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LMO7 LIM domain 7 [ Homo sapiens (human) ]

Gene ID: 4008, updated on 19-Jun-2019

Summary

Official Symbol
LMO7provided by HGNC
Official Full Name
LIM domain 7provided by HGNC
Primary source
HGNC:HGNC:6646
See related
Ensembl:ENSG00000136153 MIM:604362
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LOMP; FBX20; LMO7b; FBXO20
Summary
This gene encodes a protein containing a calponin homology (CH) domain, a PDZ domain, and a LIM domain, and may be involved in protein-protein interactions. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, however, the full-length nature of some variants is not known. [provided by RefSeq, Jan 2009]
Expression
Broad expression in lung (RPKM 43.5), esophagus (RPKM 32.9) and 17 other tissues See more
Orthologs

Genomic context

See LMO7 in Genome Data Viewer
Location:
13q22.2
Exon count:
39
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (75620434..75859870)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (76194570..76434006)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene COMM domain containing 6 Neighboring gene ubiquitin C-terminal hydrolase L3 Neighboring gene LMO7 antisense RNA 1 Neighboring gene family with sequence similarity 204 member C, pseudogene Neighboring gene LMO7DN intronic transcript 1 Neighboring gene LMO7 downstream neighbor Neighboring gene long intergenic non-protein coding RNA 561

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.
NHGRI GWA Catalog
Interrogation of the platelet-derived growth factor receptor alpha locus and corneal astigmatism in Australians of Northern European ancestry: results of a genome-wide association study.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr upregulates LMO7 in HeLa cells within 12 hours of exposure PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Adherens junction, organism-specific biosystem (from KEGG)
    Adherens junction, organism-specific biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
  • Adherens junction, conserved biosystem (from KEGG)
    Adherens junction, conserved biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
  • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
    Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
  • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
    Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0858

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-protein transferase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein polyubiquitination TAS
Traceable Author Statement
more info
 
protein ubiquitination NAS
Non-traceable Author Statement
more info
PubMed 
regulation of cell adhesion IEA
Inferred from Electronic Annotation
more info
 
regulation of signaling IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
focal adhesion HDA PubMed 
nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin ligase complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
LIM domain only protein 7
Names
F-box only protein 20
F-box protein Fbx20
LIM domain only 7 protein
LMO-7
zinc-finger domain-containing protein
NP_001293009.1
NP_001317512.1
NP_001353561.1
NP_001353562.1
NP_001353563.1
NP_001353565.1
NP_005349.3
NP_056667.2
XP_011533397.2
XP_016876063.1
XP_016876070.1
XP_016876073.1
XP_016876080.1
XP_016876081.1
XP_016876082.1
XP_016876083.1
XP_016876088.1
XP_016876092.1
XP_016876093.1
XP_024305122.1
XP_024305123.1
XP_024305124.1
XP_024305125.1
XP_024305126.1
XP_024305127.1
XP_024305129.1
XP_024305130.1
XP_024305131.1
XP_024305132.1
XP_024305133.1
XP_024305134.1
XP_024305135.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001306080.2NP_001293009.1  LIM domain only protein 7 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) is alternatively spliced at the 5' end, and contains two additional internal coding exons, compared to transcript variant 1. The encoded isoform (3) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AF144237, AF330045, AL137782, DA313248, FJ711162
    Consensus CDS
    CCDS81773.1
    UniProtKB/Swiss-Prot
    Q8WWI1
    UniProtKB/TrEMBL
    F8J2B5, F8WD26
    Related
    ENSP00000366757.4, ENST00000377534.8
    Conserved Domains (6) summary
    cd00014
    Location:17129
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00136
    Location:10031070
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cd08368
    Location:15621620
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    pfam15949
    Location:588734
    DUF4757; Domain of unknown function (DUF4757)
    cd16269
    Location:12181229
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:11751231
    GBP_C; Guanylate-binding protein, C-terminal domain
  2. NM_001330583.1NP_001317512.1  LIM domain only protein 7 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream start codon and result in an isoform (4) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AA777749, AF144237, AF330045, AL137782, DA438537, FJ711162
    Consensus CDS
    CCDS81774.1
    UniProtKB/Swiss-Prot
    Q8WWI1
    UniProtKB/TrEMBL
    E9PMT2, F8J2B5
    Related
    ENSP00000317802.8, ENST00000321797.12
    Conserved Domains (5) summary
    cd00136
    Location:770837
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cd08368
    Location:13291387
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    pfam15949
    Location:355501
    DUF4757; Domain of unknown function (DUF4757)
    cd16269
    Location:985996
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:942998
    GBP_C; Guanylate-binding protein, C-terminal domain
  3. NM_001366632.2NP_001353561.1  LIM domain only protein 7 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL137121, AL137782, AL359392
    Conserved Domains (5) summary
    cd00136
    Location:770837
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cd16269
    Location:985996
    GBP_C; coiled coil [structural motif]
    pfam15949
    Location:355502
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:942998
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl26511
    Location:9431101
    Neuromodulin_N; Gap junction protein N-terminal region
  4. NM_001366633.2NP_001353562.1  LIM domain only protein 7 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL137121, AL137782, AL359392
    Conserved Domains (5) summary
    cd00136
    Location:9611028
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cd16269
    Location:11761187
    GBP_C; coiled coil [structural motif]
    pfam15949
    Location:546693
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:11331189
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl26511
    Location:11341292
    Neuromodulin_N; Gap junction protein N-terminal region
  5. NM_001366634.2NP_001353563.1  LIM domain only protein 7 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL137121, AL137782, AL359392
  6. NM_001366636.2NP_001353565.1  LIM domain only protein 7 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL137121, AL137782, AL359392
    Conserved Domains (6) summary
    cd00136
    Location:676743
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cd08368
    Location:12351293
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    cd16269
    Location:891902
    GBP_C; coiled coil [structural motif]
    pfam15949
    Location:261408
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:848904
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl26511
    Location:8491007
    Neuromodulin_N; Gap junction protein N-terminal region
  7. NM_005358.5NP_005349.3  LIM domain only protein 7 isoform 1

    See identical proteins and their annotated locations for NP_005349.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AA777749, AB020665, AF330045, AL137244, AW805522, DB064574
    Consensus CDS
    CCDS9454.1
    UniProtKB/Swiss-Prot
    Q8WWI1
    Related
    ENSP00000342112.4, ENST00000341547.8
    Conserved Domains (6) summary
    cd00014
    Location:74181
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00136
    Location:721788
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cd08368
    Location:12801338
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    pfam15949
    Location:294452
    DUF4757; Domain of unknown function (DUF4757)
    cd16269
    Location:936947
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:893949
    GBP_C; Guanylate-binding protein, C-terminal domain
  8. NM_015842.2NP_056667.2  LIM domain only protein 7 isoform 2

    See identical proteins and their annotated locations for NP_056667.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is alternatively spliced at the 5' and 3' ends, and contains two additional internal coding exons, compared to transcript variant 1. The encoded isoform (2) has distinct N- and C-termini, and is longer than isoform 1.
    Source sequence(s)
    AA777749, AB020665, AF330045, AK055465, AW805522, DB064574, DB227898
    Consensus CDS
    CCDS53876.1
    UniProtKB/Swiss-Prot
    Q8WWI1
    UniProtKB/TrEMBL
    A0A0A0MTE2
    Related
    ENSP00000433352.1, ENST00000465261.6
    Conserved Domains (5) summary
    cd00136
    Location:770837
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cd16269
    Location:985996
    GBP_C; coiled coil [structural motif]
    pfam15949
    Location:355502
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:942998
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl26511
    Location:9431101
    Neuromodulin_N; Gap junction protein N-terminal region

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    75620434..75859870
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020574.2XP_016876063.1  LIM domain only protein 7 isoform X2

  2. XM_011535095.2XP_011533397.2  LIM domain only protein 7 isoform X11

    Conserved Domains (7) summary
    cd00014
    Location:56163
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00136
    Location:703770
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cd08368
    Location:12891347
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    cd16269
    Location:945956
    GBP_C; coiled coil [structural motif]
    pfam15949
    Location:276435
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:902958
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl26511
    Location:9031061
    Neuromodulin_N; Gap junction protein N-terminal region
  3. XM_017020581.1XP_016876070.1  LIM domain only protein 7 isoform X2

  4. XM_017020584.1XP_016876073.1  LIM domain only protein 7 isoform X5

  5. XM_024449362.1XP_024305130.1  LIM domain only protein 7 isoform X13

    Conserved Domains (6) summary
    cd00136
    Location:436503
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cd08368
    Location:10361094
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    cd16269
    Location:692703
    GBP_C; coiled coil [structural motif]
    pfam15949
    Location:9168
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:649705
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl26511
    Location:650808
    Neuromodulin_N; Gap junction protein N-terminal region
  6. XM_017020591.1XP_016876080.1  LIM domain only protein 7 isoform X2

  7. XM_017020604.1XP_016876093.1  LIM domain only protein 7 isoform X13

    Conserved Domains (6) summary
    cd00136
    Location:436503
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cd08368
    Location:10361094
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    cd16269
    Location:692703
    GBP_C; coiled coil [structural motif]
    pfam15949
    Location:9168
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:649705
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl26511
    Location:650808
    Neuromodulin_N; Gap junction protein N-terminal region
  8. XM_017020603.1XP_016876092.1  LIM domain only protein 7 isoform X16

    Conserved Domains (5) summary
    cd00136
    Location:676743
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cd16269
    Location:891902
    GBP_C; coiled coil [structural motif]
    pfam15949
    Location:261408
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:848904
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl26511
    Location:8491007
    Neuromodulin_N; Gap junction protein N-terminal region
  9. XM_017020592.1XP_016876081.1  LIM domain only protein 7 isoform X2

  10. XM_017020594.1XP_016876083.1  LIM domain only protein 7 isoform X5

  11. XM_017020593.2XP_016876082.1  LIM domain only protein 7 isoform X5

  12. XM_017020599.2XP_016876088.1  LIM domain only protein 7 isoform X10

  13. XM_024449354.1XP_024305122.1  LIM domain only protein 7 isoform X1

    Conserved Domains (6) summary
    cd00136
    Location:10421109
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cd08368
    Location:16421700
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    cd16269
    Location:12981309
    GBP_C; coiled coil [structural motif]
    pfam15949
    Location:627774
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:12551311
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl26511
    Location:12561414
    Neuromodulin_N; Gap junction protein N-terminal region
  14. XM_024449361.1XP_024305129.1  LIM domain only protein 7 isoform X12

    Related
    ENSP00000431129.1, ENST00000526202.5
    Conserved Domains (6) summary
    cd00136
    Location:640707
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cd08368
    Location:12401298
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    cd16269
    Location:896907
    GBP_C; coiled coil [structural motif]
    pfam15949
    Location:213372
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:853909
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl26511
    Location:8541012
    Neuromodulin_N; Gap junction protein N-terminal region
  15. XM_024449366.1XP_024305134.1  LIM domain only protein 7 isoform X17

    Conserved Domains (6) summary
    cd00136
    Location:426493
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cd08368
    Location:10261084
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    cd16269
    Location:682693
    GBP_C; coiled coil [structural motif]
    pfam15949
    Location:9158
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:639695
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl26511
    Location:640798
    Neuromodulin_N; Gap junction protein N-terminal region
  16. XM_024449364.1XP_024305132.1  LIM domain only protein 7 isoform X16

    Related
    ENSP00000388955.1, ENST00000447038.5
    Conserved Domains (5) summary
    cd00136
    Location:676743
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cd16269
    Location:891902
    GBP_C; coiled coil [structural motif]
    pfam15949
    Location:261408
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:848904
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl26511
    Location:8491007
    Neuromodulin_N; Gap junction protein N-terminal region
  17. XM_024449365.1XP_024305133.1  LIM domain only protein 7 isoform X13

    Conserved Domains (6) summary
    cd00136
    Location:436503
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cd08368
    Location:10361094
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    cd16269
    Location:692703
    GBP_C; coiled coil [structural motif]
    pfam15949
    Location:9168
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:649705
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl26511
    Location:650808
    Neuromodulin_N; Gap junction protein N-terminal region
  18. XM_024449357.1XP_024305125.1  LIM domain only protein 7 isoform X6

    Conserved Domains (6) summary
    cd00136
    Location:676743
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cd08368
    Location:12491307
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    cd16269
    Location:905916
    GBP_C; coiled coil [structural motif]
    pfam15949
    Location:261408
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:862918
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl26511
    Location:8631021
    Neuromodulin_N; Gap junction protein N-terminal region
  19. XM_024449358.1XP_024305126.1  LIM domain only protein 7 isoform X7

    Conserved Domains (6) summary
    cd00136
    Location:676743
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cd08368
    Location:12351293
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    cd16269
    Location:891902
    GBP_C; coiled coil [structural motif]
    pfam15949
    Location:261408
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:848904
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl26511
    Location:8491007
    Neuromodulin_N; Gap junction protein N-terminal region
  20. XM_024449359.1XP_024305127.1  LIM domain only protein 7 isoform X8

    Conserved Domains (5) summary
    cd00136
    Location:676743
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cd16269
    Location:918929
    GBP_C; coiled coil [structural motif]
    pfam15949
    Location:261408
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:875931
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl26511
    Location:8761034
    Neuromodulin_N; Gap junction protein N-terminal region
  21. XM_024449355.1XP_024305123.1  LIM domain only protein 7 isoform X3

    Conserved Domains (6) summary
    cd00136
    Location:770837
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cd08368
    Location:13431401
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    cd16269
    Location:9991010
    GBP_C; coiled coil [structural motif]
    pfam15949
    Location:355502
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:9561012
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl26511
    Location:9571115
    Neuromodulin_N; Gap junction protein N-terminal region
  22. XM_024449356.1XP_024305124.1  LIM domain only protein 7 isoform X4

    Conserved Domains (6) summary
    cd00136
    Location:770837
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cd08368
    Location:13431401
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    cd16269
    Location:9991010
    GBP_C; coiled coil [structural motif]
    pfam15949
    Location:355502
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:9561012
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl26511
    Location:9571115
    Neuromodulin_N; Gap junction protein N-terminal region
  23. XM_024449367.1XP_024305135.1  LIM domain only protein 7 isoform X18

    Conserved Domains (6) summary
    cd00136
    Location:426493
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cd08368
    Location:10121070
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    cd16269
    Location:668679
    GBP_C; coiled coil [structural motif]
    pfam15949
    Location:9158
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:625681
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl26511
    Location:626784
    Neuromodulin_N; Gap junction protein N-terminal region
  24. XM_024449363.1XP_024305131.1  LIM domain only protein 7 isoform X15

    Conserved Domains (6) summary
    cd00136
    Location:426493
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cd08368
    Location:10121070
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    cd16269
    Location:668679
    GBP_C; coiled coil [structural motif]
    pfam15949
    Location:9158
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:625681
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl26511
    Location:626784
    Neuromodulin_N; Gap junction protein N-terminal region

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_015843.1: Suppressed sequence

    Description
    NM_015843.1: This RefSeq was temporarily suppressed because the CDS is 5'' partial, and currently there is not sufficient data to support this transcript variant.
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