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Zfp105 zinc finger protein 105 [ Mus musculus (house mouse) ]

Gene ID: 22646, updated on 2-Nov-2024

Summary

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Official Symbol
Zfp105provided by MGI
Official Full Name
zinc finger protein 105provided by MGI
Primary source
MGI:MGI:1277119
See related
Ensembl:ENSMUSG00000057895 AllianceGenome:MGI:1277119
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including blastocyst; branchial arch; genitourinary system; limb; and maxillary process. Orthologous to human ZNF35 (zinc finger protein 35). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis adult (RPKM 7.2), CNS E11.5 (RPKM 6.8) and 16 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp105 in Genome Data Viewer
Location:
9 F4; 9 73.23 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (122752105..122764325)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (122923039..122935260)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 445 Neighboring gene zinc finger with KRAB and SCAN domains 7 Neighboring gene zinc finger protein 660 Neighboring gene RIKEN cDNA 1110059G10 gene Neighboring gene STARR-seq mESC enhancer starr_25555 Neighboring gene STARR-seq mESC enhancer starr_25556 Neighboring gene kinesin family member 15 Neighboring gene predicted gene, 35691

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression of zinc finger protein 105 in the testis and its role in male fertility. Zhou H, et al. Mol Reprod Dev, 2010 Jun. PMID 20186958, Free PMC Article
  2. Differential expression of the zinc finger gene Zfp105 during spermatogenesis. Przyborski SA, et al. Mamm Genome, 1998 Sep. PMID 9716663
  3. Identification of early-responsive genes correlated to valproic acid-induced neural tube defects in mice. Okada A, et al. Birth Defects Res A Clin Mol Teratol, 2005 Apr. PMID 15799026
  4. High-throughput screen for genes predominantly expressed in the ICM of mouse blastocysts by whole mount in situ hybridization. Yoshikawa T, et al. Gene Expr Patterns, 2006 Jan. PMID 16325481, Free PMC Article
  5. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results suggest that ZFP105 is a male germ-cell factor and plays a role in male reproduction.
    Title: Expression of zinc finger protein 105 in the testis and its role in male fertility.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger protein 35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009544.2 → NP_033570.2  zinc finger protein 35

    See identical proteins and their annotated locations for NP_033570.2

    Status: VALIDATED

    Source sequence(s)
    AC125374, BC052165
    Consensus CDS
    CCDS23649.1
    UniProtKB/TrEMBL
    G3X9I0
    Related
    ENSMUSP00000079840.6, ENSMUST00000051667.14
    Conserved Domains (3) summary
    COG5048
    Location:209 → 366
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:333 → 353
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:485 → 510
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    122752105..122764325
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242959.4 → XP_011241261.1  zinc finger protein 35 isoform X1

    See identical proteins and their annotated locations for XP_011241261.1

    UniProtKB/TrEMBL
    G3X9I0
    Conserved Domains (3) summary
    COG5048
    Location:209 → 366
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:333 → 353
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:485 → 510
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version

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