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    Ddx46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 [ Mus musculus (house mouse) ]

    Gene ID: 212880, updated on 31-Jan-2019

    Summary

    Official Symbol
    Ddx46provided by MGI
    Official Full Name
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 46provided by MGI
    Primary source
    MGI:MGI:1920895
    See related
    Ensembl:ENSMUSG00000021500
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI325430; AI957095; mKIAA0801; 2200005K02Rik; 8430438J23Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 24.8), CNS E14 (RPKM 15.7) and 28 other tissues See more
    Orthologs

    Genomic context

    See Ddx46 in Genome Data Viewer
    Location:
    13; 13 B1
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (55634974..55681267)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (55736388..55782617)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene xylosylprotein beta1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I) Neighboring gene calcium modulating ligand Neighboring gene RIKEN cDNA B230219D22 gene Neighboring gene thioredoxin domain containing 15

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC31579, MGC116676

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    probable ATP-dependent RNA helicase DDX46
    Names
    DEAD box polypeptide 46
    DEAD box protein 46
    NP_001268984.1
    XP_006517265.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282055.1NP_001268984.1  probable ATP-dependent RNA helicase DDX46

      See identical proteins and their annotated locations for NP_001268984.1

      Status: VALIDATED

      Source sequence(s)
      AC126408, BC092240, CJ170754
      Consensus CDS
      CCDS70464.1
      UniProtKB/Swiss-Prot
      Q569Z5
      Related
      ENSMUSP00000133245.1, ENSMUST00000172272.7
      Conserved Domains (3) summary
      COG0513
      Location:344826
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd00268
      Location:378581
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      pfam00271
      Location:618714
      Helicase_C; Helicase conserved C-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      55634974..55681267
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517202.3XP_006517265.1  probable ATP-dependent RNA helicase DDX46 isoform X1

      Conserved Domains (3) summary
      COG0513
      Location:344826
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd00268
      Location:378581
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      pfam00271
      Location:618714
      Helicase_C; Helicase conserved C-terminal domain

    RNA

    1. XR_873437.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_145975.3: Suppressed sequence

      Description
      NM_145975.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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