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PCLAF PCNA clamp associated factor [ Homo sapiens (human) ]

Gene ID: 9768, updated on 13-Mar-2020

Summary

Official Symbol
PCLAFprovided by HGNC
Official Full Name
PCNA clamp associated factorprovided by HGNC
Primary source
HGNC:HGNC:28961
See related
Ensembl:ENSG00000166803 MIM:610696
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L5; PAF; OEATC; PAF15; OEATC1; p15PAF; NS5ATP9; OEATC-1; p15/PAF; KIAA0101; p15(PAF)
Expression
Biased expression in bone marrow (RPKM 26.4), lymph node (RPKM 13.8) and 11 other tissues See more
Orthologs

Genomic context

See PCLAF in Genome Data Viewer
Location:
15q22.31
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (64364304..64387687, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (64657193..64679914, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene casein kinase 1 gamma 1 Neighboring gene sorting nexin 22 Neighboring gene peptidylprolyl isomerase B Neighboring gene Sharpr-MPRA regulatory region 12494 Neighboring gene thyroid hormone receptor interactor 4 Neighboring gene uncharacterized LOC105370861 Neighboring gene zinc finger protein 609 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 61

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ58702, KIAA0101

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA replication IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
centrosome cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to UV IDA
Inferred from Direct Assay
more info
PubMed 
translesion synthesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translesion synthesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
translesion synthesis TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
centrosome IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
PCNA-associated factor
Names
HCV NS5A-transactivated protein 9
PCNA-associated factor of 15 kDa
hepatitis C virus NS5A-transactivated protein 9
overexpressed in anaplastic thyroid carcinoma 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001029989.3NP_001025160.1  PCNA-associated factor isoform 2

    See identical proteins and their annotated locations for NP_001025160.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the central coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC087632, AV757440, BC005832
    Consensus CDS
    CCDS32269.1
    UniProtKB/Swiss-Prot
    Q15004
    Related
    ENSP00000369608.2, ENST00000380258.6
    Conserved Domains (1) summary
    pfam15715
    Location:127
    PAF; PCNA-associated factor
  2. NM_014736.6NP_055551.1  PCNA-associated factor isoform 1

    See identical proteins and their annotated locations for NP_055551.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC087632, BC005832, BF691807
    Consensus CDS
    CCDS10193.1
    UniProtKB/Swiss-Prot
    Q15004
    Related
    ENSP00000300035.4, ENST00000300035.9
    Conserved Domains (1) summary
    pfam15715
    Location:174
    PAF; PCNA-associated factor

RNA

  1. NR_109934.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5'-terminal exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AC087632, BC005832, DT220867

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    64364304..64387687 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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