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DCTN5 dynactin subunit 5 [ Homo sapiens (human) ]

Gene ID: 84516, updated on 22-Aug-2020

Summary

Official Symbol
DCTN5provided by HGNC
Official Full Name
dynactin subunit 5provided by HGNC
Primary source
HGNC:HGNC:24594
See related
Ensembl:ENSG00000166847 MIM:612962
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a subunit of dynactin, a component of the cytoplasmic dynein motor machinery involved in minus-end-directed transport. The encoded protein is a component of the pointed-end subcomplex and is thought to bind membranous cargo. A pseudogene of this gene is located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Expression
Ubiquitous expression in brain (RPKM 13.0), testis (RPKM 7.5) and 25 other tissues See more
Orthologs

Genomic context

See DCTN5 in Genome Data Viewer
Location:
16p12.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (23641431..23677472)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (23652687..23685068)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit AB1 Neighboring gene partner and localizer of BRCA2 Neighboring gene polo like kinase 1 Neighboring gene endoplasmic reticulum to nucleus signaling 2 Neighboring gene calcineurin like EF-hand protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC3248

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ER to Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
 
antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
Traceable Author Statement
more info
 
aorta development IEA
Inferred from Electronic Annotation
more info
 
coronary vasculature development IEA
Inferred from Electronic Annotation
more info
 
ventricular septum development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
condensed chromosome kinetochore IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nuclear membrane IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
dynactin subunit 5
Names
dynactin 4
dynactin 5 (p25)
dynactin subunit p25

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199011.2NP_001185940.1  dynactin subunit 5 isoform 2

    See identical proteins and their annotated locations for NP_001185940.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks multiple coding exons and uses a distinct 3' terminal exon compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    CR745557, DA310703
    Consensus CDS
    CCDS58435.1
    UniProtKB/Swiss-Prot
    Q9BTE1
    Related
    ENSP00000455685.1, ENST00000568272.1
    Conserved Domains (1) summary
    cl00160
    Location:1339
    LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...
  2. NM_001199743.2NP_001186672.1  dynactin subunit 5 isoform 3

    See identical proteins and their annotated locations for NP_001186672.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 3, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC008870, CD388246, DA310703
    Consensus CDS
    CCDS58436.1
    UniProtKB/Swiss-Prot
    Q9BTE1
    Related
    ENSP00000454691.1, ENST00000563998.5
    Conserved Domains (1) summary
    cd03359
    Location:13151
    LbH_Dynactin_5; Dynactin 5 (or subunit p25); Dynactin is a major component of the activator complex that stimulates dynein-mediated vesicle transport. Dynactin is a heterocomplex of at least eight subunits, including a 150,000-MW protein called Glued, the actin-capping ...
  3. NM_032486.4NP_115875.1  dynactin subunit 5 isoform 1

    See identical proteins and their annotated locations for NP_115875.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC008870, BC004191, DA310703
    Consensus CDS
    CCDS10615.1
    UniProtKB/Swiss-Prot
    Q9BTE1
    Related
    ENSP00000300087.2, ENST00000300087.7
    Conserved Domains (1) summary
    cd03359
    Location:13173
    LbH_Dynactin_5; Dynactin 5 (or subunit p25); Dynactin is a major component of the activator complex that stimulates dynein-mediated vesicle transport. Dynactin is a heterocomplex of at least eight subunits, including a 150,000-MW protein called Glued, the actin-capping ...

RNA

  1. NR_037573.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) includes an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC008870, BC004191, DA310703, DB087566

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    23641431..23677472
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001752007.2 RNA Sequence

  2. XR_001752006.2 RNA Sequence

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