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GCN1 GCN1 activator of EIF2AK4 [ Homo sapiens (human) ]

Gene ID: 10985, updated on 6-Oct-2024

Summary

Official Symbol
GCN1provided by HGNC
Official Full Name
GCN1 activator of EIF2AK4provided by HGNC
Primary source
HGNC:HGNC:4199
See related
Ensembl:ENSG00000089154 MIM:605614; AllianceGenome:HGNC:4199
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GCN1L; GCN1L1; PRIC295
Summary
Enables RNA binding activity and cadherin binding activity. Predicted to be involved in cellular response to leucine starvation and positive regulation of transcription from RNA polymerase II promoter in response to stress. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 14.2), thyroid (RPKM 12.3) and 25 other tissues See more
Orthologs
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Genomic context

See GCN1 in Genome Data Viewer
Location:
12q24.23
Exon count:
58
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (120127202..120194715, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (120114374..120181877, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (120565006..120632518, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120540395-120540996 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:120540997-120541598 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120541599-120542200 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120542201-120542802 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:120547217-120547736 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120547737-120548254 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120548255-120548774 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7124 Neighboring gene RAB35, member RAS oncogene family Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr12:120553748-120554540 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr12:120554541-120555332 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4941 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:120555445-120555623 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:120556125-120556916 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7128 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7129 Neighboring gene RAB35 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7130 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7131 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7132 Neighboring gene microRNA 4498 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:120622010-120623209 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4942 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120635999-120636498 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:120636618-120637559 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7133 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7134 Neighboring gene Sharpr-MPRA regulatory region 12439 Neighboring gene PXN antisense RNA 1 Neighboring gene ribosomal protein lateral stalk subunit P0 Neighboring gene paxillin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: RPLP0

Clone Names

  • KIAA0219

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in GCN2-mediated signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to amino acid starvation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein-RNA covalent cross-linking repair IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in rescue of stalled ribosome IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
is_active_in cytosolic ribosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane HDA PubMed 
located_in ribosome NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
stalled ribosome sensor GCN1
Names
GCN1 (general control of amino-acid synthesis 1, yeast)-like 1
GCN1 eIF-2-alpha kinase activator homolog
GCN1 general control of amino-acid synthesis 1-like 1
GCN1, eIF2 alpha kinase activator homolog
GCN1-like protein 1
eIF-2-alpha kinase activator GCN1
general control of amino-acid synthesis 1-like protein 1
hsGCN1
peroxisome proliferator activated receptor interacting complex protein
translational activator GCN1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006836.2NP_006827.1  stalled ribosome sensor GCN1

    See identical proteins and their annotated locations for NP_006827.1

    Status: VALIDATED

    Source sequence(s)
    AC004263, AC004812, BC021129, BQ929459, BU186578, D86973, U88837
    Consensus CDS
    CCDS41847.1
    UniProtKB/Swiss-Prot
    A8KAY1, O95001, O95651, Q6P2S3, Q86X65, Q8N5I5, Q8WU80, Q92616, Q99736, Q9UE60
    UniProtKB/TrEMBL
    E1NZA1
    Related
    ENSP00000300648.6, ENST00000300648.7
    Conserved Domains (4) summary
    cd00020
    Location:14981601
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam12074
    Location:357705
    DUF3554; Domain of unknown function (DUF3554)
    pfam13646
    Location:16161721
    HEAT_2; HEAT repeats
    sd00044
    Location:14611485
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    120127202..120194715 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    120114374..120181877 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)