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    RASGRP3 RAS guanyl releasing protein 3 [ Homo sapiens (human) ]

    Gene ID: 25780, updated on 5-May-2024

    Summary

    Official Symbol
    RASGRP3provided by HGNC
    Official Full Name
    RAS guanyl releasing protein 3provided by HGNC
    Primary source
    HGNC:HGNC:14545
    See related
    Ensembl:ENSG00000152689 MIM:609531; AllianceGenome:HGNC:14545
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GRP3
    Summary
    The protein encoded by this gene is a guanine nucleotide exchange factor that activates the oncogenes HRAS and RAP1A. Defects in this gene have been associated with systemic lupus erythematosus and several cancers. [provided by RefSeq, Mar 2017]
    Expression
    Broad expression in lymph node (RPKM 8.7), appendix (RPKM 6.4) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    2p22.3
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (33436348..33564731)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (33482495..33610876)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (33661415..33789798)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene latent transforming growth factor beta binding protein 1 Neighboring gene RNA, 5S ribosomal pseudogene 92 Neighboring gene microRNA 4430 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15562 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15563 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11347 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15564 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15565 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15567 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15568 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15569 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11348 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11349 Neighboring gene RASGRP3 antisense RNA 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:33808516-33809335 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15570 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15571 Neighboring gene uncharacterized LOC105374455 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15572 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15573 Neighboring gene ATPase H+ transporting V0 subunit e1 pseudogene 3 Neighboring gene family with sequence similarity 98 member A

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
    EBI GWAS Catalog
    Genome-wide association study of young-onset hypertension in the Han Chinese population of Taiwan.
    EBI GWAS Catalog
    Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0846

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium ion binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables diacylglycerol binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
     
    enables kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in MAPK cascade NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in Ras protein signal transduction TAS
    Traceable Author Statement
    more info
     
    involved_in small GTPase-mediated signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of guanyl-nucleotide exchange factor complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    ras guanyl-releasing protein 3
    Names
    CalDAG-GEFIII
    RAS guanyl releasing protein 3 (calcium and DAG-regulated)
    calcium and DAG-regulated guanine nucleotide exchange factor III
    calcium- and diacylglycerol-regulated guanine nucleotide exchange factor III
    guanine nucleotide exchange factor for Rap1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_053077.1 RefSeqGene

      Range
      45302..133384
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001139488.2NP_001132960.1  ras guanyl-releasing protein 3 isoform 1

      See identical proteins and their annotated locations for NP_001132960.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1, 2, and 4-6 all encode the same isoform (1).
      Source sequence(s)
      AA351079, BC027849, BX647990, DA336406, DA439087
      Consensus CDS
      CCDS46256.1
      UniProtKB/Swiss-Prot
      D6W583, O94931, Q53SD7, Q8IV61
      UniProtKB/TrEMBL
      A8KAB8
      Related
      ENSP00000384192.3, ENST00000403687.8
      Conserved Domains (4) summary
      cd06224
      Location:11126
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      smart00147
      Location:148384
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      pfam13499
      Location:428478
      EF-hand_7; EF-hand domain pair
      cd20862
      Location:488546
      C1_RASGRP3; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 3 (RASGRP3) and similar proteins
    2. NM_001349975.2NP_001336904.1  ras guanyl-releasing protein 3 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-6 all encode the same isoform (1).
      Source sequence(s)
      AC020594
      Consensus CDS
      CCDS46256.1
      UniProtKB/Swiss-Prot
      D6W583, O94931, Q53SD7, Q8IV61
      UniProtKB/TrEMBL
      A8KAB8
      Conserved Domains (4) summary
      cd06224
      Location:11126
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      smart00147
      Location:148384
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      pfam13499
      Location:428478
      EF-hand_7; EF-hand domain pair
      cd20862
      Location:488546
      C1_RASGRP3; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 3 (RASGRP3) and similar proteins
    3. NM_001349976.2NP_001336905.1  ras guanyl-releasing protein 3 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-6 all encode the same isoform (1).
      Source sequence(s)
      AC020594
      Consensus CDS
      CCDS46256.1
      UniProtKB/Swiss-Prot
      D6W583, O94931, Q53SD7, Q8IV61
      UniProtKB/TrEMBL
      A8KAB8
      Conserved Domains (4) summary
      cd06224
      Location:11126
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      smart00147
      Location:148384
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      pfam13499
      Location:428478
      EF-hand_7; EF-hand domain pair
      cd20862
      Location:488546
      C1_RASGRP3; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 3 (RASGRP3) and similar proteins
    4. NM_001349977.2NP_001336906.1  ras guanyl-releasing protein 3 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) represents the longest transcript and differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-6 all encode the same isoform (1).
      Source sequence(s)
      AC020594
      Consensus CDS
      CCDS46256.1
      UniProtKB/Swiss-Prot
      D6W583, O94931, Q53SD7, Q8IV61
      UniProtKB/TrEMBL
      A8KAB8
      Conserved Domains (4) summary
      cd06224
      Location:11126
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      smart00147
      Location:148384
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      pfam13499
      Location:428478
      EF-hand_7; EF-hand domain pair
      cd20862
      Location:488546
      C1_RASGRP3; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 3 (RASGRP3) and similar proteins
    5. NM_001349978.2NP_001336907.1  ras guanyl-releasing protein 3 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and uses an alternate in-frame acceptor splice site at an internal coding exon compared to variant 1. This results in an isoform (2) which is 1 aa shorter than isoform 1. Variants 3 and 7-10 all encode the same isoform (2).
      Source sequence(s)
      AC020594
      Consensus CDS
      CCDS54346.1
      UniProtKB/TrEMBL
      A8KAB8
      Conserved Domains (4) summary
      cd06224
      Location:11126
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      smart00147
      Location:148384
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00029
      Location:494543
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam13499
      Location:427477
      EF-hand_7; EF-hand domain pair
    6. NM_001349979.2NP_001336908.1  ras guanyl-releasing protein 3 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and uses an alternate in-frame acceptor splice site at an internal coding exon compared to variant 1. This results in an isoform (2) which is 1 aa shorter than isoform 1. Variants 3 and 7-10 all encode the same isoform (2).
      Source sequence(s)
      AC020594
      Consensus CDS
      CCDS54346.1
      UniProtKB/TrEMBL
      A8KAB8
      Conserved Domains (4) summary
      cd06224
      Location:11126
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      smart00147
      Location:148384
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00029
      Location:494543
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam13499
      Location:427477
      EF-hand_7; EF-hand domain pair
    7. NM_001349980.2NP_001336909.1  ras guanyl-releasing protein 3 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR and uses an alternate in-frame acceptor splice site at an internal coding exon compared to variant 1. This results in an isoform (2) which is 1 aa shorter than isoform 1. Variants 3 and 7-10 all encode the same isoform (2).
      Source sequence(s)
      AC020594
      Consensus CDS
      CCDS54346.1
      UniProtKB/TrEMBL
      A8KAB8
      Conserved Domains (4) summary
      cd06224
      Location:11126
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      smart00147
      Location:148384
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00029
      Location:494543
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam13499
      Location:427477
      EF-hand_7; EF-hand domain pair
    8. NM_001349981.2NP_001336910.1  ras guanyl-releasing protein 3 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) uses an alternate in-frame acceptor splice site at an internal coding exon compared to variant 1. This results in an isoform (2) which is 1 aa shorter than isoform 1. Variants 3 and 7-10 all encode the same isoform (2).
      Source sequence(s)
      AC020594
      Consensus CDS
      CCDS54346.1
      UniProtKB/TrEMBL
      A8KAB8
      Conserved Domains (4) summary
      cd06224
      Location:11126
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      smart00147
      Location:148384
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00029
      Location:494543
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam13499
      Location:427477
      EF-hand_7; EF-hand domain pair
    9. NM_015376.3NP_056191.1  ras guanyl-releasing protein 3 isoform 2

      See identical proteins and their annotated locations for NP_056191.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame acceptor splice site at an internal coding exon compared to variant 1. This results in an isoform (2) which is 1 aa shorter than isoform 1. Variants 3 and 7-10 all encode the same isoform (2).
      Source sequence(s)
      AA351079, AB020653, BC027849, BX114300, BX647990
      Consensus CDS
      CCDS54346.1
      UniProtKB/TrEMBL
      A8KAB8
      Related
      ENSP00000383917.1, ENST00000407811.5
      Conserved Domains (4) summary
      cd06224
      Location:11126
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      smart00147
      Location:148384
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00029
      Location:494543
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam13499
      Location:427477
      EF-hand_7; EF-hand domain pair
    10. NM_170672.3NP_733772.1  ras guanyl-releasing protein 3 isoform 1

      See identical proteins and their annotated locations for NP_733772.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-6 all encode the same isoform (1).
      Source sequence(s)
      AA351079, AC020594, BC027849, BX647990, DA439087
      Consensus CDS
      CCDS46256.1
      UniProtKB/Swiss-Prot
      D6W583, O94931, Q53SD7, Q8IV61
      UniProtKB/TrEMBL
      A8KAB8
      Related
      ENSP00000385886.3, ENST00000402538.7
      Conserved Domains (4) summary
      cd06224
      Location:11126
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      smart00147
      Location:148384
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      pfam13499
      Location:428478
      EF-hand_7; EF-hand domain pair
      cd20862
      Location:488546
      C1_RASGRP3; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 3 (RASGRP3) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      33436348..33564731
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011532746.4XP_011531048.1  ras guanyl-releasing protein 3 isoform X1

      See identical proteins and their annotated locations for XP_011531048.1

      UniProtKB/Swiss-Prot
      D6W583, O94931, Q53SD7, Q8IV61
      UniProtKB/TrEMBL
      A8KAB8
      Conserved Domains (4) summary
      cd06224
      Location:11126
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      smart00147
      Location:148384
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      pfam13499
      Location:428478
      EF-hand_7; EF-hand domain pair
      cd20862
      Location:488546
      C1_RASGRP3; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 3 (RASGRP3) and similar proteins
    2. XM_011532748.4XP_011531050.2  ras guanyl-releasing protein 3 isoform X1

      UniProtKB/Swiss-Prot
      D6W583, O94931, Q53SD7, Q8IV61
      UniProtKB/TrEMBL
      A8KAB8
      Conserved Domains (4) summary
      cd06224
      Location:11126
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      smart00147
      Location:148384
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      pfam13499
      Location:428478
      EF-hand_7; EF-hand domain pair
      cd20862
      Location:488546
      C1_RASGRP3; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 3 (RASGRP3) and similar proteins
    3. XM_047443877.1XP_047299833.1  ras guanyl-releasing protein 3 isoform X1

      UniProtKB/Swiss-Prot
      D6W583, O94931, Q53SD7, Q8IV61
    4. XM_047443879.1XP_047299835.1  ras guanyl-releasing protein 3 isoform X2

    5. XM_047443878.1XP_047299834.1  ras guanyl-releasing protein 3 isoform X2

    6. XM_017003761.3XP_016859250.1  ras guanyl-releasing protein 3 isoform X1

      UniProtKB/Swiss-Prot
      D6W583, O94931, Q53SD7, Q8IV61
      UniProtKB/TrEMBL
      A8KAB8
      Conserved Domains (4) summary
      cd06224
      Location:11126
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      smart00147
      Location:148384
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      pfam13499
      Location:428478
      EF-hand_7; EF-hand domain pair
      cd20862
      Location:488546
      C1_RASGRP3; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 3 (RASGRP3) and similar proteins

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      33482495..33610876
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054341297.1XP_054197272.1  ras guanyl-releasing protein 3 isoform X1

      UniProtKB/Swiss-Prot
      D6W583, O94931, Q53SD7, Q8IV61
    2. XM_054341296.1XP_054197271.1  ras guanyl-releasing protein 3 isoform X1

      UniProtKB/Swiss-Prot
      D6W583, O94931, Q53SD7, Q8IV61
    3. XM_054341298.1XP_054197273.1  ras guanyl-releasing protein 3 isoform X1

      UniProtKB/Swiss-Prot
      D6W583, O94931, Q53SD7, Q8IV61
    4. XM_054341300.1XP_054197275.1  ras guanyl-releasing protein 3 isoform X2

    5. XM_054341299.1XP_054197274.1  ras guanyl-releasing protein 3 isoform X2

    6. XM_054341295.1XP_054197270.1  ras guanyl-releasing protein 3 isoform X1

      UniProtKB/Swiss-Prot
      D6W583, O94931, Q53SD7, Q8IV61