Prap1 proline-rich acidic protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prap1provided by MGI
Official Full Name: proline-rich acidic protein 1provided by MGI
Primary source: MGI:MGI:893573
See related: Ensembl:ENSMUSG00000025467 AllianceGenome:MGI:893573
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Upa
Summary: Enables triglyceride binding activity. Involved in several processes, including cellular response to X-ray; positive regulation of intestinal lipid absorption; and positive regulation of lipid transport. Located in endoplasmic reticulum and extracellular region. Is expressed in several structures, including female reproductive system; intestine; and lower jaw. Orthologous to human PRAP1 (proline rich acidic protein 1). [provided by Alliance of Genome Resources, Mar 2025]
Expression: Biased expression in duodenum adult (RPKM 1621.5), small intestine adult (RPKM 1435.1) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 7 F4; 7 85.1 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (139673309..139677116)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (140093396..140097203)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Proline-Rich Acidic Protein 1 (PRAP1) Protects the Gastrointestinal Epithelium From Irradiation-Induced Apoptosis.
Title: Proline-Rich Acidic Protein 1 (PRAP1) Protects the Gastrointestinal Epithelium From Irradiation-Induced Apoptosis.
PRAP1 is a novel lipid-binding protein that promotes lipid absorption by facilitating MTTP-mediated lipid transport.
Title: PRAP1 is a novel lipid-binding protein that promotes lipid absorption by facilitating MTTP-mediated lipid transport.
Neutralizing PRAP1 protein causes reduction of implanted embryos.
Title: Estradiol-regulated proline-rich acid protein 1 is repressed by class I histone deacetylase and functions in peri-implantation mouse uterus.
PRAP1 is a marker for successful embryo implantation.
Title: Uterine luminal epithelium-specific proline-rich acidic protein 1 (PRAP1) as a marker for successful embryo implantation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (2) 1 citation

General gene information

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Markers

Prap1 (e-PCR), detects polymorphism
- UniSTS:545866

Upa (e-PCR), detects polymorphism
- UniSTS:144733

Prap1 (e-PCR), detects polymorphism
- UniSTS:495839

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables triglyceride binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA damage response, signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response, signal transduction by p53 class mediator	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to X-ray	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in deactivation of mitotic spindle assembly checkpoint	ISO Inferred from Sequence Orthology more info
involved_in deactivation of mitotic spindle assembly checkpoint	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of intestinal lipid absorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phospholipid transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of triglyceride transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: proline-rich acidic protein 1

Names: pregnancy-specific uterine protein; uterine-specific proline-rich acidic protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.