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PLK1 polo like kinase 1 [ Homo sapiens (human) ]

Gene ID: 5347, updated on 17-Jan-2022

Summary

Official Symbol
PLK1provided by HGNC
Official Full Name
polo like kinase 1provided by HGNC
Primary source
HGNC:HGNC:9077
See related
Ensembl:ENSG00000166851 MIM:602098
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PLK; STPK13
Summary
The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of this protein in cancer cells dramatically inhibited cell proliferation and induced apoptosis; hence, it is a target for cancer therapy. [provided by RefSeq, Sep 2015]
Expression
Biased expression in testis (RPKM 20.5), lymph node (RPKM 15.8) and 13 other tissues See more
Orthologs
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Genomic context

See PLK1 in Genome Data Viewer
Location:
16p12.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (23678889..23690367)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (23690210..23701688)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene partner and localizer of BRCA2 Neighboring gene dynactin subunit 5 Neighboring gene endoplasmic reticulum to nucleus signaling 2 Neighboring gene calcineurin like EF-hand protein 2 Neighboring gene CRISPRi-validated cis-regulatory element chr16.1865

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of polo-like kinase 1 (PLK1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag The amplified luminescent proximity homogeneous assay (AlphaScreen) identifies the interaction of HIV-1 Gag with PLK1 PubMed
Tat tat HIV-1 Tat forms a quaternary complex with Tip60, Plk1, and cyclin B1 to inhibit Plk1-mediated phosphorylation of cyclin B1 at Ser133 position PubMed
tat HIV-1 Tat directly interacts with Plk1 through the kinase (residues 53-305) and the polo-box (residues 417-480) domains of Plk1 PubMed
Vpr vpr HIV-1 Vpr R80A mutant demonstrates decreased or absent TNF production from MT4C5 cells suggesting that PLK1-Vpr interaction affects TNF production from HIV-1 infected cells PubMed
vpr HIV-1 Vpr causes increased levels of CyclinB1, Plk1, and Cdk1 in a complex with the nuclear transport and spindle assembly protein, importin beta PubMed
Vpu vpu In vitro protein-protein interaction analysis identifies a Vpu-binding host protein polo-like kinase 1 (PLK1) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables anaphase-promoting complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables magnesium ion binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity EXP
Inferred from Experiment
more info
PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
involved_in centrosome cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of mitotic spindle orientation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within establishment of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in female meiosis chromosome segregation IEA
Inferred from Electronic Annotation
more info
 
involved_in homologous chromosome segregation IEA
Inferred from Electronic Annotation
more info
 
involved_in microtubule bundle formation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitotic G2 DNA damage checkpoint signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic chromosome condensation TAS
Traceable Author Statement
more info
 
involved_in mitotic cytokinesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitotic nuclear membrane disassembly TAS
Traceable Author Statement
more info
 
involved_in mitotic sister chromatid segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic spindle assembly checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic spindle organization TAS
Traceable Author Statement
more info
 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nuclear membrane disassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of peptidyl-threonine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein localization to nucleus TAS
Traceable Author Statement
more info
 
involved_in positive regulation of proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of ubiquitin protein ligase activity TAS
Traceable Author Statement
more info
 
involved_in positive regulation of ubiquitin-protein transferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein destabilization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein localization to chromatin IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein localization to nuclear envelope IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of anaphase-promoting complex-dependent catabolic process TAS
Traceable Author Statement
more info
 
involved_in regulation of cell cycle TAS
Traceable Author Statement
more info
 
involved_in regulation of cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cytokinesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mitotic cell cycle phase transition TAS
Traceable Author Statement
more info
 
involved_in regulation of mitotic metaphase/anaphase transition IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of mitotic metaphase/anaphase transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mitotic spindle assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein localization to cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sister chromatid cohesion TAS
Traceable Author Statement
more info
 
involved_in synaptonemal complex disassembly IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in centriolar satellite IEA
Inferred from Electronic Annotation
more info
 
located_in centriole IEA
Inferred from Electronic Annotation
more info
 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromatin IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in midbody IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitotic spindle pole IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of outer kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
located_in spindle IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with spindle microtubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in spindle midzone IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in spindle pole IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptonemal complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase PLK1
Names
PLK-1
cell cycle regulated protein kinase
polo (Drosophia)-like kinase
serine/threonine-protein kinase 13
NP_005021.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005030.6NP_005021.2  serine/threonine-protein kinase PLK1

    See identical proteins and their annotated locations for NP_005021.2

    Status: REVIEWED

    Source sequence(s)
    BC014846, DC300189
    Consensus CDS
    CCDS10616.1
    UniProtKB/Swiss-Prot
    P53350
    Related
    ENSP00000300093.4, ENST00000300093.9
    Conserved Domains (3) summary
    cd13117
    Location:509590
    POLO_box_2; Second polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
    cd13118
    Location:407494
    POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
    cd14187
    Location:45309
    STKc_PLK1; Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    23678889..23690367
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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