vav-1 Protein vav;Protein vav-1 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: vav-1
Gene description: Protein vav;Protein vav-1
Primary source: WormBase:WBGene00006887
Locus tag: CELE_C35B8.2
See related: AllianceGenome:WB:WBGene00006887
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable guanyl-nucleotide exchange factor activity and metal ion binding activity. Involved in several processes, including negative regulation of Notch signaling pathway; positive regulation of nematode male tail tip morphogenesis; and regulation of vulval development. Is expressed in several structures, including gonad; intestine; nervous system; pharynx; and tail hypodermis. Orthologous to human VAV1 (vav guanine nucleotide exchange factor 1); VAV2 (vav guanine nucleotide exchange factor 2); and VAV3 (vav guanine nucleotide exchange factor 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: X

Exon count:: 19

Sequence:: Chromosome: X; NC_003284.9 (9216866..9232137, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We show that Rho/Rac-family GTPases and the signaling molecule inositol triphosphate (IP(3)) act downstream of VAV-1 signaling and that the VAV-1 pathway modulates rhythmic behaviors by regulating the concentration of intracellular Ca(2+).(VAV-1)
Title: The Rho/Rac-family guanine nucleotide exchange factor VAV-1 regulates rhythmic behaviors in C. elegans.
VAV-1 in the ALA interneuron also serves a critical function to suppress locomotion and feeding behavior during sleep-like quiescence
Title: A Conserved GEF for Rho-Family GTPases Acts in an EGF Signaling Pathway to Promote Sleep-like Quiescence in Caenorhabditis elegans.
The data describe a novel neuromodulatory role for VAV-1-dependent signaling in the regulation of motor circuit activity and locomotion.
Title: VAV-1 acts in a single interneuron to inhibit motor circuit activity in Caenorhabditis elegans.
results suggest that lin-12, mir-61, and vav-1 form a feedback loop that helps maximize lin-12 activity in spatial patterning 2 of vulval precursor cells
Title: LIN-12/Notch activation leads to microRNA-mediated down-regulation of Vav in C. elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C35B8.2 (e-PCR)
- UniSTS:312204

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of Notch signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nematode male tail tip morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of vulval development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Protein vav;Protein vav-1

NP_001041222.1

Confirmed by transcript evidence

NP_001359918.1

Confirmed by transcript evidence

NP_001360680.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

9216866..9232137 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001373413.3 → NP_001360680.1 Protein vav [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A4V0ILE7

Conserved Domains (7) summary

cd09940
Location:821 → 921

SH2_Vav_family; Src homology 2 (SH2) domain found in the Vav family

smart00326
Location:923 → 983

SH3; Src homology 3 domains

cd00014
Location:34 → 145

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00029
Location:612 → 653

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00160
Location:237 → 431

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cl17036
Location:689 → 742

SH3; Src Homology 3 domain superfamily

cl17171
Location:449 → 598

PH-like; Pleckstrin homology-like domain
NM_001047757.3 → NP_001041222.1 Protein vav-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001041222.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q45FX5

Conserved Domains (7) summary

cd09940
Location:793 → 893

SH2_Vav_family; Src homology 2 (SH2) domain found in the Vav family

smart00326
Location:895 → 955

SH3; Src homology 3 domains

cd00014
Location:6 → 117

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00029
Location:584 → 625

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00160
Location:209 → 403

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

pfam00169
Location:447 → 561

PH; PH domain

cl17171
Location:421 → 570

PH-like; Pleckstrin homology-like domain
NM_001373412.3 → NP_001359918.1 Protein vav-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q18479, Q45FX5

Conserved Domains (7) summary

cd09940
Location:825 → 925

SH2_Vav_family; Src homology 2 (SH2) domain found in the Vav family

smart00326
Location:927 → 987

SH3; Src homology 3 domains

cd00014
Location:38 → 149

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00029
Location:616 → 657

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00160
Location:241 → 435

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd01223
Location:453 → 602

PH_Vav; Vav pleckstrin homology (PH) domain

cl17036
Location:693 → 746

SH3; Src Homology 3 domain superfamily