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GCN1 GCN1 activator of EIF2AK4 [ Homo sapiens (human) ]

Gene ID: 10985, updated on 26-Nov-2021

Summary

Official Symbol
GCN1provided by HGNC
Official Full Name
GCN1 activator of EIF2AK4provided by HGNC
Primary source
HGNC:HGNC:4199
See related
Ensembl:ENSG00000089154 MIM:605614
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GCN1L; GCN1L1; PRIC295
Expression
Ubiquitous expression in testis (RPKM 14.2), thyroid (RPKM 12.3) and 25 other tissues See more
Orthologs
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Genomic context

See GCN1 in Genome Data Viewer
Location:
12q24.23
Exon count:
58
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (120127202..120194715, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (120565006..120632518, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene BICD family like cargo adaptor 1 Neighboring gene RAB35, member RAS oncogene family Neighboring gene microRNA 4498 Neighboring gene PXN antisense RNA 1 Neighboring gene ribosomal protein lateral stalk subunit P0 Neighboring gene paxillin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: RPLP0

Homology

Clone Names

  • KIAA0219

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables cadherin binding HDA PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein kinase regulator activity IEA
Inferred from Electronic Annotation
more info
 
enables ribosome binding IEA
Inferred from Electronic Annotation
more info
 
enables translation factor activity, RNA binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to amino acid starvation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to amino acid starvation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to leucine starvation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription from RNA polymerase II promoter in response to stress ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
 
involved_in translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in membrane HDA PubMed 
part_of polysome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in ribosome NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
eIF-2-alpha kinase activator GCN1
Names
GCN1 (general control of amino-acid synthesis 1, yeast)-like 1
GCN1 eIF-2-alpha kinase activator homolog
GCN1 general control of amino-acid synthesis 1-like 1
GCN1, eIF2 alpha kinase activator homolog
GCN1-like protein 1
general control of amino-acid synthesis 1-like protein 1
hsGCN1
peroxisome proliferator activated receptor interacting complex protein
translational activator GCN1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006836.2NP_006827.1  eIF-2-alpha kinase activator GCN1

    See identical proteins and their annotated locations for NP_006827.1

    Status: VALIDATED

    Source sequence(s)
    AC004263, AC004812, BC021129, BQ929459, BU186578, D86973, U88837
    Consensus CDS
    CCDS41847.1
    UniProtKB/Swiss-Prot
    Q92616
    Related
    ENSP00000300648.6, ENST00000300648.7
    Conserved Domains (4) summary
    cd00020
    Location:14981601
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam12074
    Location:357705
    DUF3554; Domain of unknown function (DUF3554)
    pfam13646
    Location:16161721
    HEAT_2; HEAT repeats
    sd00044
    Location:14611485
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    120127202..120194715 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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