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    Ddx46 DEAD box helicase 46 [ Mus musculus (house mouse) ]

    Gene ID: 212880, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ddx46provided by MGI
    Official Full Name
    DEAD box helicase 46provided by MGI
    Primary source
    MGI:MGI:1920895
    See related
    Ensembl:ENSMUSG00000021500
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI325430; AI957095; mKIAA0801; 2200005K02Rik; 8430438J23Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 24.8), CNS E14 (RPKM 15.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ddx46 in Genome Data Viewer
    Location:
    13; 13 B1
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (55782790..55829080)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (55634975..55681267)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (55736388..55782617)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene xylosylprotein beta1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I) Neighboring gene calcium modulating ligand Neighboring gene RIKEN cDNA B230219D22 gene Neighboring gene thioredoxin domain containing 15

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC31579, MGC116676

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    probable ATP-dependent RNA helicase DDX46
    Names
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 46
    DEAD box polypeptide 46
    DEAD box protein 46
    NP_001268984.1
    XP_006517265.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282055.1NP_001268984.1  probable ATP-dependent RNA helicase DDX46

      See identical proteins and their annotated locations for NP_001268984.1

      Status: VALIDATED

      Source sequence(s)
      AC126408, BC092240, CJ170754
      Consensus CDS
      CCDS70464.1
      UniProtKB/Swiss-Prot
      Q569Z5
      Related
      ENSMUSP00000133245.2, ENSMUST00000172272.8
      Conserved Domains (3) summary
      COG0513
      Location:344826
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd00268
      Location:378581
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      pfam00271
      Location:618714
      Helicase_C; Helicase conserved C-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      55782790..55829080
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517202.5XP_006517265.1  probable ATP-dependent RNA helicase DDX46 isoform X1

      Conserved Domains (2) summary
      COG0513
      Location:344826
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd17953
      Location:361582
      DEADc_DDX46; DEAD-box helicase domain of DEAD box protein 46

    RNA

    1. XR_004938009.1 RNA Sequence

    2. XR_873437.4 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_145975.3: Suppressed sequence

      Description
      NM_145975.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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