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PLoS One. 2011;6(8):e23548. doi: 10.1371/journal.pone.0023548. Epub 2011 Aug 12.

Condensin I recruitment to base damage-enriched DNA lesions is modulated by PARP1.

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1
Department of Biological Chemistry, School of Medicine, University of California Irvine, Irvine, California, United States of America.

Abstract

Condensin I is important for chromosome organization and segregation in mitosis. We previously showed that condensin I also interacts with PARP1 in response to DNA damage and plays a role in single-strand break repair. However, whether condensin I physically associates with DNA damage sites and how PARP1 may contribute to this process were unclear. We found that condensin I is preferentially recruited to DNA damage sites enriched for base damage. This process is dictated by PARP1 through its interaction with the chromosome-targeting domain of the hCAP-D2 subunit of condensin I.

PMID:
21858164
PMCID:
PMC3155556
DOI:
10.1371/journal.pone.0023548
[Indexed for MEDLINE]
Free PMC Article

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