3PDZ,1FC7,1KY9,1QAV,1KWA


Conserved Protein Domain Family
PDZ

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cd00136: PDZ 
Click on image for an interactive view with Cn3D
PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. Heterodimerization through PDZ-PDZ domain interactions adds to the domain's versatility, and PDZ domain-mediated interactions may be modulated dynamically through target phosphorylation. Some PDZ domains play a role in scaffolding supramolecular complexes. PDZ domains are found in diverse signaling proteins in bacteria, archebacteria, and eurkayotes. This CD contains two distinct structural subgroups with either a N- or C-terminal beta-strand forming the peptide-binding groove base. The circular permutation placing the strand on the N-terminus appears to be found in Eumetazoa only, while the C-terminal variant is found in all three kingdoms of life, and seems to co-occur with protease domains. PDZ domains have been named after PSD95(post synaptic density protein), DlgA (Drosophila disc large tumor suppressor), and ZO1, a mammalian tight junction protein.
Statistics
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PSSM-Id: 238080
View PSSM: cd00136
Aligned: 67 rows
Threshold Bit Score: 36.5145
Threshold Setting Gi: 21232855
Created: 10-Jan-2006
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
protein binding
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:protein binding site [polypeptide binding site]
Evidence:
  • Comment:contains the GLGF loop, a carboxylate-binding motif
  • Comment:PDZ binds to either the terminal COOH group of a peptide ligand (1KWA) or an internal peptide sequence that mimics the PDZ binding motif (1QAV)
  • Structure:1KWA: CasLIN-2 PDZ and C-terminal polypeptide ligand complex
    View structure with Cn3D
  • Citation:PMID 8674113
  • Structure:1QAV: Syntrophin PDZ - Nnos complex
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #### #                                                                         
3PDZ_A       16 NSLGISVTGgvntsv---------rhggiYVKAVip----------qGAAesdgrIHKGDRVLAv-nGVSLegat--hkq 73
1KWA_A       13 EPMGITLKMnel--------------nhcIVARImh----------gGMIhrqgtLHVGDEIREi-nGISVanqt--veq 65
gi 6635892   56 PYLGFRVNAnrdtqt--------lrcttiSIREVtpqyvnaegedvdGPAqa-agLQVGDQLVRf-aGYAVtdlaafnav 125
gi 15615149 124 RPVDYTYHGv-------------------LVTQVid----------gMPAae--kLKAGDHIIAv-dDEPVle------- 164
gi 19115836 102 DPLNFNAANynmndiisrskilgrvkpfcVVDSVav----------eSPAqe-agLCIGDELVHvqnVTSLselp--tfi 168
gi 20455288 117 GKTGLRLRKvdq---------------glFVQLVqa----------nTPAsl-vgLRFGDQLLQi-dGRDCagws--shk 167
gi 20978850 212 GALGFKPFTpei---------------snQLTNVsa----------qGAGer-agLQVGDTVLQi-nGQAVeaw----qq 260
gi 27881910 124 GKVGLRLRDidn---------------gvFVQLVqa----------nSPAal-agLRFGDQVLQi-nGQNVagwn--sdk 174
gi 27882117 524 RDLGFTLKGda----------------pvQIQSLdp----------lCPAaa-ggLKEGDYLVAv-gDTDCkwmg--vsd 573
gi 29736343  54 DSLHVRPRKgwap-------------ddeSLLNVip----------dSDAhr-agLQEGDQVLAv-nDVDFqdie--hsk 106
                        90       100
                ....*....|....*....|..
Feature 1        #  ##                
3PDZ_A       74 aVETLRntg-----qvVHLLLE 90
1KWA_A       66 lQKMLRemr-----gsITFKIV 82
gi 6635892  126 vSRHVRag------aeLPVVIL 141
gi 15615149 165 aDELLEklqgrtegetVKLTVK 186
gi 19115836 169 sNNVNKtl------dvLLIRGY 184
gi 20455288 168 aHQVVKkas----gdkIVVVVR 185
gi 20978850 261 vVNAIQshp----napIAVMVE 278
gi 27881910 175 aHKALKaaa----eqrIELIVR 192
gi 27882117 574 vMKLLKdvd----eegINIRVV 591
gi 29736343 107 aAEILKta------reISMHVR 122

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