1QDE,1HV8


Conserved Protein Domain Family
DEADc

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cd00268: DEADc (this model, PSSM-Id:238167 is obsolete and has been replaced by 350669)
Click on image for an interactive view with Cn3D
DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Statistics
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PSSM-Id: 238167
View PSSM: cd00268
Aligned: 61 rows
Threshold Bit Score: 222.36
Threshold Setting Gi: 586550
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                       #####                          
1QDE_A      16 FDDMELDENLLRGVFg-yGFEEPSaIQQRAIMPIIE---GHDVLAQAQSGTGKTGTFSIAALQRIdts------vkaPQA 85
gi 465975   46 FAELGVSQPLCDACQr-lGWMKPSkIQQAALPHALQ---GKDVIGLAETGSGKTGAFAIPVLQSLldh------pqaFFC 115
gi 549597  145 FASLGVSSLLVSHLEqkmRIKKPTsIQKQAIPQIIGnagKNDFFIHAQTGSGKTLSYLLPIISTIlnmdthvdrtsgAFA 224
gi 731667  125 FSELNLVPELIQACKn-lNYSKPTpIQSKAIPPALE---GHDIIGLAQTGSGKTAAFAIPILNRLwhd------qepYYA 194
gi 731740    4 FKSLGLSKWLTESLRa-mKITQPTaIQKACIPKILE---GRDCIGGAKTGSGKTIAFAGPMLTKWsed------psgMFG 73
gi 1175401  71 FQSMGLNQTLLRAIFk-kGFKAPTpIQRKTIPLLLE---GRDVVGMARTGSGKTAAFVIPMIEHLkstl----ansnTRA 142
gi 1351656 261 FQSMNLSRPILKGLSn-lGFEVPTqIQDKTIPLALL---GKDIVGAAVTGSGKTAAFIVPILERLlyrpk---kvptTRV 333
gi 1723162   5 FHELGISQTLIETLNa-lHINKPTkIQQISIPQFLS---EKNLIVHSPTGTGKTAAFAIPIIEKLlked-----qtaKPT 75
gi 2500535 139 FPSFGLSKIVLNNIKr-kGFRQPTpIQRKTIPLILQ---SRDIVGMARTGSGKTAAFILPMVEKLkshs----gkigARA 210
gi 2500539   5 FNELGVSPALIATLKd-nNINQPTtIQQLAIPQFLQ---HQNLIVHSPTGTGKTAVFGIPVIETLlkkp----skgtTQT 76
                       90       100       110       120       130       140       150       160
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                      
1QDE_A      86 LMLAPTRELALQIQKVVMALAfh-mDIKVHACIGGTSfvEDAEGLr-DAQIVVGTPGRVFDNIQRRr----FRTDKIKMF 159
gi 465975  116 LVLTPTRELAFQIGQQFEALGsg-iGLIAAVIVGGVDmaAQAMALarRPHIIVATPGRLVDHLENTk---gFNLKALKFL 191
gi 549597  225 LVIAPTRELASQIYHVCSTLVscchYLVPCLLIGGERkkSEKARLrkGCNFIIGTPGRVLDHLQNTkvikeQLSQSLRYI 304
gi 731667  195 CILAPTRELAQQIKETFDSLGsl-mGVRSTCIVGGMNmmDQARDLmrKPHIIIATPGRLMDHLENTk---gFSLRKLKFL 270
gi 731740   74 VVLTPTRELAMQIAEQFTALGss-mNIRVSVIVGGESivQQALDLqrKPHFIIATPGRLAHHIMSSgddtvGGLMRAKYL 152
gi 1175401 143 LILSPNRELALQTVKVVKDFSkg-tDLRSVAIVGGVSleEQFSLLsgKPDIVVATPGRFLHLKVEMk----LELSSIEYV 217
gi 1351656 334 LILCPTRELAMQCHSVATKIAsf-tDIMVCLCIGGLSlkLQEQELrkRPDIVIATPGRFIDHMRNSq---gFTVENIEIM 409
gi 1723162  76 LVIAPTRELVEQIKTTFSNIAkn-kKLRIISLIGGVPawKQIKKIktNPQIIVGTMGRIMDLLERKa----IHFSDLEHL 150
gi 2500535 211 VILSPSRELAMQTFNVFKDFArg-tELRSVLLTGGDSleEQFGMMmtNPDVIIATPGRFLHLKVEMn----LDLKSVEYV 285
gi 2500539  77 LVVAPTRELAEQIKTTFINFAkh-tHLKVVSLIGGIPiwQQLKQLenQPEIVVGTMGRVMDLLERGv----IKFEHLEHL 151
                      170       180       190       200       210       220       230
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
Feature 1                                                                             
1QDE_A     160 ILDEADEMLSSGFKEQIYQIFTLLPp-------------TTQVVLLSATMPNDVLEVTTKFMR--NPVRIL 215
gi 465975  192 IMDEADRILNMDFEVELDKILKVIPr-------------ERRTYLFSATMTKKVSKLERASLR--DPARVS 247
gi 549597  305 VLDEGDKLMELGFDETISEIIKIVHdipinsekfpklphKLVHMLCSATLTDGVNRLRNVALK--DYKLIS 373
gi 731667  271 VMDEADRLLDMEFGPVLDRILKIIPt------------qERTTYLFSATMTSKIDKLQRASLT--NPVKCA 327
gi 731740  153 VLDEADILLTSTFADHLATCISALPpk-----------dKRQTLLFTATITDQVKSLQNAPVQkgKPPLFA 212
gi 1175401 218 VFDEADRLFEMGFAAQLTEILHALPt-------------SRQTLLFSATLPRTLVDFAKAGLQ--DPVLVR 273
gi 1351656 410 VMDEADRMLEDGFADELNEIIQACPk-------------SRQTMLFSATMTDKVDDLIRLSLN--RPVRVF 465
gi 1723162 151 IIDEVDLMLDRGFKKQIFNLLEQINs-------------FKQIAVYSASYNQEAINIAKQITN--NGIFIG 206
gi 2500535 286 VFDEADRLFEMGFQEQLNELLASLPt-------------TRQTLLFSATLPNSLVDFVKAGLV--NPVLVR 341
gi 2500539 152 IIDEVDLMLDRGFKRKLFDLLSRIEk-------------FEQIAVYSASYNEETIETAKQITK--NGIFLA 207

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