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    Gcn1 GCN1 activator of EIF2AK4 [ Mus musculus (house mouse) ]

    Gene ID: 231659, updated on 23-Jun-2021

    Summary

    Official Symbol
    Gcn1provided by MGI
    Official Full Name
    GCN1 activator of EIF2AK4provided by MGI
    Primary source
    MGI:MGI:2444248
    See related
    Ensembl:ENSMUSG00000041638
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GCN; GCN1L; Gcn1l1; AL022764; mKIAA0219; 4932409G22; G431004K08Rik
    Expression
    Ubiquitous expression in ovary adult (RPKM 25.3), thymus adult (RPKM 23.0) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Gcn1 in Genome Data Viewer
    Location:
    5; 5 F
    Exon count:
    58
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (115703177..115760713)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (115565117..115622654)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (116015272..116072663)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene paxillin Neighboring gene predicted gene 13840 Neighboring gene ribosomal protein, large, P0 Neighboring gene microRNA 7029 Neighboring gene RIKEN cDNA 1110006O24 gene Neighboring gene RAB35, member RAS oncogene family Neighboring gene microRNA 7030

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ribosome binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of polysome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    eIF-2-alpha kinase activator GCN1
    Names
    GCN1 eIF-2-alpha kinase activator homolog
    GCN1 general control of amino-acid synthesis 1-like 1
    GCN1-like protein 1
    general control of amino-acid synthesis 1-like protein 1
    translational activator GCN1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172719.2NP_766307.2  eIF-2-alpha kinase activator GCN1

      Status: VALIDATED

      Source sequence(s)
      AK077013, AK089324, AK147257, BY582410, CD350892, CJ104712
      Consensus CDS
      CCDS19595.1
      UniProtKB/Swiss-Prot
      E9PVA8
      UniProtKB/TrEMBL
      Q3UHQ5, Q8BIX2, Q8BTM7
      Related
      ENSMUSP00000069432.8, ENSMUST00000064454.12
      Conserved Domains (4) summary
      cd00020
      Location:14981601
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam12074
      Location:355705
      DUF3554; Domain of unknown function (DUF3554)
      pfam13646
      Location:16161721
      HEAT_2; HEAT repeats
      sd00044
      Location:14611485
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      115703177..115760713
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_001784681.3 RNA Sequence

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