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Ncapd2 non-SMC condensin I complex, subunit D2 [ Mus musculus (house mouse) ]

Gene ID: 68298, updated on 8-Feb-2024

Summary

Official Symbol
Ncapd2provided by MGI
Official Full Name
non-SMC condensin I complex, subunit D2provided by MGI
Primary source
MGI:MGI:1915548
See related
Ensembl:ENSMUSG00000038252 AllianceGenome:MGI:1915548
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CNAP1; CAP-D2; mKIAA0159; 2810406C15Rik; 2810465G24Rik
Summary
Predicted to enable histone binding activity. Predicted to be involved in meiotic chromosome condensation and mitotic chromosome condensation. Predicted to act upstream of or within cell division and chromosome condensation. Located in condensed chromosome and pronucleus. Part of condensin complex. Is expressed in central nervous system; retina outer nuclear layer; and salivary gland. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly. Orthologous to human NCAPD2 (non-SMC condensin I complex subunit D2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 53.3), thymus adult (RPKM 40.7) and 24 other tissues See more
Orthologs
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Genomic context

See Ncapd2 in Genome Data Viewer
Location:
6 F2- F3; 6 59.32 cM
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (125144970..125169062, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (125168007..125192100, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene intermediate filament family orphan 1 Neighboring gene STARR-seq mESC enhancer starr_17330 Neighboring gene STARR-positive B cell enhancer ABC_E2207 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase Neighboring gene small Cajal body-specific RNA 10 Neighboring gene STARR-seq mESC enhancer starr_17334 Neighboring gene STARR-seq mESC enhancer starr_17335 Neighboring gene mitochondrial ribosomal protein L51 Neighboring gene microRNA 3098

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0159, MGC39046

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables histone binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within chromosome condensation IEA
Inferred from Electronic Annotation
more info
 
involved_in chromosome condensation IEA
Inferred from Electronic Annotation
more info
 
involved_in meiotic chromosome condensation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in mitotic chromosome condensation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic chromosome condensation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chromosome condensation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chromosome segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of chromosome separation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in condensed chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in condensed chromosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in condensed chromosome, centromeric region IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in condensed nuclear chromosome IDA
Inferred from Direct Assay
more info
PubMed 
part_of condensin complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of condensin complex ISO
Inferred from Sequence Orthology
more info
 
part_of condensin complex NAS
Non-traceable Author Statement
more info
PubMed 
part_of condensin complex TAS
Traceable Author Statement
more info
PubMed 
colocalizes_with cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with nuclear chromosome ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in pronucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
condensin complex subunit 1
Names
XCAP-D2 homolog
chromosome condensation-related SMC-associated protein 1
chromosome-associated protein D2
mCAP-D2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417657.1NP_001404586.1  condensin complex subunit 1

    Status: VALIDATED

    Source sequence(s)
    AC166162
    UniProtKB/Swiss-Prot
    Q6ZQI1, Q8K2Z4, Q8R0F2, Q8R3H0, Q922B7, Q923A3, Q9CS25, Q9CT32
    UniProtKB/TrEMBL
    A0A0R4J0H7
  2. NM_146171.2NP_666283.1  condensin complex subunit 1

    See identical proteins and their annotated locations for NP_666283.1

    Status: VALIDATED

    Source sequence(s)
    AC166162
    Consensus CDS
    CCDS39636.1
    UniProtKB/Swiss-Prot
    Q6ZQI1, Q8K2Z4, Q8R0F2, Q8R3H0, Q922B7, Q923A3, Q9CS25, Q9CT32
    UniProtKB/TrEMBL
    A0A0R4J0H7
    Related
    ENSMUSP00000042260.5, ENSMUST00000043848.11
    Conserved Domains (2) summary
    COG5098
    Location:1851235
    COG5098; Chromosome condensation complex Condensin, subunit D2 [Chromatin structure and dynamics / Cell division and chromosome partitioning]
    pfam12922
    Location:75240
    Cnd1_N; non-SMC mitotic condensation complex subunit 1, N-term

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    125144970..125169062 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506532.4XP_006506595.1  condensin complex subunit 1 isoform X2

    UniProtKB/Swiss-Prot
    Q6ZQI1, Q8K2Z4, Q8R0F2, Q8R3H0, Q922B7, Q923A3, Q9CS25, Q9CT32
    Conserved Domains (2) summary
    COG5098
    Location:671117
    COG5098; Chromosome condensation complex Condensin, subunit D2 [Chromatin structure and dynamics / Cell division and chromosome partitioning]
    pfam12922
    Location:1122
    Cnd1_N; non-SMC mitotic condensation complex subunit 1, N-term
  2. XM_006506533.4XP_006506596.1  condensin complex subunit 1 isoform X3

    Conserved Domains (2) summary
    COG5098
    Location:185728
    COG5098; Chromosome condensation complex Condensin, subunit D2 [Chromatin structure and dynamics / Cell division and chromosome partitioning]
    pfam12922
    Location:75240
    Cnd1_N; non-SMC mitotic condensation complex subunit 1, N-term

RNA

  1. XR_004933619.1 RNA Sequence