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NCAPD2 non-SMC condensin I complex subunit D2 [ Homo sapiens (human) ]

Gene ID: 9918, updated on 17-Jun-2019

Summary

Official Symbol
NCAPD2provided by HGNC
Official Full Name
non-SMC condensin I complex subunit D2provided by HGNC
Primary source
HGNC:HGNC:24305
See related
Ensembl:ENSG00000010292 MIM:615638
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CNAP1; CAP-D2; MCPH21; hCAP-D2
Expression
Ubiquitous expression in lymph node (RPKM 20.3), bone marrow (RPKM 14.5) and 24 other tissues See more
Orthologs

Genomic context

See NCAPD2 in Genome Data Viewer
Location:
12p13.31
Exon count:
32
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (6494102..6531955)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (6602547..6641132)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene plakophilin 2 pseudogene 1 Neighboring gene mitochondrial ribosomal protein L51 Neighboring gene small Cajal body-specific RNA 10 Neighboring gene uncharacterized LOC112268089 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase Neighboring gene intermediate filament family orphan 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Interaction of HIV-1 Tat with CAPD2 in T-cells is identified by a proteomic strategy based on affinity chromatography coupled with mass spectrometry PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Aurora B signaling, organism-specific biosystem (from Pathway Interaction Database)
    Aurora B signaling, organism-specific biosystem
    Aurora B signaling
  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • Condensation of Prometaphase Chromosomes, organism-specific biosystem (from REACTOME)
    Condensation of Prometaphase Chromosomes, organism-specific biosystemThe condensin I complex is evolutionarily conserved and consists of five subunits: two SMC (structural maintenance of chromosomes) family subunits, SMC2 and SMC4, and three non-SMC subunits, NCAPD2, ...
  • M Phase, organism-specific biosystem (from REACTOME)
    M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
  • Mitotic Prometaphase, organism-specific biosystem (from REACTOME)
    Mitotic Prometaphase, organism-specific biosystemThe dissolution of the nuclear membrane marks the beginning of the prometaphase. Kinetochores are created when proteins attach to the centromeres. Microtubules then attach at the kinetochores, and th...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0159

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone binding IDA
Inferred from Direct Assay
more info
PubMed 
histone binding NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell division IEA
Inferred from Electronic Annotation
more info
 
chromosome separation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
meiotic chromosome condensation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic chromosome condensation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic chromosome condensation IDA
Inferred from Direct Assay
more info
PubMed 
mitotic chromosome condensation IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic chromosome condensation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
condensed chromosome IDA
Inferred from Direct Assay
more info
PubMed 
condensed chromosome, centromeric region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
condensin complex IDA
Inferred from Direct Assay
more info
PubMed 
condensin core heterodimer NAS
Non-traceable Author Statement
more info
PubMed 
colocalizes_with cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
membrane HDA PubMed 
colocalizes_with nuclear chromosome IDA
Inferred from Direct Assay
more info
PubMed 
nuclear condensin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
condensin complex subunit 1
Names
XCAP-D2 homolog
chromosome condensation-related SMC-associated protein 1
chromosome-associated protein D2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014865.4NP_055680.3  condensin complex subunit 1

    See identical proteins and their annotated locations for NP_055680.3

    Status: VALIDATED

    Source sequence(s)
    AC006064, AK022511, AK128354, AL548223, BC028182, CN307514, D63880
    Consensus CDS
    CCDS8548.1
    UniProtKB/Swiss-Prot
    Q15021
    UniProtKB/TrEMBL
    B3KMS0, B3KY03
    Related
    ENSP00000325017.5, ENST00000315579.10
    Conserved Domains (3) summary
    COG5098
    Location:601245
    COG5098; Chromosome condensation complex Condensin, subunit D2 [Chromatin structure and dynamics / Cell division and chromosome partitioning]
    pfam12717
    Location:10691234
    Cnd1; non-SMC mitotic condensation complex subunit 1
    pfam12922
    Location:75240
    Cnd1_N; non-SMC mitotic condensation complex subunit 1, N-term

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    6494102..6531955
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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