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    Apc APC, WNT signaling pathway regulator [ Mus musculus (house mouse) ]

    Gene ID: 11789, updated on 12-Mar-2019

    Summary

    Official Symbol
    Apcprovided by MGI
    Official Full Name
    APC, WNT signaling pathway regulatorprovided by MGI
    Primary source
    MGI:MGI:88039
    See related
    Ensembl:ENSMUSG00000005871
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CC1; Min; mAPC; AI047805; AU020952; AW124434
    Expression
    Broad expression in frontal lobe adult (RPKM 29.9), CNS E18 (RPKM 22.5) and 18 other tissues See more
    Orthologs

    Genomic context

    See Apc in Genome Data Viewer
    Location:
    18 B1; 18 18.53 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 18 NC_000084.6 (34220617..34322190)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (34380638..34481844)

    Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene peptidyl-prolyl cis-trans isomerase A pseudogene chr18_319.1 Neighboring gene predicted gene, 41687 Neighboring gene predicted gene, 41686 Neighboring gene ribosomal protein L29 pseudogene Neighboring gene signal recognition particle 19 Neighboring gene receptor accessory protein 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    beta-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    beta-catenin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    beta-catenin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    dynein complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    dynein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    gamma-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    gamma-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule plus-end binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule plus-end binding ISO
    Inferred from Sequence Orthology
    more info
     
    protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    T cell differentiation in thymus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    anterior/posterior pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axis specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axonogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    canonical Wnt signaling pathway involved in negative regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    canonical Wnt signaling pathway involved in positive regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cell cycle arrest ISO
    Inferred from Sequence Orthology
    more info
     
    cell fate specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    chromosome organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    chromosome organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytoplasmic microtubule organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    dorsal/ventral pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment or maintenance of cell polarity ISO
    Inferred from Sequence Orthology
    more info
     
    hair follicle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    metaphase/anaphase transition of mitotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    metaphase/anaphase transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic spindle assembly checkpoint ISO
    Inferred from Sequence Orthology
    more info
     
    muscle cell cellular homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of MAPK cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of canonical Wnt signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of cardiac muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cyclin-dependent protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of epithelial cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of epithelial cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of epithelial cell proliferation involved in prostate gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of microtubule depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of microtubule depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of microtubule depolymerization ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of molecular function TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of odontogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    PubMed 
    neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    pattern specification process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    pattern specification process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of epithelial cell differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of microtubule polymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein localization to centrosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein localization to centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of pseudopodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    PubMed 
    protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    proximal/distal pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of attachment of spindle microtubules to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of attachment of spindle microtubules to kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of glutamate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of microtubule-based process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of nitrogen compound metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of osteoclast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    retina development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    skin development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    somatic stem cell population maintenance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    somatic stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    thymus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Scrib-APC-beta-catenin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axonal growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axonal growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    beta-catenin destruction complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    beta-catenin destruction complex ISO
    Inferred from Sequence Orthology
    more info
     
    bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
     
    catenin complex ISO
    Inferred from Sequence Orthology
    more info
     
    cell body fiber ISO
    Inferred from Sequence Orthology
    more info
     
    cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell projection membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with cell-cell adherens junction ISO
    Inferred from Sequence Orthology
    more info
     
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with cytoplasmic microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with cytoplasmic microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    lateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with microtubule plus-end IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection terminus ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    adenomatous polyposis coli protein
    Names
    adenomatosis polyposis coli
    multiple intestinal neoplasia

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360979.1NP_001347908.1  adenomatous polyposis coli protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC090534, AC114003, AL591373
      Conserved Domains (14) summary
      smart00185
      Location:588628
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:404447
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:15761599
      APC_r; APC repeat
      pfam05924
      Location:19731992
      SAMP; SAMP Motif
      pfam05937
      Location:26112783
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:21642509
      APC_basic; APC basic domain
      pfam11414
      Location:66146
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:671957
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:9751074
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:12221308
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:16011654
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:16851778
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:18121886
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      cl21727
      Location:472673
      VATPase_H; VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The ...
    2. NM_001360980.1NP_001347909.1  adenomatous polyposis coli protein isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC090534, AC114003, AL591373
      Conserved Domains (15) summary
      smart00185
      Location:665705
      ARM; Armadillo/beta-catenin-like repeats
      pfam16689
      Location:455
      APC_N_CC; Coiled-coil N-terminus of APC, dimerisation domain
      sd00043
      Location:579611
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:16531676
      APC_r; APC repeat
      pfam05924
      Location:20502069
      SAMP; SAMP Motif
      pfam05937
      Location:26882860
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:22412586
      APC_basic; APC basic domain
      pfam11414
      Location:125205
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:7481034
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:10521151
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:12991385
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:16781731
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:17621855
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:18891963
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      cl21727
      Location:549750
      VATPase_H; VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The ...
    3. NM_007462.3NP_031488.2  adenomatous polyposis coli protein isoform 3

      See identical proteins and their annotated locations for NP_031488.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an exon in the coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
      Source sequence(s)
      AC090534, AK080907, AL591373, BE623286
      Consensus CDS
      CCDS29125.1
      UniProtKB/TrEMBL
      B2RUG9, Q8BNP7
      Related
      ENSMUSP00000078337.5, ENSMUST00000079362.11
      Conserved Domains (14) summary
      cd00020
      Location:609729
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05923
      Location:16351659
      APC_crr; APC cysteine-rich region
      pfam05924
      Location:20332052
      SAMP; SAMP Motif
      pfam05937
      Location:26702842
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:22232568
      APC_basic; APC basic domain
      pfam11414
      Location:125205
      Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
      pfam16629
      Location:7301017
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:10341133
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:12811367
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:16601716
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:17371837
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:18741945
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      pfam16689
      Location:455
      APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
      sd00043
      Location:463506
      ARM; armadillo repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000084.6 Reference GRCm38.p4 C57BL/6J

      Range
      34220617..34322190
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525529.3XP_006525592.1  adenomatous polyposis coli protein isoform X1

      Conserved Domains (13) summary
      cd00020
      Location:637757
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05923
      Location:16631687
      APC_crr; APC cysteine-rich region
      pfam05924
      Location:20612080
      SAMP; SAMP Motif
      pfam05937
      Location:26982870
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:22512596
      APC_basic; APC basic domain
      pfam11414
      Location:135215
      Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
      pfam16629
      Location:7581045
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:10621161
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:13091395
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:16881744
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:17651865
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:19021973
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      sd00043
      Location:589621
      ARM; armadillo repeat [structural motif]
    2. XM_006525534.3XP_006525597.1  adenomatous polyposis coli protein isoform X5

      Conserved Domains (13) summary
      cd00020
      Location:602722
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05923
      Location:16281652
      APC_crr; APC cysteine-rich region
      pfam05924
      Location:20262045
      SAMP; SAMP Motif
      pfam05937
      Location:26632835
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:22162561
      APC_basic; APC basic domain
      pfam11414
      Location:135215
      Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
      pfam16629
      Location:7231010
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:10271126
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:12741360
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:16531709
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:17301830
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:18671938
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      sd00043
      Location:554586
      ARM; armadillo repeat [structural motif]
    3. XM_006525532.3XP_006525595.1  adenomatous polyposis coli protein isoform X3

      See identical proteins and their annotated locations for XP_006525595.1

      Conserved Domains (13) summary
      cd00020
      Location:619739
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05923
      Location:16451669
      APC_crr; APC cysteine-rich region
      pfam05924
      Location:20432062
      SAMP; SAMP Motif
      pfam05937
      Location:26802852
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:22332578
      APC_basic; APC basic domain
      pfam11414
      Location:135215
      Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
      pfam16629
      Location:7401027
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:10441143
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:12911377
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:16701726
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:17471847
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:18841955
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      sd00043
      Location:473516
      ARM; armadillo repeat [structural motif]
    4. XM_006525538.3XP_006525601.1  adenomatous polyposis coli protein isoform X8

      Conserved Domains (13) summary
      cd00020
      Location:536656
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05923
      Location:15621586
      APC_crr; APC cysteine-rich region
      pfam05924
      Location:19601979
      SAMP; SAMP Motif
      pfam05937
      Location:25972769
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:21502495
      APC_basic; APC basic domain
      pfam11414
      Location:135215
      Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
      pfam16629
      Location:657944
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:9611060
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:12081294
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:15871643
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:16641764
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:18011872
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      sd00043
      Location:488520
      ARM; armadillo repeat [structural motif]
    5. XM_006525530.1XP_006525593.1  adenomatous polyposis coli protein isoform X2

      See identical proteins and their annotated locations for XP_006525593.1

      Conserved Domains (15) summary
      smart00185
      Location:665705
      ARM; Armadillo/beta-catenin-like repeats
      pfam16689
      Location:455
      APC_N_CC; Coiled-coil N-terminus of APC, dimerisation domain
      sd00043
      Location:579611
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:16531676
      APC_r; APC repeat
      pfam05924
      Location:20502069
      SAMP; SAMP Motif
      pfam05937
      Location:26882860
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:22412586
      APC_basic; APC basic domain
      pfam11414
      Location:125205
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:7481034
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:10521151
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:12991385
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:16781731
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:17621855
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:18891963
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      cl21727
      Location:549750
      VATPase_H; VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The ...
    6. XM_006525539.2XP_006525602.1  adenomatous polyposis coli protein isoform X9

      Conserved Domains (14) summary
      cd00020
      Location:508628
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05923
      Location:15341558
      APC_crr; APC cysteine-rich region
      pfam05924
      Location:19321951
      SAMP; SAMP Motif
      pfam05937
      Location:25692741
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:21222467
      APC_basic; APC basic domain
      pfam11414
      Location:125205
      Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
      pfam16629
      Location:629916
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:9331032
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:11801266
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:15591615
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:16361736
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:17731844
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      pfam16689
      Location:455
      APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
      sd00043
      Location:362405
      ARM; armadillo repeat [structural motif]
    7. XM_006525533.2XP_006525596.1  adenomatous polyposis coli protein isoform X4

      Conserved Domains (13) summary
      cd00020
      Location:607727
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05923
      Location:16331657
      APC_crr; APC cysteine-rich region
      pfam05924
      Location:20312050
      SAMP; SAMP Motif
      pfam05937
      Location:26682840
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:22212566
      APC_basic; APC basic domain
      pfam11414
      Location:105185
      Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
      pfam16629
      Location:7281015
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:10321131
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:12791365
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:16581714
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:17351835
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:18721943
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      sd00043
      Location:559591
      ARM; armadillo repeat [structural motif]
    8. XM_006525536.3XP_006525599.1  adenomatous polyposis coli protein isoform X6

      See identical proteins and their annotated locations for XP_006525599.1

      Conserved Domains (13) summary
      cd00020
      Location:568688
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05923
      Location:15941618
      APC_crr; APC cysteine-rich region
      pfam05924
      Location:19922011
      SAMP; SAMP Motif
      pfam05937
      Location:26292801
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:21822527
      APC_basic; APC basic domain
      pfam11414
      Location:66146
      Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
      pfam16629
      Location:689976
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:9931092
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:12401326
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:16191675
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:16961796
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:18331904
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      sd00043
      Location:520552
      ARM; armadillo repeat [structural motif]
    9. XM_017317804.1XP_017173293.1  adenomatous polyposis coli protein isoform X7

      Conserved Domains (14) summary
      smart00185
      Location:588628
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:404447
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:15761599
      APC_r; APC repeat
      pfam05924
      Location:19731992
      SAMP; SAMP Motif
      pfam05937
      Location:26112783
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:21642509
      APC_basic; APC basic domain
      pfam11414
      Location:66146
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:671957
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:9751074
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:12221308
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:16011654
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:16851778
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:18121886
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      cl21727
      Location:472673
      VATPase_H; VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The ...
    10. XM_006525531.1XP_006525594.1  adenomatous polyposis coli protein isoform X2

      Conserved Domains (15) summary
      smart00185
      Location:665705
      ARM; Armadillo/beta-catenin-like repeats
      pfam16689
      Location:455
      APC_N_CC; Coiled-coil N-terminus of APC, dimerisation domain
      sd00043
      Location:579611
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:16531676
      APC_r; APC repeat
      pfam05924
      Location:20502069
      SAMP; SAMP Motif
      pfam05937
      Location:26882860
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:22412586
      APC_basic; APC basic domain
      pfam11414
      Location:125205
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:7481034
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:10521151
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:12991385
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:16781731
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:17621855
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:18891963
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      cl21727
      Location:549750
      VATPase_H; VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The ...
    11. XM_006525535.1XP_006525598.1  adenomatous polyposis coli protein isoform X6

      See identical proteins and their annotated locations for XP_006525598.1

      Conserved Domains (13) summary
      cd00020
      Location:568688
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05923
      Location:15941618
      APC_crr; APC cysteine-rich region
      pfam05924
      Location:19922011
      SAMP; SAMP Motif
      pfam05937
      Location:26292801
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:21822527
      APC_basic; APC basic domain
      pfam11414
      Location:66146
      Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
      pfam16629
      Location:689976
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:9931092
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:12401326
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:16191675
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:16961796
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:18331904
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      sd00043
      Location:520552
      ARM; armadillo repeat [structural motif]
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