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    Plk1 polo like kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 18817, updated on 16-Oct-2021

    Summary

    Official Symbol
    Plk1provided by MGI
    Official Full Name
    polo like kinase 1provided by MGI
    Primary source
    MGI:MGI:97621
    See related
    Ensembl:ENSMUSG00000030867
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Plk; STPK13
    Summary
    The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and may play a role in DNA replication during S phase. This gene is expressed in all embryonic tissues, but restricted to thymus and ovaries in adult tissues. Homozygous knockout mice were embryonic lethal, suggesting that this gene is important for early embryonic development. This gene is thought to be a potential oncogene because it is overexpressed in a variety of tumors and tumor cell lines. Depletion of this protein in cancer cells has been shown to inhibit cell proliferation and suppress oncogenic transformation; hence, it is a target for cancer therapy. [provided by RefSeq, Sep 2015]
    Expression
    Broad expression in liver E14.5 (RPKM 39.9), liver E14 (RPKM 38.7) and 17 other tissues See more
    Orthologs
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    Genomic context

    See Plk1 in Genome Data Viewer
    Location:
    7 F2; 7 65.52 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (121758658..121769107)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (122159435..122169884)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (129302951..129313389)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene partner and localizer of BRCA2 Neighboring gene 60S ribosomal protein L27-like Neighboring gene dynactin 5 Neighboring gene predicted gene 15489 Neighboring gene endoplasmic reticulum (ER) to nucleus signalling 2 Neighboring gene calcineurin-like EF hand protein 2 Neighboring gene predicted gene, 51496

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables anaphase-promoting complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in centrosome cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of mitotic spindle orientation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within establishment of protein localization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within female meiosis chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within homologous chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in microtubule bundle formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic G2 DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic sister chromatid segregation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic spindle assembly checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nuclear membrane disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in polar body extrusion after meiotic divisions ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein localization to organelle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitotic metaphase/anaphase transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitotic spindle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of protein binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein localization to cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within synaptonemal complex disassembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in centriolar satellite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in condensed chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in mitotic spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of outer kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with spindle microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle midzone ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in synaptonemal complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    serine/threonine-protein kinase PLK1
    Names
    PLK-1
    serine/threonine-protein kinase 13
    NP_035251.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011121.4NP_035251.3  serine/threonine-protein kinase PLK1

      See identical proteins and their annotated locations for NP_035251.3

      Status: REVIEWED

      Source sequence(s)
      AK164027, BG065076, CJ072470
      Consensus CDS
      CCDS21812.1
      UniProtKB/Swiss-Prot
      Q07832
      UniProtKB/TrEMBL
      Q3TPZ2
      Related
      ENSMUSP00000033154.7, ENSMUST00000033154.8
      Conserved Domains (4) summary
      smart00220
      Location:53305
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13117
      Location:509590
      POLO_box_2; Second polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
      cd13118
      Location:407494
      POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
      cd14187
      Location:45309
      STKc_PLK1; Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 1

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      121758658..121769107
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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