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Dctn5 dynactin 5 [ Mus musculus (house mouse) ]

Gene ID: 59288, updated on 26-Sep-2022

Summary

Official Symbol
Dctn5provided by MGI
Official Full Name
dynactin 5provided by MGI
Primary source
MGI:MGI:1891689
See related
Ensembl:ENSMUSG00000030868 AllianceGenome:MGI:1891689
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
b2b315Clo; 4930427E12Rik
Summary
Acts upstream of or within aorta development; coronary vasculature development; and ventricular septum development. Predicted to be located in centrosome; nuclear membrane; and nucleoplasm. Predicted to be part of dynactin complex. Is expressed in cervical ganglion; cervico-thoracic ganglion; dorsal root ganglion; glossopharyngeal ganglion; and trigeminal ganglion. Orthologous to human DCTN5 (dynactin subunit 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 35.2), CNS E18 (RPKM 35.1) and 28 other tissues See more
Orthologs
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Genomic context

See Dctn5 in Genome Data Viewer
Location:
7; 7 F2
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (121732264..121748267)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (122133041..122149044)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit AB1 Neighboring gene partner and localizer of BRCA2 Neighboring gene 60S ribosomal protein L27-like Neighboring gene predicted gene 15489 Neighboring gene polo like kinase 1 Neighboring gene endoplasmic reticulum (ER) to nucleus signalling 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: Plk1

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
part_of dynactin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of dynactin complex ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dynactin subunit 5
Names
dynactin 4
dynactin subunit p25
p25 dynactin subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021608.3NP_067621.3  dynactin subunit 5

    See identical proteins and their annotated locations for NP_067621.3

    Status: VALIDATED

    Source sequence(s)
    AK076738, AK151876
    Consensus CDS
    CCDS21811.1
    UniProtKB/Swiss-Prot
    Q99J17, Q9QZB9
    UniProtKB/TrEMBL
    A0A8C6N420
    Related
    ENSMUSP00000033156.5, ENSMUST00000033156.5
    Conserved Domains (1) summary
    cd03359
    Location:13173
    LbH_Dynactin_5; Dynactin 5 (or subunit p25); Dynactin is a major component of the activator complex that stimulates dynein-mediated vesicle transport. Dynactin is a heterocomplex of at least eight subunits, including a 150,000-MW protein called Glued, the actin-capping ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    121732264..121748267
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)