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    TLR5 toll like receptor 5 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 574328, updated on 5-Mar-2024

    Summary

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    Official Symbol
    TLR5provided by VGNC
    Official Full Name
    toll like receptor 5provided by VGNC
    Primary source
    VGNC:VGNC:78376
    See related
    Ensembl:ENSMMUG00000000870
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 1 NC_041754.1 (80784492..80817882, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 1 NC_027893.1 (143107629..143140886)

    Chromosome 1 - NC_041754.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 177 member B Neighboring gene dispatched RND transporter family member 1 Neighboring gene small nucleolar RNA U13 Neighboring gene sushi domain containing 4 Neighboring gene coiled-coil domain containing 185

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Toll-like receptors: insights into their possible role in the pathogenesis of lyme neuroborreliosis. Bernardino AL, et al. Infect Immun, 2008 Oct. PMID 18694963, Free PMC Article
    2. Genetic analysis of Toll/Interleukin-1 Receptor (TIR) domain sequences from rhesus macaque Toll-like receptors (TLRs) 1-10 reveals high homology to human TLR/TIR sequences. Sanghavi SK, et al. Immunogenetics, 2004 Dec. PMID 15578265
    3. Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections. Mandl JN, et al. Nat Med, 2008 Oct. PMID 18806803
    4. Natural selection in the TLR-related genes in the course of primate evolution. Nakajima T, et al. Immunogenetics, 2008 Dec. PMID 18810425

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results indicate that microglia and astrocytes respond to B. burgdorferi through TLR1/2 and TLR5.
      Title: Toll-like receptors: insights into their possible role in the pathogenesis of lyme neuroborreliosis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in toll-like receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    toll-like receptor 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130429.1 → NP_001123901.1  toll-like receptor 5 precursor

      See identical proteins and their annotated locations for NP_001123901.1

      Status: PROVISIONAL

      Source sequence(s)
      AB445651
      UniProtKB/TrEMBL
      B3Y639, G7MEH6
      Conserved Domains (6) summary
      cd00116
      Location:305 → 567
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:48 → 71
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:290 → 313
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01582
      Location:693 → 837
      TIR; TIR domain
      pfam13855
      Location:288 → 348
      LRR_8; Leucine rich repeat
      cl15307
      Location:579 → 630
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041754.1 Reference Mmul_10 Primary Assembly

      Range
      80784492..80817882 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015114806.2 → XP_014970292.2  toll-like receptor 5 isoform X1

      UniProtKB/TrEMBL
      G7MEH6
      Related
      ENSMMUP00000001163.3, ENSMMUT00000001241.4
      Conserved Domains (6) summary
      TIGR00864
      Location:554 → 634
      PCC; polycystin cation channel protein
      PLN00113
      Location:90 → 580
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00031
      Location:48 → 71
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:290 → 313
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01582
      Location:693 → 837
      TIR; TIR domain
      pfam13855
      Location:289 → 348
      LRR_8; Leucine rich repeat

    2. XM_028851519.1 → XP_028707352.1  toll-like receptor 5 isoform X1

      UniProtKB/TrEMBL
      G7MEH6
      Conserved Domains (6) summary
      TIGR00864
      Location:554 → 634
      PCC; polycystin cation channel protein
      PLN00113
      Location:90 → 580
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00031
      Location:48 → 71
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:290 → 313
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01582
      Location:693 → 837
      TIR; TIR domain
      pfam13855
      Location:289 → 348
      LRR_8; Leucine rich repeat

    RNA

    1. XR_001439542.2 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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