Akt Akt kinase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Aktprovided by FlyBase
Official Full Name: Akt kinaseprovided by FlyBase
Primary source: FLYBASE:FBgn0010379
Locus tag: Dmel_CG4006
See related: AllianceGenome:FB:FBgn0010379
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: akt; AKT; Akt-1; AKT-1; Akt/PKB; AKT/PKB; akt1; Akt1; AKT1; CG4006; D-Akt; dakt; dAkt; dAKT; Dakt; DAkt; DAKT; dAKT/dPKB; dAkt/PKB; dakt1; dAkt1; dAKT1; Dakt1; DAkt1; DAKT1; DAKT1/PKB; Dkat1; Dmel\CG4006; dPKB; Dpkb; DPKB; DRAC-PK; DRAC-PK66; DRAC-PK85; l(3)04226; l(3)89Bq; p-Akt; P-Akt; P-AKT; pAkt; PBB; PKB; PKB/Akt; PKB/AKT; PKB/dAKT; RAC; RacPK
Summary: Enables protein serine/threonine kinase activity. Involved in several processes, including negative regulation of cell communication; regulation of neuron projection development; and transmembrane receptor protein tyrosine kinase signaling pathway. Acts upstream of with a positive effect on regulation of growth and regulation of hemocyte proliferation. Located in several cellular components, including cell cortex; cytosol; and neuronal cell body. Is expressed in several structures, including anterior endoderm; embryonic/larval neuromuscular junction; extended germ band embryo; gut section; and ovary. Used to study Parkinson's disease; alcohol use disorder; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); colorectal cancer (multiple); high grade glioma (multiple); pancreatic cancer (multiple); and reproductive organ cancer (multiple). Orthologous to several human genes including AKT2 (AKT serine/threonine kinase 2) and AKT3 (AKT serine/threonine kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 89B3-89B3; 3-58 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (16099228..16105670)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (11924950..11931392)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rac1 and Akt Exhibit Distinct Roles in Mediating Abeta-Induced Memory Damage and Learning Impairment.
Title: Rac1 and Akt Exhibit Distinct Roles in Mediating Aβ-Induced Memory Damage and Learning Impairment.
Critical Effects on Akt Signaling in Adult Zebrafish Brain Following Alterations in Light Exposure.
Title: Critical Effects on Akt Signaling in Adult Zebrafish Brain Following Alterations in Light Exposure.
Nutrition and PI3K/Akt signaling are required for p38-dependent regeneration.
Title: Nutrition and PI3K/Akt signaling are required for p38-dependent regeneration.
Optical control of ERK and AKT signaling promotes axon regeneration and functional recovery of PNS and CNS in Drosophila.
Title: Optical control of ERK and AKT signaling promotes axon regeneration and functional recovery of PNS and CNS in Drosophila.
Akt is involved in the aging process and Abeta toxicity, and manipulating Akt can restore both neuronal functions and improve behavioral activity during the processes of aging and Alzheimer's disease pathogenesis.
Title: Aging-induced Akt activation involves in aging-related pathologies and Aβ-induced toxicity.
The Hippo pathway integrates PI3K-Akt signals with mechanical and polarity cues to control tissue growth.
Title: The Hippo pathway integrates PI3K-Akt signals with mechanical and polarity cues to control tissue growth.
Flies lacking fat body fs(1)h exhibit short lifespan, increased expression of immune target genes, an inability to metabolize triglyceride, and low basal AKT activity, mostly resulting from systemic defects in insulin signalling.
Title: fs(1)h controls metabolic and immune function and enhances survival via AKT and FOXO in Drosophila.
Phosphorylation of Akt on the Pdk1 site, Thr342, is significantly reduced by Toll signaling, and expression of mutant Akt(T342D) rescues cell and animal growth, nutrient storage, and viability in animals with active Toll signaling.
Title: Innate Immune Signaling in Drosophila Blocks Insulin Signaling by Uncoupling PI(3,4,5)P(3) Production and Akt Activation.
Our findings demonstrate a non-autonomous activation of a ROS sensing mechanism by Ask1 and Akt1 to replace the missing tissue after damage. Collectively, these results provide the basis for understanding the molecular mechanism of communication between dying and living cells that triggers regeneration.
Title: Ask1 and Akt act synergistically to promote ROS-dependent regeneration in Drosophila.
The metabolic defects of cycG mutant animals are abrogated by a concomitant loss of Wdb, CycG presumably influences Akt1 activity at the PP2A nexus; Well rounded (Wrd), another B' subunit of PP2A in Drosophila, binds CycG similar to Wdb, and that its loss ameliorates some, but not all, of the metabolic defects of cycG mutants.
Title: A triangular connection between Cyclin G, PP2A and Akt1 in the regulation of growth and metabolism in Drosophila.

Submit: New GeneRIF Correction See all GeneRIFs (38)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to insulin stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cholesterol homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell migration, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in lipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term synaptic depression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_positive_effect multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of hippo signaling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation of neuron apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of peptide hormone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of triglyceride catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of positive regulation of TORC1 signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of border follicle cell migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of positive regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
NOT involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of lipid storage	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of multicellular organism growth	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of positive regulation of organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_positive_effect regulation of hemocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_positive_effect regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wound healing, spreading of cells	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Akt kinase

Names: Akt-PA; Akt-PB; Akt-PC; Akt-PD; Akt-PE; Akt1; CG4006-PA; CG4006-PB; CG4006-PC; CG4006-PD; CG4006-PE; RAC serine/threonine protein kinase; dAkt kinase; protein kinase B; related to PKA to PKC protein kinases; related to the A and C kinases

NP_001287353.1

EC 2.7.11.1

NP_001287354.1

EC 2.7.11.1

NP_732113.3

EC 2.7.11.1

non-AUG (ACG) translation initiation

NP_732114.1

EC 2.7.11.1

NP_732115.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

16099228..16105670

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001300425.1 → NP_001287354.1 Akt kinase, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287354.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LIA3, H1ZY63, H1ZY64

Conserved Domains (4) summary

smart00220
Location:185 → 442

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd01241
Location:24 → 133

PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain

cd05571
Location:189 → 509

STKc_PKB; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B

pfam00169
Location:26 → 130

PH; PH domain
NM_169706.2 → NP_732114.1 Akt kinase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732114.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LIA3, H1ZY63, H1ZY64

Related

FBpp0082681

Conserved Domains (4) summary

smart00220
Location:185 → 442

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd01241
Location:24 → 133

PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain

cd05571
Location:189 → 509

STKc_PKB; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B

pfam00169
Location:26 → 130

PH; PH domain
NM_169707.2 → NP_732115.1 Akt kinase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732115.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LIA3, H1ZY63, H1ZY64

Related

FBpp0082680

Conserved Domains (4) summary

smart00220
Location:185 → 442

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd01241
Location:24 → 133

PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain

cd05571
Location:189 → 509

STKc_PKB; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B

pfam00169
Location:26 → 130

PH; PH domain
NM_169705.2 → NP_732113.3 Akt kinase, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732113.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0KI65, Q24293, Q24469, Q24470, Q7JN11, Q8INB9, Q8T9A5, Q9VEY7

UniProtKB/TrEMBL

H1ZY63

Related

FBpp0082682

Conserved Domains (4) summary

smart00220
Location:266 → 523

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd01241
Location:105 → 214

PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain

cd05571
Location:270 → 590

STKc_PKB; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B

pfam00169
Location:107 → 211

PH; PH domain
NM_001300424.1 → NP_001287353.1 Akt kinase, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287353.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LIA3, H1ZY63, H1ZY64

Conserved Domains (4) summary

smart00220
Location:185 → 442

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd01241
Location:24 → 133

PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain

cd05571
Location:189 → 509

STKc_PKB; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B

pfam00169
Location:26 → 130

PH; PH domain