266.1  serine/threonine-protein kinase Nek9 isoform X1

      Conserved Domains (2) summary
      cl21453
      Location:1190
      PKc_like; Protein Kinases, catalytic domain
      cl27697
      Location:227582
      RCC1; Regulator of chromosome condensation (RCC1) repeat

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      69288752..69338522 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054376979.1XP_054232954.1  serine/threonine-protein kinase Nek9 isoform X2

    2. XM_054376978.1XP_054232953.1  serine/threonine-protein kinase Nek9 isoform X1