2L0A,3HAJ,3IQL,2D8H,2KBT,1OEB,2DLM,2EPD,2DM1,4GBQ


Conserved Protein Domain Family
SH3

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smart00326: SH3 
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Src homology 3 domains
Src homology 3 (SH3) domains bind to target proteins through sequences containing proline and hydrophobic amino acids. Pro-containing polypeptides may bind to SH3 domains in 2 different binding orientations.
Statistics
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PSSM-Id: 214620
View PSSM: smart00326
Aligned: 297 rows
Threshold Bit Score: 33.2805
Threshold Setting Gi: 4521278
Created: 13-Jul-2011
Updated: 16-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
2L0A_A         16 EARKVRAIYDFEA----AEDNELTFKAGEIITVLDDs-DPNWWKGETHq---G-IGLFPSNFVT 70
gi 74963636   528 VLGEAIAQFAFDG----AQDGTIRMEANEKLWLIEKdeGDGWTRVRKEn--nSaDGFVPSSYLK 585
gi 118572223  487 PIGQCVAIYHFEG----SSEGTVSMSEGEDLSLMEEdkGDGWTRVRRKq---GgEGYVPTSYLR 543
gi 74706678     8 PGTQCITKCEHTR----PKPGELAFRKGDVVTILEAceNKSWYRVKHHt--sGqEGLLAAGALR 65
gi 912989    1052 PKKLVPGKYTVVMddekGGPDTLAMRSGDMVEVVEEgaEGLWYVRDLTs---SkEGWVPASSLS 1112
gi 74837255   915 RQGPVQAICAYKQ------QGQLQIEKGETVTLLDNsgRVKWRVRTAK----GqEGPIPGACLL 968
gi 86560957    32 PYTPGQLTKNFTA----TVADEISVTRGTTVKAIYR--DDQWIYVEVSd---GrKGFVPQTYCK 86
gi 71988334   548 TAVTVTALFEFAK----SSAETMSIEQGEILLVLEHdhGDGWTRTKNCrkhnEeSGFVPTSYLQ 607
gi 19112809   516 SKVDGVVLYDFTG----EHEGVITASEGQEFTLLEPddGSGWVRVKID----GtDGLIPASYVK 571
gi 119608322  634 AIGTCKALYTFEG----QNEGTISVVEGETLYVIEEdkGDGWTRIRRNe---DeEGYVPTSYVE 690
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