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TLR5 toll like receptor 5 [ Homo sapiens (human) ]

Gene ID: 7100, updated on 16-Sep-2018

Summary

Official Symbol
TLR5provided by HGNC
Official Full Name
toll like receptor 5provided by HGNC
Primary source
HGNC:HGNC:11851
See related
Ensembl:ENSG00000187554 MIM:603031; Vega:OTTHUMG00000037937
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLE1; TIL3; SLEB1; MELIOS
Summary
This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009]
Expression
Ubiquitous expression in ovary (RPKM 7.6), lung (RPKM 2.6) and 22 other tissues See more
Orthologs

Genomic context

See TLR5 in Genome Data Viewer
Location:
1q41
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (223108401..223143282, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (223282748..223316624, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724046 Neighboring gene uncharacterized LOC107985323 Neighboring gene sushi domain containing 4 Neighboring gene uncharacterized LOC105373025 Neighboring gene RNA, U4 small nuclear 57, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of toll-like receptor 5 (TLR5) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Disease, organism-specific biosystem (from REACTOME)
    Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
  • Diseases associated with the TLR signaling cascade, organism-specific biosystem (from REACTOME)
    Diseases associated with the TLR signaling cascade, organism-specific biosystemToll like receptors (TLRs) are sensors of the innate immune system that detect danger signals derived from pathogens (pathogen-associated molecular patterns - PAMP) or damaged cells (damage-associate...
  • Diseases of Immune System, organism-specific biosystem (from REACTOME)
    Diseases of Immune System, organism-specific biosystemThe immune system is a complex network of the biological processes that provide defense mechanisms during infection or in response to an intrinsic danger signal. Compromised immune response may prese...
  • IRAK4 deficiency (TLR5), organism-specific biosystem (from REACTOME)
    IRAK4 deficiency (TLR5), organism-specific biosystemToll like receptor 5 (TLR5) specifically recognizes bacterial infection through binding of flagellin from pathogenic bacteria. Upon ligand binding, TLR5 dimers recruit MyD88 through their TIR domains...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Inflammatory bowel disease (IBD), organism-specific biosystem (from KEGG)
    Inflammatory bowel disease (IBD), organism-specific biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
  • Inflammatory bowel disease (IBD), conserved biosystem (from KEGG)
    Inflammatory bowel disease (IBD), conserved biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Legionellosis, organism-specific biosystem (from KEGG)
    Legionellosis, organism-specific biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
  • Legionellosis, conserved biosystem (from KEGG)
    Legionellosis, conserved biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
  • MyD88 cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
    MyD88 cascade initiated on plasma membrane, organism-specific biosystemMammalian myeloid differentiation factor 88 (MyD88) is Toll/interleukin (IL)-1 (TIR)-domain containing adapter protein which plays crucial role in TLR signaling. All TLRs, with only one exception of...
  • MyD88 deficiency (TLR5), organism-specific biosystem (from REACTOME)
    MyD88 deficiency (TLR5), organism-specific biosystemMyeloid differentiation primary response (MyD88) is an adaptor protein that mediates intracellular signaling pathways evoked by all Toll-like receptors (TLRs) (except for TLR3) and several interleuki...
  • Pathogenic Escherichia coli infection, organism-specific biosystem (from KEGG)
    Pathogenic Escherichia coli infection, organism-specific biosystemEnteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections [DS:H00278 H00277] is induction o...
  • Pathogenic Escherichia coli infection, conserved biosystem (from KEGG)
    Pathogenic Escherichia coli infection, conserved biosystemEnteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections [DS:H00278 H00277] is induction o...
  • Pathogenic Escherichia coli infection, organism-specific biosystem (from WikiPathways)
    Pathogenic Escherichia coli infection, organism-specific biosystemSources: [http://www.genome.jp/kegg/pathway/hsa/hsa05130.html KEGG]
  • Regulation of toll-like receptor signaling pathway, organism-specific biosystem (from WikiPathways)
    Regulation of toll-like receptor signaling pathway, organism-specific biosystem
    Regulation of toll-like receptor signaling pathway
  • Salmonella infection, organism-specific biosystem (from KEGG)
    Salmonella infection, organism-specific biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
  • Salmonella infection, conserved biosystem (from KEGG)
    Salmonella infection, conserved biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
  • Simplified Depiction of MYD88 Distinct Input-Output Pathway, organism-specific biosystem (from WikiPathways)
    Simplified Depiction of MYD88 Distinct Input-Output Pathway, organism-specific biosystemThis pathway is based on figure 7 from Li et al. Formation of MyD88 dimer catalyzes formation of IRAK1/TRAF6 complex. UEV1A and Ubc13 ubiquinate TRAF6 which allow for the activation of NFKB and AP-1 ...
  • Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystemLittle is known about TLR10 ligands. It has been established that the receptor homodimerizes upon binding and signals in an MyD88-dependent manner (Hasan U et al 2005; Nyman T et al 2008). It may als...
  • Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystemTLR5 is the receptor for flagellin, the protein that forms bacterial flagella. Unlike most other Pathogen-Associated Molecular Patterns (PAMPs), flagellin does not undergo any posttranslational modif...
  • Toll-Like Receptors Cascades, organism-specific biosystem (from REACTOME)
    Toll-Like Receptors Cascades, organism-specific biosystemIn human, ten members of the Toll-like receptor (TLR) family (TLR1-TLR10) have been identified (TLR11 has been found in mouse, but not in human). All TLRs have a similar Toll/IL-1 receptor (TIR) doma...
  • Toll-like Receptor Signaling, organism-specific biosystem (from WikiPathways)
    Toll-like Receptor Signaling, organism-specific biosystemThis pathway is based on the figure 1 of "Genetic variation in TLR or NFkappaB pathways and the risk of breast cancer: a case-control study" (see bibliography). TLR and NFkB are important in inflamma...
  • Toll-like Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Toll-like Receptor Signaling Pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
  • Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
    Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
  • Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
    Toll-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10052, MGC126430, MGC126431

Gene Ontology Provided by GOA

Function Evidence Code Pubs
interleukin-1 receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
MyD88-dependent toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
defense response to bacterium IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-8 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of toll-like receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cytokine secretion IEA
Inferred from Electronic Annotation
more info
 
toll-like receptor 5 signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
toll-like receptor 5
Names
systemic lupus erythematosus susceptibility 1
toll/interleukin-1 receptor-like protein 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016244.1 RefSeqGene

    Range
    5001..38877
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003268.5NP_003259.2  toll-like receptor 5 precursor

    See identical proteins and their annotated locations for NP_003259.2

    Status: REVIEWED

    Source sequence(s)
    AB060695, AB445645, AL929091, BQ025528, DB448079
    Consensus CDS
    CCDS31033.1
    UniProtKB/Swiss-Prot
    O60602
    Related
    ENSP00000496355.1, OTTHUMP00000036039, ENST00000642603.1, OTTHUMT00000092596
    Conserved Domains (6) summary
    TIGR00864
    Location:554634
    PCC; polycystin cation channel protein
    sd00031
    Location:4883
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:314337
    LRR_RI; leucine-rich repeat [structural motif]
    pfam01582
    Location:693837
    TIR; TIR domain
    pfam13855
    Location:288348
    LRR_8; Leucine rich repeat
    cl26793
    Location:90581
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    223108401..223143282 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006711505.3XP_006711568.1  toll-like receptor 5 isoform X1

    See identical proteins and their annotated locations for XP_006711568.1

    UniProtKB/Swiss-Prot
    O60602
    Conserved Domains (6) summary
    TIGR00864
    Location:554634
    PCC; polycystin cation channel protein
    sd00031
    Location:4883
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:314337
    LRR_RI; leucine-rich repeat [structural motif]
    pfam01582
    Location:693837
    TIR; TIR domain
    pfam13855
    Location:288348
    LRR_8; Leucine rich repeat
    cl26793
    Location:90581
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
  2. XM_006711504.3XP_006711567.1  toll-like receptor 5 isoform X1

    See identical proteins and their annotated locations for XP_006711567.1

    UniProtKB/Swiss-Prot
    O60602
    Conserved Domains (6) summary
    TIGR00864
    Location:554634
    PCC; polycystin cation channel protein
    sd00031
    Location:4883
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:314337
    LRR_RI; leucine-rich repeat [structural motif]
    pfam01582
    Location:693837
    TIR; TIR domain
    pfam13855
    Location:288348
    LRR_8; Leucine rich repeat
    cl26793
    Location:90581
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
  3. XM_017002208.1XP_016857697.1  toll-like receptor 5 isoform X1

    UniProtKB/Swiss-Prot
    O60602
    Related
    ENSP00000493892.1, ENST00000645434.1
    Conserved Domains (6) summary
    TIGR00864
    Location:554634
    PCC; polycystin cation channel protein
    sd00031
    Location:4883
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:314337
    LRR_RI; leucine-rich repeat [structural motif]
    pfam01582
    Location:693837
    TIR; TIR domain
    pfam13855
    Location:288348
    LRR_8; Leucine rich repeat
    cl26793
    Location:90581
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
  4. XM_011509937.2XP_011508239.1  toll-like receptor 5 isoform X1

    See identical proteins and their annotated locations for XP_011508239.1

    UniProtKB/Swiss-Prot
    O60602
    Conserved Domains (6) summary
    TIGR00864
    Location:554634
    PCC; polycystin cation channel protein
    sd00031
    Location:4883
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:314337
    LRR_RI; leucine-rich repeat [structural motif]
    pfam01582
    Location:693837
    TIR; TIR domain
    pfam13855
    Location:288348
    LRR_8; Leucine rich repeat
    cl26793
    Location:90581
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
  5. XM_006711506.3XP_006711569.1  toll-like receptor 5 isoform X1

    See identical proteins and their annotated locations for XP_006711569.1

    UniProtKB/Swiss-Prot
    O60602
    Conserved Domains (6) summary
    TIGR00864
    Location:554634
    PCC; polycystin cation channel protein
    sd00031
    Location:4883
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:314337
    LRR_RI; leucine-rich repeat [structural motif]
    pfam01582
    Location:693837
    TIR; TIR domain
    pfam13855
    Location:288348
    LRR_8; Leucine rich repeat
    cl26793
    Location:90581
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
  6. XM_005273242.4XP_005273299.2  toll-like receptor 5 isoform X1

    See identical proteins and their annotated locations for XP_005273299.2

    UniProtKB/Swiss-Prot
    O60602
    Conserved Domains (6) summary
    TIGR00864
    Location:554634
    PCC; polycystin cation channel protein
    sd00031
    Location:4883
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:314337
    LRR_RI; leucine-rich repeat [structural motif]
    pfam01582
    Location:693837
    TIR; TIR domain
    pfam13855
    Location:288348
    LRR_8; Leucine rich repeat
    cl26793
    Location:90581
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
  7. XM_005273243.4XP_005273300.2  toll-like receptor 5 isoform X1

    See identical proteins and their annotated locations for XP_005273300.2

    UniProtKB/Swiss-Prot
    O60602
    Conserved Domains (6) summary
    TIGR00864
    Location:554634
    PCC; polycystin cation channel protein
    sd00031
    Location:4883
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:314337
    LRR_RI; leucine-rich repeat [structural motif]
    pfam01582
    Location:693837
    TIR; TIR domain
    pfam13855
    Location:288348
    LRR_8; Leucine rich repeat
    cl26793
    Location:90581
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
  8. XM_005273241.4XP_005273298.2  toll-like receptor 5 isoform X1

    See identical proteins and their annotated locations for XP_005273298.2

    UniProtKB/Swiss-Prot
    O60602
    Conserved Domains (6) summary
    TIGR00864
    Location:554634
    PCC; polycystin cation channel protein
    sd00031
    Location:4883
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:314337
    LRR_RI; leucine-rich repeat [structural motif]
    pfam01582
    Location:693837
    TIR; TIR domain
    pfam13855
    Location:288348
    LRR_8; Leucine rich repeat
    cl26793
    Location:90581
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
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