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SRP68 signal recognition particle 68 [ Homo sapiens (human) ]

Gene ID: 6730, updated on 1-Jun-2020

Summary

Official Symbol
SRP68provided by HGNC
Official Full Name
signal recognition particle 68provided by HGNC
Primary source
HGNC:HGNC:11302
See related
Ensembl:ENSG00000167881 MIM:604858
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a subunit of the signal recognition particle (SRP). The SRP is a ribonucleoprotein complex that transports secreted and membrane proteins to the endoplasmic reticulum for processing. The complex includes a 7S RNA and six protein subunits. The encoded protein is the 68kDa component of the SRP, and forms a heterodimer with the 72kDa subunit that is required for SRP function. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and three pseudogenes of this gene are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, May 2012]
Expression
Ubiquitous expression in thyroid (RPKM 29.4), esophagus (RPKM 22.8) and 25 other tissues See more
Orthologs

Genomic context

See SRP68 in Genome Data Viewer
Location:
17q25.1
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (76038775..76072526, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (74034856..74068607, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene TEN1-CDK3 readthrough (NMD candidate) Neighboring gene cyclin dependent kinase 3 Neighboring gene envoplakin Neighboring gene galanin receptor 2 Neighboring gene zinc activated ion channel Neighboring gene exocyst complex component 7 Neighboring gene microRNA 6868

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify signal recognition particle 68kDa protein (SRP68), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify signal recognition particle 68kDa protein (SRP68), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify signal recognition particle 68kDa protein (SRP68), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify signal recognition particle 68kDa protein (SRP68), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
7S RNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
RNA binding HDA PubMed 
endoplasmic reticulum signal peptide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to ribosome binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal recognition particle binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal recognition particle binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 
response to drug IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum TAS
Traceable Author Statement
more info
PubMed 
focal adhesion IDA
Inferred from Direct Assay
more info
 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
ribosome TAS
Traceable Author Statement
more info
PubMed 
signal recognition particle IDA
Inferred from Direct Assay
more info
PubMed 
signal recognition particle, endoplasmic reticulum targeting IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal recognition particle, endoplasmic reticulum targeting IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
signal recognition particle subunit SRP68
Names
signal recognition particle 68 kDa protein
signal recognition particle 68kD
signal recognition particle 68kDa

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001260502.1NP_001247431.1  signal recognition particle subunit SRP68 isoform 2

    See identical proteins and their annotated locations for NP_001247431.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK126258, AU137443, DB315535, DQ786315
    Consensus CDS
    CCDS58601.1
    UniProtKB/Swiss-Prot
    Q9UHB9
    Related
    ENSP00000446136.1, ENST00000539137.5
    Conserved Domains (1) summary
    pfam16969
    Location:75559
    SRP68; RNA-binding signal recognition particle 68
  2. NM_001260503.1NP_001247432.1  signal recognition particle subunit SRP68 isoform 3

    See identical proteins and their annotated locations for NP_001247432.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks a large portion of the 5' coding region, uses an alternate 5'-most exon and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK097962, DB315535, DQ786315
    Consensus CDS
    CCDS58600.1
    UniProtKB/Swiss-Prot
    Q9UHB9
    Related
    ENSP00000473613.1, ENST00000602720.5
    Conserved Domains (1) summary
    cl22422
    Location:1258
    SRP68-RBD; RNA-binding domain of signal recognition particle subunit 68
  3. NM_014230.4NP_055045.2  signal recognition particle subunit SRP68 isoform 1

    See identical proteins and their annotated locations for NP_055045.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF195951, AK074698, AU137443, DB315535, DQ786315
    Consensus CDS
    CCDS11738.1
    UniProtKB/Swiss-Prot
    Q9UHB9
    Related
    ENSP00000312066.1, ENST00000307877.7
    Conserved Domains (1) summary
    pfam16969
    Location:75597
    SRP68; RNA-binding signal recognition particle 68

RNA

  1. NR_048541.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site and lacks an internal exon in the 5' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK301100, AU137443, BC000760, DB315535, DQ786315

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    76038775..76072526 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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