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    SRP68 signal recognition particle 68 [ Homo sapiens (human) ]

    Gene ID: 6730, updated on 17-Jun-2024

    Summary

    Official Symbol
    SRP68provided by HGNC
    Official Full Name
    signal recognition particle 68provided by HGNC
    Primary source
    HGNC:HGNC:11302
    See related
    Ensembl:ENSG00000167881 MIM:604858; AllianceGenome:HGNC:11302
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SCN10
    Summary
    This gene encodes a subunit of the signal recognition particle (SRP). The SRP is a ribonucleoprotein complex that transports secreted and membrane proteins to the endoplasmic reticulum for processing. The complex includes a 7S RNA and six protein subunits. The encoded protein is the 68kDa component of the SRP, and forms a heterodimer with the 72kDa subunit that is required for SRP function. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and three pseudogenes of this gene are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, May 2012]
    Expression
    Ubiquitous expression in thyroid (RPKM 29.4), esophagus (RPKM 22.8) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See SRP68 in Genome Data Viewer
    Location:
    17q25.1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (76038785..76072517, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (76931916..76965649, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (74034866..74068598, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene TEN1-CDK3 readthrough (NMD candidate) Neighboring gene MPRA-validated peak3002 silencer Neighboring gene Sharpr-MPRA regulatory region 2383 Neighboring gene cyclin dependent kinase 3 Neighboring gene envoplakin Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74022969-74023856 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74030076-74030683 Neighboring gene Sharpr-MPRA regulatory region 345 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74036239-74036940 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74036941-74037642 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9001 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74067885-74068712 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74068713-74069540 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74070927-74071808 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74072691-74073571 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74075097-74076094 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74076095-74077090 Neighboring gene MPRA-validated peak3003 silencer Neighboring gene galanin receptor 2 Neighboring gene zinc activated ion channel Neighboring gene exocyst complex component 7 Neighboring gene microRNA 6868

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify signal recognition particle 68kDa protein (SRP68), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify signal recognition particle 68kDa protein (SRP68), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify signal recognition particle 68kDa protein (SRP68), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify signal recognition particle 68kDa protein (SRP68), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 7S RNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables RNA binding HDA PubMed 
    enables endoplasmic reticulum signal peptide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to ribosome binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables signal recognition particle binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables signal recognition particle binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to xenobiotic stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ribosome TAS
    Traceable Author Statement
    more info
    PubMed 
    part_of signal recognition particle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of signal recognition particle, endoplasmic reticulum targeting IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of signal recognition particle, endoplasmic reticulum targeting IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    signal recognition particle subunit SRP68
    Names
    signal recognition particle 68 kDa protein
    signal recognition particle 68kD
    signal recognition particle 68kDa

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001260502.2NP_001247431.1  signal recognition particle subunit SRP68 isoform 2

      See identical proteins and their annotated locations for NP_001247431.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AK126258, AU137443, DB315535, DQ786315
      Consensus CDS
      CCDS58601.1
      UniProtKB/TrEMBL
      B4DVI7
      Related
      ENSP00000446136.1, ENST00000539137.5
      Conserved Domains (1) summary
      pfam16969
      Location:75559
      SRP68; RNA-binding signal recognition particle 68
    2. NM_001260503.2NP_001247432.1  signal recognition particle subunit SRP68 isoform 3

      See identical proteins and their annotated locations for NP_001247432.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks a large portion of the 5' coding region, uses an alternate 5'-most exon and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AK097962, DB315535, DQ786315
      Consensus CDS
      CCDS58600.1
      UniProtKB/TrEMBL
      Q96K97
      Related
      ENSP00000473613.1, ENST00000602720.5
      Conserved Domains (1) summary
      cl22422
      Location:1258
      SRP68-RBD; RNA-binding domain of signal recognition particle subunit 68
    3. NM_014230.4NP_055045.2  signal recognition particle subunit SRP68 isoform 1

      See identical proteins and their annotated locations for NP_055045.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AF195951, AK074698, AU137443, DB315535, DQ786315
      Consensus CDS
      CCDS11738.1
      UniProtKB/Swiss-Prot
      B3KUU5, B3KWY7, G3V1U4, Q8NCJ4, Q8WUK2, Q9UHB9
      UniProtKB/TrEMBL
      B4DVI7
      Related
      ENSP00000312066.1, ENST00000307877.7
      Conserved Domains (1) summary
      pfam16969
      Location:75598
      SRP68; RNA-binding signal recognition particle 68

    RNA

    1. NR_048541.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site and lacks an internal exon in the 5' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK301100, AU137443, BC000760, DB315535, DQ786315

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      76038785..76072517 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      76931916..76965649 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)