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    ZNF35 zinc finger protein 35 [ Homo sapiens (human) ]

    Gene ID: 7584, updated on 17-Jun-2024

    Summary

    Official Symbol
    ZNF35provided by HGNC
    Official Full Name
    zinc finger protein 35provided by HGNC
    Primary source
    HGNC:HGNC:13099
    See related
    Ensembl:ENSG00000169981 MIM:194533; AllianceGenome:HGNC:13099
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HF10; HF.10; Zfp105
    Summary
    Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in cellular response to retinoic acid; regulation of transcription by RNA polymerase II; and spermatogenesis. Located in nucleus and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis (RPKM 5.6), urinary bladder (RPKM 2.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZNF35 in Genome Data Viewer
    Location:
    3p21.31
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (44646506..44660791)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (44662214..44676499)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (44690224..44702283)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ZKSCAN7 ZNF cluster antisense RNA 1 Neighboring gene ZNF660-ZNF197 readthrough Neighboring gene zinc finger protein 660 Neighboring gene ZNF197 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14270 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:44666861-44667363 Neighboring gene zinc finger protein 197 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:44689909-44690468 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19768 Neighboring gene zinc finger protein 251 pseudogene Neighboring gene zinc finger protein OZF-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14271 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14272 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19769

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to retinoic acid ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    zinc finger protein 35
    Names
    zinc finger protein 35 (clone HF.10)
    zinc finger protein HF.10

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003420.4NP_003411.3  zinc finger protein 35

      See identical proteins and their annotated locations for NP_003411.3

      Status: VALIDATED

      Source sequence(s)
      AC099669, BC013597, BC015892, BP237260
      Consensus CDS
      CCDS2718.2
      UniProtKB/Swiss-Prot
      B2RBU6, P13682, Q53Y54, Q96D01
      Related
      ENSP00000379368.2, ENST00000396056.7
      Conserved Domains (4) summary
      COG5048
      Location:214369
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:336356
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:474496
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:488513
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      44646506..44660791
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047448870.1XP_047304826.1  zinc finger protein 35 isoform X1

      UniProtKB/Swiss-Prot
      B2RBU6, P13682, Q53Y54, Q96D01
    2. XM_047448869.1XP_047304825.1  zinc finger protein 35 isoform X1

      UniProtKB/Swiss-Prot
      B2RBU6, P13682, Q53Y54, Q96D01
    3. XM_047448866.1XP_047304822.1  zinc finger protein 35 isoform X1

      UniProtKB/Swiss-Prot
      B2RBU6, P13682, Q53Y54, Q96D01
    4. XM_047448867.1XP_047304823.1  zinc finger protein 35 isoform X1

      UniProtKB/Swiss-Prot
      B2RBU6, P13682, Q53Y54, Q96D01
    5. XM_047448868.1XP_047304824.1  zinc finger protein 35 isoform X1

      UniProtKB/Swiss-Prot
      B2RBU6, P13682, Q53Y54, Q96D01

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_009646197.1 Reference GRCh38.p14 PATCHES

      Range
      171860..186145
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331561.1XP_054187536.1  zinc finger protein 35 isoform X1

      UniProtKB/Swiss-Prot
      B2RBU6, P13682, Q53Y54, Q96D01
    2. XM_054331560.1XP_054187535.1  zinc finger protein 35 isoform X1

      UniProtKB/Swiss-Prot
      B2RBU6, P13682, Q53Y54, Q96D01
    3. XM_054331558.1XP_054187533.1  zinc finger protein 35 isoform X1

      UniProtKB/Swiss-Prot
      B2RBU6, P13682, Q53Y54, Q96D01
    4. XM_054331559.1XP_054187534.1  zinc finger protein 35 isoform X1

      UniProtKB/Swiss-Prot
      B2RBU6, P13682, Q53Y54, Q96D01
    5. XM_054331557.1XP_054187532.1  zinc finger protein 35 isoform X1

      UniProtKB/Swiss-Prot
      B2RBU6, P13682, Q53Y54, Q96D01

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      44662214..44676499
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054347767.1XP_054203742.1  zinc finger protein 35 isoform X1

      UniProtKB/Swiss-Prot
      B2RBU6, P13682, Q53Y54, Q96D01
    2. XM_054347766.1XP_054203741.1  zinc finger protein 35 isoform X1

      UniProtKB/Swiss-Prot
      B2RBU6, P13682, Q53Y54, Q96D01
    3. XM_054347764.1XP_054203739.1  zinc finger protein 35 isoform X1

      UniProtKB/Swiss-Prot
      B2RBU6, P13682, Q53Y54, Q96D01
    4. XM_054347765.1XP_054203740.1  zinc finger protein 35 isoform X1

      UniProtKB/Swiss-Prot
      B2RBU6, P13682, Q53Y54, Q96D01
    5. XM_054347763.1XP_054203738.1  zinc finger protein 35 isoform X1

      UniProtKB/Swiss-Prot
      B2RBU6, P13682, Q53Y54, Q96D01