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LMO7 LIM domain 7 [ Homo sapiens (human) ]

Gene ID: 4008, updated on 6-Sep-2022

Summary

Official Symbol
LMO7provided by HGNC
Official Full Name
LIM domain 7provided by HGNC
Primary source
HGNC:HGNC:6646
See related
Ensembl:ENSG00000136153 MIM:604362; AllianceGenome:HGNC:6646
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LOMP; FBX20; LMO7b; FBXO20
Summary
This gene encodes a protein containing a calponin homology (CH) domain, a PDZ domain, and a LIM domain, and may be involved in protein-protein interactions. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, however, the full-length nature of some variants is not known. [provided by RefSeq, Jan 2009]
Expression
Broad expression in lung (RPKM 43.5), esophagus (RPKM 32.9) and 17 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See LMO7 in Genome Data Viewer
Location:
13q22.2
Exon count:
40
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (75620434..75859870)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (74844083..75083598)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (76194570..76434006)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene COMM domain containing 6 Neighboring gene ubiquitin C-terminal hydrolase L3 Neighboring gene LMO7 antisense RNA 1 Neighboring gene family with sequence similarity 204 member C, pseudogene Neighboring gene LMO7DN intronic transcript 1 Neighboring gene LMO7 downstream neighbor Neighboring gene long intergenic non-protein coding RNA 561

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.
EBI GWAS Catalog
Interrogation of the platelet-derived growth factor receptor alpha locus and corneal astigmatism in Australians of Northern European ancestry: results of a genome-wide association study.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr upregulates LMO7 in HeLa cells within 12 hours of exposure PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0858

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin-protein transferase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein ubiquitination NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of signaling IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in focal adhesion HDA PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of ubiquitin ligase complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
LIM domain only protein 7
Names
F-box only protein 20
F-box protein Fbx20
LIM domain only 7 protein
LMO-7
zinc-finger domain-containing protein
NP_001293009.1
NP_001317512.1
NP_001353561.1
NP_001353562.1
NP_001353563.1
NP_001353565.1
NP_005349.3
NP_056667.2
XP_011533397.3
XP_024305127.1
XP_024305131.2
XP_047286263.1
XP_047286264.1
XP_047286265.1
XP_047286266.1
XP_047286267.1
XP_047286268.1
XP_047286270.1
XP_047286271.1
XP_047286272.1
XP_047286273.1
XP_047286274.1
XP_047286275.1
XP_047286276.1
XP_047286277.1
XP_047286278.1
XP_047286279.1
XP_047286280.1
XP_047286281.1
XP_047286282.1
XP_047286283.1
XP_047286284.1
XP_047286285.1
XP_047286286.1
XP_047286287.1
XP_047286289.1
XP_047286290.1
XP_047286291.1
XP_047286292.1
XP_047286293.1
XP_047286294.1
XP_047286295.1
XP_047286296.1
XP_047286297.1
XP_047286298.1
XP_047286299.1
XP_047286300.1
XP_047286301.1
XP_047286302.1
XP_047286303.1
XP_047286304.1
XP_047286305.1
XP_047286306.1
XP_047286307.1
XP_047286308.1
XP_047286309.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001306080.2NP_001293009.1  LIM domain only protein 7 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) is alternatively spliced at the 5' end, and contains two additional internal coding exons, compared to transcript variant 1. The encoded isoform (3) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AF144237, AF330045, AL137782, DA313248, FJ711162
    Consensus CDS
    CCDS81773.1
    UniProtKB/Swiss-Prot
    Q8WWI1
    UniProtKB/TrEMBL
    F8J2B5, F8WD26
    Related
    ENSP00000366757.4, ENST00000377534.8
    Conserved Domains (6) summary
    cd00014
    Location:17129
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00136
    Location:10031070
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cd08368
    Location:15621620
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    pfam15949
    Location:588734
    DUF4757; Domain of unknown function (DUF4757)
    cd16269
    Location:12181229
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:11751231
    GBP_C; Guanylate-binding protein, C-terminal domain
  2. NM_001330583.1NP_001317512.1  LIM domain only protein 7 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream start codon and result in an isoform (4) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AA777749, AF144237, AF330045, AL137782, DA438537, FJ711162
    Consensus CDS
    CCDS81774.1
    UniProtKB/Swiss-Prot
    Q8WWI1
    UniProtKB/TrEMBL
    E9PMT2, F8J2B5
    Related
    ENSP00000317802.8, ENST00000321797.12
    Conserved Domains (5) summary
    cd00136
    Location:770837
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cd08368
    Location:13291387
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    pfam15949
    Location:355501
    DUF4757; Domain of unknown function (DUF4757)
    cd16269
    Location:985996
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:942998
    GBP_C; Guanylate-binding protein, C-terminal domain
  3. NM_001366632.2NP_001353561.1  LIM domain only protein 7 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL137121, AL137782, AL359392
    UniProtKB/TrEMBL
    A0A0A0MTE2
    Related
    ENSP00000513106.1, ENST00000605961.2
    Conserved Domains (5) summary
    cd00136
    Location:770837
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cd16269
    Location:985996
    GBP_C; coiled coil [structural motif]
    pfam15949
    Location:355502
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:942998
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl26511
    Location:9431101
    Neuromodulin_N; Gap junction protein N-terminal region
  4. NM_001366633.2NP_001353562.1  LIM domain only protein 7 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL137121, AL137782, AL359392
    Conserved Domains (5) summary
    cd00136
    Location:9611028
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cd16269
    Location:11761187
    GBP_C; coiled coil [structural motif]
    pfam15949
    Location:546693
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:11331189
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl26511
    Location:11341292
    Neuromodulin_N; Gap junction protein N-terminal region
  5. NM_001366634.2NP_001353563.1  LIM domain only protein 7 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL137121, AL137782, AL359392
    Conserved Domains (6) summary
    cd00136
    Location:676743
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cd08368
    Location:12351293
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    cd16269
    Location:891902
    GBP_C; coiled coil [structural motif]
    pfam15949
    Location:261408
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:848904
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl26511
    Location:8491007
    Neuromodulin_N; Gap junction protein N-terminal region
  6. NM_001366636.2NP_001353565.1  LIM domain only protein 7 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL137121, AL137782, AL359392
    Conserved Domains (6) summary
    cd00136
    Location:676743
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cd08368
    Location:12351293
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    cd16269
    Location:891902
    GBP_C; coiled coil [structural motif]
    pfam15949
    Location:261408
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:848904
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl26511
    Location:8491007
    Neuromodulin_N; Gap junction protein N-terminal region
  7. NM_005358.5NP_005349.3  LIM domain only protein 7 isoform 1

    See identical proteins and their annotated locations for NP_005349.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AA777749, AB020665, AF330045, AL137244, AW805522, DB064574
    Consensus CDS
    CCDS9454.1
    UniProtKB/Swiss-Prot
    Q8WWI1
    Related
    ENSP00000342112.4, ENST00000341547.8
    Conserved Domains (6) summary
    cd00014
    Location:74181
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00136
    Location:721788
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cd08368
    Location:12801338
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    pfam15949
    Location:294452
    DUF4757; Domain of unknown function (DUF4757)
    cd16269
    Location:936947
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:893949
    GBP_C; Guanylate-binding protein, C-terminal domain
  8. NM_015842.2NP_056667.2  LIM domain only protein 7 isoform 2

    See identical proteins and their annotated locations for NP_056667.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is alternatively spliced at the 5' and 3' ends, and contains two additional internal coding exons, compared to transcript variant 1. The encoded isoform (2) has distinct N- and C-termini, and is longer than isoform 1.
    Source sequence(s)
    AA777749, AB020665, AF330045, AK055465, AW805522, DB064574, DB227898
    Consensus CDS
    CCDS53876.1
    UniProtKB/Swiss-Prot
    Q8WWI1
    UniProtKB/TrEMBL
    A0A0A0MTE2
    Related
    ENSP00000433352.1, ENST00000465261.6
    Conserved Domains (5) summary
    cd00136
    Location:770837
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cd16269
    Location:985996
    GBP_C; coiled coil [structural motif]
    pfam15949
    Location:355502
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:942998
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl26511
    Location:9431101
    Neuromodulin_N; Gap junction protein N-terminal region

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    75620434..75859870
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047430323.1XP_047286279.1  LIM domain only protein 7 isoform X17

  2. XM_047430329.1XP_047286285.1  LIM domain only protein 7 isoform X20

  3. XM_047430352.1XP_047286308.1  LIM domain only protein 7 isoform X44

  4. XM_047430307.1XP_047286263.1  LIM domain only protein 7 isoform X1

  5. XM_047430308.1XP_047286264.1  LIM domain only protein 7 isoform X2

  6. XM_047430310.1XP_047286266.1  LIM domain only protein 7 isoform X4

  7. XM_047430309.1XP_047286265.1  LIM domain only protein 7 isoform X3

  8. XM_047430311.1XP_047286267.1  LIM domain only protein 7 isoform X5

  9. XM_047430312.1XP_047286268.1  LIM domain only protein 7 isoform X6

  10. XM_047430316.1XP_047286272.1  LIM domain only protein 7 isoform X9

  11. XM_047430317.1XP_047286273.1  LIM domain only protein 7 isoform X10

    UniProtKB/TrEMBL
    A0A0A0MTE2
  12. XM_047430320.1XP_047286276.1  LIM domain only protein 7 isoform X13

  13. XM_024449359.2XP_024305127.1  LIM domain only protein 7 isoform X14

    Conserved Domains (4) summary
    cd00136
    Location:676743
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cd16269
    Location:918929
    GBP_C; coiled coil [structural motif]
    pfam17380
    Location:8781033
    DUF5401; Family of unknown function (DUF5401)
    cl20817
    Location:875931
    GBP_C; Guanylate-binding protein, C-terminal domain
  14. XM_047430321.1XP_047286277.1  LIM domain only protein 7 isoform X15

  15. XM_047430322.1XP_047286278.1  LIM domain only protein 7 isoform X16

  16. XM_047430324.1XP_047286280.1  LIM domain only protein 7 isoform X18

    Related
    ENSP00000388955.1, ENST00000447038.5
  17. XM_011535095.3XP_011533397.3  LIM domain only protein 7 isoform X22

  18. XM_047430333.1XP_047286289.1  LIM domain only protein 7 isoform X24

  19. XM_047430334.1XP_047286290.1  LIM domain only protein 7 isoform X25

  20. XM_047430331.1XP_047286287.1  LIM domain only protein 7 isoform X23

  21. XM_047430337.1XP_047286293.1  LIM domain only protein 7 isoform X28

  22. XM_047430338.1XP_047286294.1  LIM domain only protein 7 isoform X29

  23. XM_047430330.1XP_047286286.1  LIM domain only protein 7 isoform X21

  24. XM_047430335.1XP_047286291.1  LIM domain only protein 7 isoform X26

  25. XM_047430336.1XP_047286292.1  LIM domain only protein 7 isoform X27

  26. XM_047430340.1XP_047286296.1  LIM domain only protein 7 isoform X31

  27. XM_047430343.1XP_047286299.1  LIM domain only protein 7 isoform X34

  28. XM_047430315.1XP_047286271.1  LIM domain only protein 7 isoform X8

  29. XM_047430319.1XP_047286275.1  LIM domain only protein 7 isoform X12

  30. XM_047430341.1XP_047286297.1  LIM domain only protein 7 isoform X32

  31. XM_047430345.1XP_047286301.1  LIM domain only protein 7 isoform X37

  32. XM_047430347.1XP_047286303.1  LIM domain only protein 7 isoform X39

  33. XM_047430350.1XP_047286306.1  LIM domain only protein 7 isoform X42

  34. XM_047430344.1XP_047286300.1  LIM domain only protein 7 isoform X35

  35. XM_047430327.1XP_047286283.1  LIM domain only protein 7 isoform X17

  36. XM_047430326.1XP_047286282.1  LIM domain only protein 7 isoform X17

  37. XM_047430353.1XP_047286309.1  LIM domain only protein 7 isoform X45

  38. XM_047430314.1XP_047286270.1  LIM domain only protein 7 isoform X7

  39. XM_047430318.1XP_047286274.1  LIM domain only protein 7 isoform X11

  40. XM_047430325.1XP_047286281.1  LIM domain only protein 7 isoform X19

  41. XM_047430339.1XP_047286295.1  LIM domain only protein 7 isoform X30

  42. XM_047430342.1XP_047286298.1  LIM domain only protein 7 isoform X33

  43. XM_047430346.1XP_047286302.1  LIM domain only protein 7 isoform X38

  44. XM_047430348.1XP_047286304.1  LIM domain only protein 7 isoform X40

  45. XM_047430351.1XP_047286307.1  LIM domain only protein 7 isoform X43

  46. XM_024449363.2XP_024305131.2  LIM domain only protein 7 isoform X36

    Related
    ENSP00000431129.1, ENST00000526202.5
  47. XM_047430349.1XP_047286305.1  LIM domain only protein 7 isoform X41

  48. XM_047430328.1XP_047286284.1  LIM domain only protein 7 isoform X17

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    74844083..75083598
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_015843.1: Suppressed sequence

    Description
    NM_015843.1: This RefSeq was temporarily suppressed because the CDS is 5'' partial, and currently there is not sufficient data to support this transcript variant.