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    PRAP1 proline rich acidic protein 1 [ Homo sapiens (human) ]

    Gene ID: 118471, updated on 8-Oct-2018

    Summary

    Official Symbol
    PRAP1provided by HGNC
    Official Full Name
    proline rich acidic protein 1provided by HGNC
    Primary source
    HGNC:HGNC:23304
    See related
    Ensembl:ENSG00000165828 MIM:609776; Vega:OTTHUMG00000019312
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UPA; PRO1195
    Expression
    Biased expression in small intestine (RPKM 388.5), duodenum (RPKM 348.9) and 3 other tissues See more
    Orthologs

    Genomic context

    See PRAP1 in Genome Data Viewer
    Location:
    10q26.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (133347340..133352683)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (135148362..135166187)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene calcyon neuron specific vesicular protein Neighboring gene barrier to autointegration factor 1 pseudogene 2 Neighboring gene fucose mutarotase Neighboring gene enoyl-CoA hydratase, short chain 1 Neighboring gene microRNA 3944

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Autophagy - animal, organism-specific biosystem (from KEGG)
      Autophagy - animal, organism-specific biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • Autophagy - animal, conserved biosystem (from KEGG)
      Autophagy - animal, conserved biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Readthrough ZNF511-PRAP1

    Readthrough gene: ZNF511-PRAP1, Included gene: ZNF511

    Homology

    Clone Names

    • MGC126792

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    proline-rich acidic protein 1
    Names
    epididymis secretory sperm binding protein
    epididymis tissue protein Li 178

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145201.1NP_001138673.1  proline-rich acidic protein 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001138673.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The resulting isoform (2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      AL360181, BC071872, DQ884405
      Consensus CDS
      CCDS44498.1
      UniProtKB/Swiss-Prot
      Q96NZ9
      UniProtKB/TrEMBL
      A6XND8
      Related
      ENSP00000486265.1, OTTHUMP00000278540, ENST00000463201.2, OTTHUMT00000051133
      Conserved Domains (1) summary
      pfam15314
      Location:96140
      PRAP; Proline-rich acidic protein 1, pregnancy-specific uterine
    2. NM_145202.4NP_660203.3  proline-rich acidic protein 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_660203.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL360181, BC071872
      Consensus CDS
      CCDS7679.1
      UniProtKB/Swiss-Prot
      Q96NZ9
      Related
      ENSP00000416126.2, OTTHUMP00000020800, ENST00000433452.5, OTTHUMT00000051132
      Conserved Domains (1) summary
      pfam15314
      Location:105149
      PRAP; Proline-rich acidic protein 1, pregnancy-specific uterine

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

      Range
      133347340..133352683
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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