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TLR5 toll like receptor 5 [ Homo sapiens (human) ]

Gene ID: 7100, updated on 5-Jul-2020

Summary

Official Symbol
TLR5provided by HGNC
Official Full Name
toll like receptor 5provided by HGNC
Primary source
HGNC:HGNC:11851
See related
Ensembl:ENSG00000187554 MIM:603031
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLE1; TIL3; SLEB1; MELIOS
Summary
This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009]
Expression
Ubiquitous expression in ovary (RPKM 7.6), lung (RPKM 2.6) and 22 other tissues See more
Orthologs

Genomic context

See TLR5 in Genome Data Viewer
Location:
1q41
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (223108401..223143281, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (223282748..223316624, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724046 Neighboring gene uncharacterized LOC107985323 Neighboring gene sushi domain containing 4 Neighboring gene uncharacterized LOC105373025 Neighboring gene RNA, U4 small nuclear 57, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of toll-like receptor 5 (TLR5) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10052, MGC126430, MGC126431

Gene Ontology Provided by GOA

Function Evidence Code Pubs
interleukin-1 receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
MyD88-dependent toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
defense response to bacterium IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-8 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of toll-like receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cytokine secretion IEA
Inferred from Electronic Annotation
more info
 
toll-like receptor 5 signaling pathway TAS
Traceable Author Statement
more info
 
toll-like receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
toll-like receptor 5
Names
systemic lupus erythematosus susceptibility 1
toll/interleukin-1 receptor-like protein 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016244.1 RefSeqGene

    Range
    5035..38879
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003268.6NP_003259.2  toll-like receptor 5 precursor

    See identical proteins and their annotated locations for NP_003259.2

    Status: REVIEWED

    Source sequence(s)
    AB060695, AB445645, AL929091, BQ025528, DB448079
    Consensus CDS
    CCDS31033.1
    UniProtKB/Swiss-Prot
    O60602
    Related
    ENSP00000496355.1, ENST00000642603.2
    Conserved Domains (6) summary
    TIGR00864
    Location:554634
    PCC; polycystin cation channel protein
    sd00031
    Location:4883
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:314337
    LRR_RI; leucine-rich repeat [structural motif]
    pfam01582
    Location:693837
    TIR; TIR domain
    pfam13855
    Location:288348
    LRR_8; Leucine rich repeat
    cl26793
    Location:90581
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    223108401..223143281 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006711505.3XP_006711568.1  toll-like receptor 5 isoform X1

    See identical proteins and their annotated locations for XP_006711568.1

    UniProtKB/Swiss-Prot
    O60602
    Conserved Domains (6) summary
    TIGR00864
    Location:554634
    PCC; polycystin cation channel protein
    sd00031
    Location:4883
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:314337
    LRR_RI; leucine-rich repeat [structural motif]
    pfam01582
    Location:693837
    TIR; TIR domain
    pfam13855
    Location:288348
    LRR_8; Leucine rich repeat
    cl26793
    Location:90581
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
  2. XM_006711504.3XP_006711567.1  toll-like receptor 5 isoform X1

    See identical proteins and their annotated locations for XP_006711567.1

    UniProtKB/Swiss-Prot
    O60602
    Conserved Domains (6) summary
    TIGR00864
    Location:554634
    PCC; polycystin cation channel protein
    sd00031
    Location:4883
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:314337
    LRR_RI; leucine-rich repeat [structural motif]
    pfam01582
    Location:693837
    TIR; TIR domain
    pfam13855
    Location:288348
    LRR_8; Leucine rich repeat
    cl26793
    Location:90581
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
  3. XM_017002208.1XP_016857697.1  toll-like receptor 5 isoform X1

    UniProtKB/Swiss-Prot
    O60602
    Related
    ENSP00000493892.1, ENST00000645434.1
    Conserved Domains (6) summary
    TIGR00864
    Location:554634
    PCC; polycystin cation channel protein
    sd00031
    Location:4883
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:314337
    LRR_RI; leucine-rich repeat [structural motif]
    pfam01582
    Location:693837
    TIR; TIR domain
    pfam13855
    Location:288348
    LRR_8; Leucine rich repeat
    cl26793
    Location:90581
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
  4. XM_011509937.2XP_011508239.1  toll-like receptor 5 isoform X1

    See identical proteins and their annotated locations for XP_011508239.1

    UniProtKB/Swiss-Prot
    O60602
    Conserved Domains (6) summary
    TIGR00864
    Location:554634
    PCC; polycystin cation channel protein
    sd00031
    Location:4883
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:314337
    LRR_RI; leucine-rich repeat [structural motif]
    pfam01582
    Location:693837
    TIR; TIR domain
    pfam13855
    Location:288348
    LRR_8; Leucine rich repeat
    cl26793
    Location:90581
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
  5. XM_006711506.3XP_006711569.1  toll-like receptor 5 isoform X1

    See identical proteins and their annotated locations for XP_006711569.1

    UniProtKB/Swiss-Prot
    O60602
    Conserved Domains (6) summary
    TIGR00864
    Location:554634
    PCC; polycystin cation channel protein
    sd00031
    Location:4883
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:314337
    LRR_RI; leucine-rich repeat [structural motif]
    pfam01582
    Location:693837
    TIR; TIR domain
    pfam13855
    Location:288348
    LRR_8; Leucine rich repeat
    cl26793
    Location:90581
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
  6. XM_005273242.4XP_005273299.2  toll-like receptor 5 isoform X1

    See identical proteins and their annotated locations for XP_005273299.2

    UniProtKB/Swiss-Prot
    O60602
    Conserved Domains (6) summary
    TIGR00864
    Location:554634
    PCC; polycystin cation channel protein
    sd00031
    Location:4883
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:314337
    LRR_RI; leucine-rich repeat [structural motif]
    pfam01582
    Location:693837
    TIR; TIR domain
    pfam13855
    Location:288348
    LRR_8; Leucine rich repeat
    cl26793
    Location:90581
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
  7. XM_005273243.4XP_005273300.2  toll-like receptor 5 isoform X1

    See identical proteins and their annotated locations for XP_005273300.2

    UniProtKB/Swiss-Prot
    O60602
    Conserved Domains (6) summary
    TIGR00864
    Location:554634
    PCC; polycystin cation channel protein
    sd00031
    Location:4883
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:314337
    LRR_RI; leucine-rich repeat [structural motif]
    pfam01582
    Location:693837
    TIR; TIR domain
    pfam13855
    Location:288348
    LRR_8; Leucine rich repeat
    cl26793
    Location:90581
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
  8. XM_005273241.4XP_005273298.2  toll-like receptor 5 isoform X1

    See identical proteins and their annotated locations for XP_005273298.2

    UniProtKB/Swiss-Prot
    O60602
    Conserved Domains (6) summary
    TIGR00864
    Location:554634
    PCC; polycystin cation channel protein
    sd00031
    Location:4883
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:314337
    LRR_RI; leucine-rich repeat [structural motif]
    pfam01582
    Location:693837
    TIR; TIR domain
    pfam13855
    Location:288348
    LRR_8; Leucine rich repeat
    cl26793
    Location:90581
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
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