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Plk1 polo like kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 18817, updated on 22-Jan-2023

Summary

Official Symbol
Plk1provided by MGI
Official Full Name
polo like kinase 1provided by MGI
Primary source
MGI:MGI:97621
See related
Ensembl:ENSMUSG00000030867 AllianceGenome:MGI:97621
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Plk; STPK13
Summary
The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and may play a role in DNA replication during S phase. This gene is expressed in all embryonic tissues, but restricted to thymus and ovaries in adult tissues. Homozygous knockout mice were embryonic lethal, suggesting that this gene is important for early embryonic development. This gene is thought to be a potential oncogene because it is overexpressed in a variety of tumors and tumor cell lines. Depletion of this protein in cancer cells has been shown to inhibit cell proliferation and suppress oncogenic transformation; hence, it is a target for cancer therapy. [provided by RefSeq, Sep 2015]
Expression
Broad expression in liver E14.5 (RPKM 39.9), liver E14 (RPKM 38.7) and 17 other tissues See more
Orthologs
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Genomic context

See Plk1 in Genome Data Viewer
Location:
7 F2; 7 65.52 cM
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (121758658..121769107)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (122159435..122169884)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene partner and localizer of BRCA2 Neighboring gene 60S ribosomal protein L27-like Neighboring gene dynactin 5 Neighboring gene predicted gene 15489 Neighboring gene endoplasmic reticulum (ER) to nucleus signalling 2 Neighboring gene calcineurin-like EF hand protein 2 Neighboring gene predicted gene, 51496

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables anaphase-promoting complex binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in centrosome cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of mitotic spindle orientation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within establishment of protein localization ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within female meiosis chromosome segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within homologous chromosome segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in microtubule bundle formation ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic G2 DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic sister chromatid segregation ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic spindle assembly checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in nuclear membrane disassembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in polar body extrusion after meiotic divisions ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in protein destabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to chromatin ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein localization to organelle IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitotic metaphase/anaphase transition ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitotic spindle assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein localization to cell cortex ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within synaptonemal complex disassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in centriolar satellite IDA
Inferred from Direct Assay
more info
PubMed 
located_in centriole IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
located_in condensed chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in mitotic spindle pole IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of outer kinetochore ISO
Inferred from Sequence Orthology
more info
 
located_in spindle ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with spindle microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in spindle midzone ISO
Inferred from Sequence Orthology
more info
 
is_active_in spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in synaptonemal complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase PLK1
Names
PLK-1
serine/threonine-protein kinase 13
NP_035251.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011121.4NP_035251.3  serine/threonine-protein kinase PLK1

    See identical proteins and their annotated locations for NP_035251.3

    Status: REVIEWED

    Source sequence(s)
    AK164027, BG065076, CJ072470
    Consensus CDS
    CCDS21812.1
    UniProtKB/Swiss-Prot
    Q07832
    UniProtKB/TrEMBL
    A0A8C6IAQ2, Q3TPZ2
    Related
    ENSMUSP00000033154.7, ENSMUST00000033154.8
    Conserved Domains (4) summary
    smart00220
    Location:53305
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13117
    Location:509590
    POLO_box_2; Second polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
    cd13118
    Location:407494
    POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
    cd14187
    Location:45309
    STKc_PLK1; Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    121758658..121769107
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)