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    Lmo7 LIM domain only 7 [ Mus musculus (house mouse) ]

    Gene ID: 380928, updated on 5-Aug-2018

    Summary

    Official Symbol
    Lmo7provided by MGI
    Official Full Name
    LIM domain only 7provided by MGI
    Primary source
    MGI:MGI:1353586
    See related
    Ensembl:ENSMUSG00000033060 Vega:OTTMUSG00000034688
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm914; C78582; FBXO20; mKIAA0858
    Expression
    Broad expression in lung adult (RPKM 22.3), heart adult (RPKM 20.4) and 18 other tissues See more
    Orthologs

    Genomic context

    See Lmo7 in Genome Data Viewer
    Location:
    14 E2.3; 14 50.9 cM
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (101729928..101934708)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (102129145..102333910)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) Neighboring gene HCLS1 associated X-1 pseudogene Neighboring gene predicted gene 9922 Neighboring gene predicted gene 5854 Neighboring gene predicted gene, 41232

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    actinin binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell adherens junction ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    LIM domain only protein 7
    NP_963287.2
    XP_006519239.1
    XP_006519241.1
    XP_006519242.1
    XP_006519243.2
    XP_006519244.1
    XP_006519245.1
    XP_006519246.1
    XP_006519247.1
    XP_006519248.1
    XP_006519249.1
    XP_006519250.1
    XP_006519251.1
    XP_006519252.1
    XP_006519253.1
    XP_006519254.1
    XP_006519255.1
    XP_017171557.1
    XP_017171558.1
    XP_017171559.1
    XP_017171560.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347628.1NP_001334557.1  LIM domain only protein 7 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at a downstream start codon, and lacks an alternate exon in the 3' coding region, resulting in a frameshift compared to variant 1. The encoded isoform (2) has a shorter N-terminus and a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC163658, AK129231, BP762088
      Consensus CDS
      CCDS84158.1
      UniProtKB/TrEMBL
      E9PYI7, Q6ZQ32
    2. NM_201529.2NP_963287.2  LIM domain only protein 7 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK129231, BB614044, BP762088, EF071857
      Consensus CDS
      CCDS37001.1
      UniProtKB/TrEMBL
      A0T1J8, E9PYF4, Q6ZQ32
      Related
      ENSMUSP00000097910.3, OTTMUSP00000047977, ENSMUST00000100337.9, OTTMUST00000088062
      Conserved Domains (5) summary
      cd00014
      Location:17129
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00136
      Location:10471116
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
      cd08368
      Location:16301688
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam15949
      Location:588734
      DUF4757; Domain of unknown function (DUF4757)
      pfam15996
      Location:12411341
      PNISR; Arginine/serine-rich protein PNISR

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      101729928..101934708
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316068.1XP_017171557.1  LIM domain only protein 7 isoform X2

    2. XM_006519176.2XP_006519239.1  LIM domain only protein 7 isoform X1

      Conserved Domains (5) summary
      cd00014
      Location:17129
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00136
      Location:11141183
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
      cd08368
      Location:17111769
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam15949
      Location:655801
      DUF4757; Domain of unknown function (DUF4757)
      pfam15996
      Location:13221422
      PNISR; Arginine/serine-rich protein PNISR
    3. XM_006519178.2XP_006519241.1  LIM domain only protein 7 isoform X3

      Conserved Domains (4) summary
      cd00014
      Location:17129
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00136
      Location:11141183
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
      cd08368
      Location:16971755
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam15949
      Location:655801
      DUF4757; Domain of unknown function (DUF4757)
    4. XM_017316069.1XP_017171558.1  LIM domain only protein 7 isoform X5

    5. XM_006519179.2XP_006519242.1  LIM domain only protein 7 isoform X4

      Conserved Domains (5) summary
      cd00014
      Location:17129
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00136
      Location:11141183
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
      cd08368
      Location:16921750
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam15949
      Location:655801
      DUF4757; Domain of unknown function (DUF4757)
      pfam15996
      Location:13031403
      PNISR; Arginine/serine-rich protein PNISR
    6. XM_006519181.2XP_006519244.1  LIM domain only protein 7 isoform X7

      Conserved Domains (4) summary
      cd00014
      Location:17129
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00136
      Location:11141183
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
      cd08368
      Location:16781736
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam15949
      Location:655801
      DUF4757; Domain of unknown function (DUF4757)
    7. XM_006519182.2XP_006519245.1  LIM domain only protein 7 isoform X8

      Conserved Domains (5) summary
      cd00014
      Location:17129
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00136
      Location:10471116
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
      cd08368
      Location:16441702
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam15949
      Location:588734
      DUF4757; Domain of unknown function (DUF4757)
      pfam15996
      Location:12551355
      PNISR; Arginine/serine-rich protein PNISR
    8. XM_006519188.2XP_006519251.1  LIM domain only protein 7 isoform X12

      Conserved Domains (5) summary
      cd00014
      Location:17129
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00136
      Location:713782
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
      cd08368
      Location:13231381
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam15949
      Location:242400
      DUF4757; Domain of unknown function (DUF4757)
      pfam15996
      Location:9341034
      PNISR; Arginine/serine-rich protein PNISR
    9. XM_006519192.2XP_006519255.1  LIM domain only protein 7 isoform X16

      Conserved Domains (4) summary
      cd00014
      Location:17129
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00136
      Location:713782
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
      cd08368
      Location:12961354
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam15949
      Location:242400
      DUF4757; Domain of unknown function (DUF4757)
    10. XM_006519189.2XP_006519252.1  LIM domain only protein 7 isoform X13

      Conserved Domains (5) summary
      cd00014
      Location:17129
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00136
      Location:703772
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
      cd08368
      Location:13001358
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam15949
      Location:242390
      DUF4757; Domain of unknown function (DUF4757)
      pfam15996
      Location:9111011
      PNISR; Arginine/serine-rich protein PNISR
    11. XM_006519190.2XP_006519253.1  LIM domain only protein 7 isoform X14

      Related
      ENSMUSP00000124300.1, OTTMUSP00000047982, ENSMUST00000159806.1, OTTMUST00000088067
      Conserved Domains (4) summary
      cd00014
      Location:17129
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00136
      Location:703772
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
      cd08368
      Location:12861344
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam15949
      Location:242390
      DUF4757; Domain of unknown function (DUF4757)
    12. XM_017316070.1XP_017171559.1  LIM domain only protein 7 isoform X9

      Conserved Domains (3) summary
      cd00136
      Location:814883
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
      cd08368
      Location:14111469
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam15949
      Location:355501
      DUF4757; Domain of unknown function (DUF4757)
    13. XM_006519184.1XP_006519247.1  LIM domain only protein 7 isoform X6

      See identical proteins and their annotated locations for XP_006519247.1

      Conserved Domains (3) summary
      cd00136
      Location:881950
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
      cd08368
      Location:14781536
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam15949
      Location:422568
      DUF4757; Domain of unknown function (DUF4757)
    14. XM_006519191.1XP_006519254.1  LIM domain only protein 7 isoform X15

      Conserved Domains (2) summary
      cd00136
      Location:395464
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
      pfam15949
      Location:182
      DUF4757; Domain of unknown function (DUF4757)
    15. XM_006519180.3XP_006519243.2  LIM domain only protein 7 isoform X6

      See identical proteins and their annotated locations for XP_006519243.2

      Conserved Domains (3) summary
      cd00136
      Location:881950
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
      cd08368
      Location:14781536
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam15949
      Location:422568
      DUF4757; Domain of unknown function (DUF4757)
    16. XM_006519183.3XP_006519246.1  LIM domain only protein 7 isoform X6

      See identical proteins and their annotated locations for XP_006519246.1

      Conserved Domains (3) summary
      cd00136
      Location:881950
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
      cd08368
      Location:14781536
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam15949
      Location:422568
      DUF4757; Domain of unknown function (DUF4757)
    17. XM_006519186.3XP_006519249.1  LIM domain only protein 7 isoform X9

      Conserved Domains (3) summary
      cd00136
      Location:814883
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
      cd08368
      Location:14111469
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam15949
      Location:355501
      DUF4757; Domain of unknown function (DUF4757)
    18. XM_017316071.1XP_017171560.1  LIM domain only protein 7 isoform X10

      Related
      ENSMUSP00000123706.1, OTTMUSP00000047981, ENSMUST00000159597.7, OTTMUST00000088066
    19. XM_006519187.1XP_006519250.1  LIM domain only protein 7 isoform X11

      Related
      ENSMUSP00000124349.1, OTTMUSP00000047980, ENSMUST00000159314.7, OTTMUST00000088065
      Conserved Domains (2) summary
      cd00136
      Location:814883
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
      pfam15949
      Location:355501
      DUF4757; Domain of unknown function (DUF4757)
    20. XM_006519185.3XP_006519248.1  LIM domain only protein 7 isoform X6

      See identical proteins and their annotated locations for XP_006519248.1

      Conserved Domains (3) summary
      cd00136
      Location:881950
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
      cd08368
      Location:14781536
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam15949
      Location:422568
      DUF4757; Domain of unknown function (DUF4757)
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