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Srp68 signal recognition particle 68 [ Mus musculus (house mouse) ]

Gene ID: 217337, updated on 12-May-2024

Summary

Official Symbol
Srp68provided by MGI
Official Full Name
signal recognition particle 68provided by MGI
Primary source
MGI:MGI:1917447
See related
Ensembl:ENSMUSG00000020780 AllianceGenome:MGI:1917447
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610024I03Rik
Summary
Predicted to enable 7S RNA binding activity; protein domain specific binding activity; and signal recognition particle binding activity. Predicted to contribute to ribosome binding activity. Predicted to be involved in response to xenobiotic stimulus. Predicted to be located in cytosol; focal adhesion; and nucleolus. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. Orthologous to human SRP68 (signal recognition particle 68). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 39.4), limb E14.5 (RPKM 36.1) and 28 other tissues See more
Orthologs
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Genomic context

See Srp68 in Genome Data Viewer
Location:
11 E2; 11 81.06 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (116135992..116165043, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (116245166..116274217, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene cyclin dependent kinase 3 Neighboring gene envoplakin Neighboring gene predicted gene, 33250 Neighboring gene STARR-positive B cell enhancer ABC_E9847 Neighboring gene galanin receptor 2 Neighboring gene exocyst complex component 7 Neighboring gene STARR-positive B cell enhancer ABC_E7099

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC38208

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 7S RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables endoplasmic reticulum signal peptide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to ribosome binding ISO
Inferred from Sequence Orthology
more info
 
enables signal recognition particle binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables signal recognition particle binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 
part_of signal recognition particle ISO
Inferred from Sequence Orthology
more info
 
part_of signal recognition particle, endoplasmic reticulum targeting IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of signal recognition particle, endoplasmic reticulum targeting ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
signal recognition particle subunit SRP68
Names
likely ortholog of H. sapiens signal recognition particle 68kDa (SRP68)
signal recognition particle 68 kDa protein
signal recognition particle 68kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_146032.3NP_666144.3  signal recognition particle subunit SRP68

    See identical proteins and their annotated locations for NP_666144.3

    Status: PROVISIONAL

    Source sequence(s)
    BC070422
    Consensus CDS
    CCDS25662.1
    UniProtKB/Swiss-Prot
    A2AAN1, Q6NS76, Q8BMA6
    UniProtKB/TrEMBL
    A2AAN2
    Related
    ENSMUSP00000021133.10, ENSMUST00000021133.16
    Conserved Domains (1) summary
    pfam16969
    Location:74595
    SRP68; RNA-binding signal recognition particle 68

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    116135992..116165043 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)