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TLR5 toll like receptor 5 [ Homo sapiens (human) ]

Gene ID: 7100, updated on 29-Mar-2023

Summary

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Official Symbol
TLR5provided by HGNC
Official Full Name
toll like receptor 5provided by HGNC
Primary source
HGNC:HGNC:11851
See related
Ensembl:ENSG00000187554 MIM:603031; AllianceGenome:HGNC:11851
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLE1; TIL3; SLEB1; MELIOS
Summary
This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009]
Expression
Ubiquitous expression in ovary (RPKM 7.6), lung (RPKM 2.6) and 22 other tissues See more
Orthologs
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Genomic context

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See TLR5 in Genome Data Viewer
Location:
1q41
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (223109404..223143248, complement)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (222347318..222381267, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (223282746..223316590, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724046 Neighboring gene uncharacterized LOC107985323 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:223289865-223290366 Neighboring gene uncharacterized LOC124904522 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:223416162-223416662 Neighboring gene sushi domain containing 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Endogenous Reverse Transcriptase Inhibition Attenuates TLR5-Mediated Inflammation. Dopkins N, et al. mBio, 2023 Feb 28. PMID 36645307, Free PMC Article
  2. Silent recognition of flagellins from human gut commensal bacteria by Toll-like receptor 5. Clasen SJ, et al. Sci Immunol, 2023 Jan 6. PMID 36608151
  3. Role of Toll-Like Receptor 5 in the Development of Ulcerative Colitis. Falah Alshimerry A, et al. Arch Razi Inst, 2021 Dec. PMID 35546982, Free PMC Article
  4. High Tissue TLR5 Expression Predicts Better Outcomes in Colorectal Cancer Patients. Beilmann-Lehtonen I, et al. Oncology, 2021. PMID 34139707
  5. A genetic variant in toll-like receptor 5 is linked to chemokine levels and hepatocellular carcinoma in steatohepatitis. Nischalke HD, et al. Liver Int, 2021 Sep. PMID 34051061

See all (247) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Endogenous Reverse Transcriptase Inhibition Attenuates TLR5-Mediated Inflammation.
    Title: Endogenous Reverse Transcriptase Inhibition Attenuates TLR5-Mediated Inflammation.
  2. Silent recognition of flagellins from human gut commensal bacteria by Toll-like receptor 5.
    Title: Silent recognition of flagellins from human gut commensal bacteria by Toll-like receptor 5.
  3. Upregulation of Toll-Like Receptors 2, 5, 7, and 9 in the Cervical Epithelial Cells of Iranian Women Infected with High-Risk Human Papilloma Virus.
    Title: Upregulation of Toll-Like Receptors 2, 5, 7, and 9 in the Cervical Epithelial Cells of Iranian Women Infected with High-Risk Human Papilloma Virus.
  4. Association of polymorphous light eruption with NOD-2 and TLR-5 gene polymorphisms.
    Title: Association of polymorphous light eruption with NOD-2 and TLR-5 gene polymorphisms.
  5. Predictive value of p53, Ki67 and TLR5 in neoplastic progression of Barrett's esophagus: a matched case-control study.
    Title: Predictive value of p53, Ki67 and TLR5 in neoplastic progression of Barrett's esophagus: a matched case-control study.
  6. Role of Toll-Like Receptor 5 in the Development of Ulcerative Colitis.
    Title: Role of Toll-Like Receptor 5 in the Development of Ulcerative Colitis.
  7. XIAP restrains TNF-driven intestinal inflammation and dysbiosis by promoting innate immune responses of Paneth and dendritic cells.
    Title: XIAP restrains TNF-driven intestinal inflammation and dysbiosis by promoting innate immune responses of Paneth and dendritic cells.
  8. TLR5 is expressed in Type II dendritic cells in the terminal ileum. These cells are sensitive to TNFR1/TNFR2-dependent cell death which drives IBD pathology in genetically susceptible hosts.
    Title: XIAP restrains TNF-driven intestinal inflammation and dysbiosis by promoting innate immune responses of Paneth and dendritic cells.
  9. A genetic variant in toll-like receptor 5 is linked to chemokine levels and hepatocellular carcinoma in steatohepatitis.
    Title: A genetic variant in toll-like receptor 5 is linked to chemokine levels and hepatocellular carcinoma in steatohepatitis.
  10. Association of toll-like receptor 4, 5 and 10 polymorphisms with Helicobacter pylori-positive peptic ulcer disease in a center in Jordan.
    Title: Association of toll-like receptor 4, 5 and 10 polymorphisms with Helicobacter pylori-positive peptic ulcer disease in a center in Jordan.
Submit: New GeneRIF Correction See all GeneRIFs (194)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Legionnaire disease, susceptibility to
MedGen: C1837872 OMIM: 608556 GeneReviews: Not available
Compare labs
Melioidosis, susceptibility to
MedGen: C3809925 OMIM: 615557 GeneReviews: Not available
Compare labs
Systemic lupus erythematosus, susceptibility to, 1
MedGen: C1866373 OMIM: 601744 GeneReviews: Not available
Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of toll-like receptor 5 (TLR5) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ10052, MGC126430, MGC126431

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables interleukin-1 receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of interleukin-8 production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of toll-like receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in toll-like receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
toll-like receptor 5
Names
systemic lupus erythematosus susceptibility 1
toll/interleukin-1 receptor-like protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016244.1 RefSeqGene

    Range
    5035..38879
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003268.6 → NP_003259.2  toll-like receptor 5 precursor

    See identical proteins and their annotated locations for NP_003259.2

    Status: REVIEWED

    Source sequence(s)
    AB060695, AB445645, AL929091, BQ025528, DB448079
    Consensus CDS
    CCDS31033.1
    UniProtKB/Swiss-Prot
    O60602
    UniProtKB/TrEMBL
    A0A2R8Y7Z4
    Related
    ENSP00000496355.1, ENST00000642603.2
    Conserved Domains (6) summary
    TIGR00864
    Location:554 → 634
    PCC; polycystin cation channel protein
    sd00031
    Location:48 → 83
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:314 → 337
    LRR_RI; leucine-rich repeat [structural motif]
    pfam01582
    Location:693 → 837
    TIR; TIR domain
    pfam13855
    Location:288 → 348
    LRR_8; Leucine rich repeat
    cl26793
    Location:90 → 581
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    223109404..223143248 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006711506.4 → XP_006711569.1  toll-like receptor 5 isoform X1

    See identical proteins and their annotated locations for XP_006711569.1

    UniProtKB/Swiss-Prot
    O60602
    UniProtKB/TrEMBL
    A0A2R8Y7Z4
    Conserved Domains (6) summary
    TIGR00864
    Location:554 → 634
    PCC; polycystin cation channel protein
    sd00031
    Location:48 → 83
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:314 → 337
    LRR_RI; leucine-rich repeat [structural motif]
    pfam01582
    Location:693 → 837
    TIR; TIR domain
    pfam13855
    Location:288 → 348
    LRR_8; Leucine rich repeat
    cl26793
    Location:90 → 581
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

  2. XM_006711505.4 → XP_006711568.1  toll-like receptor 5 isoform X1

    See identical proteins and their annotated locations for XP_006711568.1

    UniProtKB/Swiss-Prot
    O60602
    UniProtKB/TrEMBL
    A0A2R8Y7Z4
    Conserved Domains (6) summary
    TIGR00864
    Location:554 → 634
    PCC; polycystin cation channel protein
    sd00031
    Location:48 → 83
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:314 → 337
    LRR_RI; leucine-rich repeat [structural motif]
    pfam01582
    Location:693 → 837
    TIR; TIR domain
    pfam13855
    Location:288 → 348
    LRR_8; Leucine rich repeat
    cl26793
    Location:90 → 581
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

  3. XM_006711504.4 → XP_006711567.1  toll-like receptor 5 isoform X1

    See identical proteins and their annotated locations for XP_006711567.1

    UniProtKB/Swiss-Prot
    O60602
    UniProtKB/TrEMBL
    A0A2R8Y7Z4
    Conserved Domains (6) summary
    TIGR00864
    Location:554 → 634
    PCC; polycystin cation channel protein
    sd00031
    Location:48 → 83
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:314 → 337
    LRR_RI; leucine-rich repeat [structural motif]
    pfam01582
    Location:693 → 837
    TIR; TIR domain
    pfam13855
    Location:288 → 348
    LRR_8; Leucine rich repeat
    cl26793
    Location:90 → 581
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

  4. XM_005273243.5 → XP_005273300.2  toll-like receptor 5 isoform X1

    See identical proteins and their annotated locations for XP_005273300.2

    UniProtKB/Swiss-Prot
    O60602
    UniProtKB/TrEMBL
    A0A2R8Y7Z4
    Related
    ENSP00000440643.1, ENST00000540964.5
    Conserved Domains (6) summary
    TIGR00864
    Location:554 → 634
    PCC; polycystin cation channel protein
    sd00031
    Location:48 → 83
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:314 → 337
    LRR_RI; leucine-rich repeat [structural motif]
    pfam01582
    Location:693 → 837
    TIR; TIR domain
    pfam13855
    Location:288 → 348
    LRR_8; Leucine rich repeat
    cl26793
    Location:90 → 581
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

  5. XM_005273241.5 → XP_005273298.2  toll-like receptor 5 isoform X1

    See identical proteins and their annotated locations for XP_005273298.2

    UniProtKB/Swiss-Prot
    O60602
    UniProtKB/TrEMBL
    A0A2R8Y7Z4
    Conserved Domains (6) summary
    TIGR00864
    Location:554 → 634
    PCC; polycystin cation channel protein
    sd00031
    Location:48 → 83
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:314 → 337
    LRR_RI; leucine-rich repeat [structural motif]
    pfam01582
    Location:693 → 837
    TIR; TIR domain
    pfam13855
    Location:288 → 348
    LRR_8; Leucine rich repeat
    cl26793
    Location:90 → 581
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

  6. XM_017002208.2 → XP_016857697.1  toll-like receptor 5 isoform X1

    UniProtKB/Swiss-Prot
    O60602
    UniProtKB/TrEMBL
    A0A2R8Y7Z4
    Related
    ENSP00000493892.1, ENST00000645434.1
    Conserved Domains (6) summary
    TIGR00864
    Location:554 → 634
    PCC; polycystin cation channel protein
    sd00031
    Location:48 → 83
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:314 → 337
    LRR_RI; leucine-rich repeat [structural motif]
    pfam01582
    Location:693 → 837
    TIR; TIR domain
    pfam13855
    Location:288 → 348
    LRR_8; Leucine rich repeat
    cl26793
    Location:90 → 581
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

  7. XM_011509937.3 → XP_011508239.1  toll-like receptor 5 isoform X1

    See identical proteins and their annotated locations for XP_011508239.1

    UniProtKB/Swiss-Prot
    O60602
    UniProtKB/TrEMBL
    A0A2R8Y7Z4
    Conserved Domains (6) summary
    TIGR00864
    Location:554 → 634
    PCC; polycystin cation channel protein
    sd00031
    Location:48 → 83
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:314 → 337
    LRR_RI; leucine-rich repeat [structural motif]
    pfam01582
    Location:693 → 837
    TIR; TIR domain
    pfam13855
    Location:288 → 348
    LRR_8; Leucine rich repeat
    cl26793
    Location:90 → 581
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

  8. XM_005273242.5 → XP_005273299.2  toll-like receptor 5 isoform X1

    See identical proteins and their annotated locations for XP_005273299.2

    UniProtKB/Swiss-Prot
    O60602
    UniProtKB/TrEMBL
    A0A2R8Y7Z4
    Conserved Domains (6) summary
    TIGR00864
    Location:554 → 634
    PCC; polycystin cation channel protein
    sd00031
    Location:48 → 83
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:314 → 337
    LRR_RI; leucine-rich repeat [structural motif]
    pfam01582
    Location:693 → 837
    TIR; TIR domain
    pfam13855
    Location:288 → 348
    LRR_8; Leucine rich repeat
    cl26793
    Location:90 → 581
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

  9. XM_047429361.1 → XP_047285317.1  toll-like receptor 5 isoform X1

    UniProtKB/TrEMBL
    A0A2R8Y7Z4

  10. XM_047429367.1 → XP_047285323.1  toll-like receptor 5 isoform X1

    UniProtKB/TrEMBL
    A0A2R8Y7Z4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    222347318..222381267 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054338564.1 → XP_054194539.1  toll-like receptor 5 isoform X1

  2. XM_054338562.1 → XP_054194537.1  toll-like receptor 5 isoform X1

  3. XM_054338558.1 → XP_054194533.1  toll-like receptor 5 isoform X1

  4. XM_054338560.1 → XP_054194535.1  toll-like receptor 5 isoform X1

  5. XM_054338557.1 → XP_054194532.1  toll-like receptor 5 isoform X1

  6. XM_054338563.1 → XP_054194538.1  toll-like receptor 5 isoform X1

  7. XM_054338559.1 → XP_054194534.1  toll-like receptor 5 isoform X1

  8. XM_054338555.1 → XP_054194530.1  toll-like receptor 5 isoform X1

  9. XM_054338556.1 → XP_054194531.1  toll-like receptor 5 isoform X1

  10. XM_054338561.1 → XP_054194536.1  toll-like receptor 5 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O60602.4 GenPept UniProtKB/Swiss-Prot:O60602

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