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CSNK1G1 casein kinase 1 gamma 1 [ Homo sapiens (human) ]

Gene ID: 53944, updated on 1-Aug-2020

Summary

Official Symbol
CSNK1G1provided by HGNC
Official Full Name
casein kinase 1 gamma 1provided by HGNC
Primary source
HGNC:HGNC:2454
See related
Ensembl:ENSG00000169118 MIM:606274
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CK1gamma1
Summary
This gene encodes a member of the casein kinase I gene family. This family is comprised of serine/threonine kinases that phosphorylate acidic proteins such as caseins. The encoded kinase plays a role in cell cycle checkpoint arrest in response to stalled replication forks by phosphorylating Claspin. A mutation in this gene may be associated with non-syndromic early-onset epilepsy (NSEOE). [provided by RefSeq, Jul 2016]
Expression
Ubiquitous expression in testis (RPKM 6.6), thyroid (RPKM 4.2) and 25 other tissues See more
Orthologs

Genomic context

See CSNK1G1 in Genome Data Viewer
Location:
15q22.31
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (64165525..64356173, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (64457716..64665968, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene sorting nexin 1 Neighboring gene sorting nexin 22 Neighboring gene peptidylprolyl isomerase B Neighboring gene Sharpr-MPRA regulatory region 12494 Neighboring gene PCNA clamp associated factor Neighboring gene thyroid hormone receptor interactor 4 Neighboring gene uncharacterized LOC105370861

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Casein kinase 1 gamma 1 reduces HIV-1 infectivity by affecting Gag processing PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: PCLAF

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
casein kinase I isoform gamma-1
NP_001316534.1
NP_001316535.1
NP_001316536.1
NP_071331.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051236.1 RefSeqGene

    Range
    5087..195735
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001329605.2NP_001316534.1  casein kinase I isoform gamma-1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame exon and uses an alternate splice site, both in the 3' coding region, compared to variant 1. The encoded isoform (2) is longer and contains a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK225960, BE644696
    Consensus CDS
    CCDS86465.1
    UniProtKB/TrEMBL
    U3KQB3
    Related
    ENSP00000475724.1, ENST00000607537.6
  2. NM_001329606.2NP_001316535.1  casein kinase I isoform gamma-1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Both variants 1 and 4 encode the same isoform (1).
    Source sequence(s)
    AC087632, AC100840, AC110054
    Consensus CDS
    CCDS10192.2
    UniProtKB/Swiss-Prot
    Q9HCP0
    UniProtKB/TrEMBL
    A0A024R5W3
    Related
    ENSP00000489165.1, ENST00000635142.1
    Conserved Domains (2) summary
    cd14126
    Location:43331
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:331381
    CK1gamma_C; Casein kinase 1 gamma C terminal
  3. NM_001329607.2NP_001316536.1  casein kinase I isoform gamma-1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region compared to variant 1. The encoded isoform (3) contains a longer and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC087632, AC100840, AC110054
    Consensus CDS
    CCDS86464.1
    UniProtKB/TrEMBL
    Q8IXA3
    Related
    ENSP00000476088.2, ENST00000561349.6
    Conserved Domains (2) summary
    cd14126
    Location:43331
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:331381
    CK1gamma_C; Casein kinase 1 gamma C terminal
  4. NM_022048.5NP_071331.2  casein kinase I isoform gamma-1 isoform 1

    See identical proteins and their annotated locations for NP_071331.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the shortest isoform (1). Both variants 1 and 4 encode the same isoform (1).
    Source sequence(s)
    AC100840, AL832551, BC077731, BE644696, DB094870
    Consensus CDS
    CCDS10192.2
    UniProtKB/Swiss-Prot
    Q9HCP0
    UniProtKB/TrEMBL
    A0A024R5W3
    Related
    ENSP00000305777.7, ENST00000303052.13
    Conserved Domains (2) summary
    cd14126
    Location:43331
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:331381
    CK1gamma_C; Casein kinase 1 gamma C terminal

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    64165525..64356173 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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