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ZNF536 zinc finger protein 536 [ Homo sapiens (human) ]

Gene ID: 9745, updated on 2-Oct-2018

Summary

Official Symbol
ZNF536provided by HGNC
Official Full Name
zinc finger protein 536provided by HGNC
Primary source
HGNC:HGNC:29025
See related
Ensembl:ENSG00000198597 MIM:618037; Vega:OTTHUMG00000182112
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a highly conserved zinc finger protein. The encoded protein is most abundant in brain, where it negatively regulates neuronal differentiation. [provided by RefSeq, Sep 2015]
Expression
Biased expression in brain (RPKM 2.6), thyroid (RPKM 0.8) and 11 other tissues See more
Orthologs

Genomic context

See ZNF536 in Genome Data Viewer
Location:
19q12
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (30224236..30713586)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (30863328..31048966)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs382 Neighboring gene uncharacterized LOC107985271 Neighboring gene VISTA enhancer hs721 Neighboring gene VISTA enhancer hs858 Neighboring gene VISTA enhancer hs383 Neighboring gene VISTA enhancer hs430 Neighboring gene VISTA enhancer hs384 Neighboring gene uncharacterized LOC105372354 Neighboring gene long intergenic non-protein coding RNA 1834

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.
NHGRI GWA Catalog
Biological insights from 108 schizophrenia-associated genetic loci.
NHGRI GWA Catalog
Genome-wide association analysis demonstrates the highly polygenic character of age-related hearing impairment.
NHGRI GWA Catalog
Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
NHGRI GWA Catalog
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
NHGRI GWA Catalog
Genome-wide association with select biomarker traits in the Framingham Heart Study.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of zinc finger protein 536 (ZNF536) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0390

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001352260.1NP_001339189.1  zinc finger protein 536 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC011454, AC011478, AC011504, AC011532, DA205038, DT215826, HY151164, HY309977
    Conserved Domains (6) summary
    COG5048
    Location:103180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:753773
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:753773
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:765787
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:779802
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657735
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers
  2. NM_014717.2NP_055532.1  zinc finger protein 536 isoform 1

    See identical proteins and their annotated locations for NP_055532.1

    Status: REVIEWED

    Source sequence(s)
    BC146757, HY151164
    Consensus CDS
    CCDS32984.1
    UniProtKB/Swiss-Prot
    O15090
    Related
    ENSP00000347730.1, OTTHUMP00000268505, ENST00000355537.3, OTTHUMT00000459667
    Conserved Domains (5) summary
    COG5048
    Location:103180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:753773
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:753773
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:765787
    zf-H2C2_2; Zinc-finger double domain
    pfam16606
    Location:657735
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    30224236..30713586
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527555.2XP_011525857.1  zinc finger protein 536 isoform X1

    See identical proteins and their annotated locations for XP_011525857.1

    Conserved Domains (6) summary
    COG5048
    Location:103180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132152
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:753773
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:145169
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:13321355
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657735
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers
  2. XM_011527554.2XP_011525856.1  zinc finger protein 536 isoform X1

    See identical proteins and their annotated locations for XP_011525856.1

    Conserved Domains (6) summary
    COG5048
    Location:103180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132152
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:753773
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:145169
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:13321355
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657735
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers
  3. XM_017027532.1XP_016883021.1  zinc finger protein 536 isoform X1

    Conserved Domains (6) summary
    COG5048
    Location:103180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132152
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:753773
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:145169
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:13321355
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657735
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers
  4. XM_017027531.1XP_016883020.1  zinc finger protein 536 isoform X1

    Conserved Domains (6) summary
    COG5048
    Location:103180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132152
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:753773
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:145169
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:13321355
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657735
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers
  5. XM_017027533.1XP_016883022.1  zinc finger protein 536 isoform X1

    Conserved Domains (6) summary
    COG5048
    Location:103180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132152
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:753773
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:145169
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:13321355
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657735
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers
  6. XM_017027530.1XP_016883019.1  zinc finger protein 536 isoform X1

    Conserved Domains (6) summary
    COG5048
    Location:103180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132152
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:753773
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:145169
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:13321355
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657735
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers
  7. XM_017027535.1XP_016883024.1  zinc finger protein 536 isoform X1

    Conserved Domains (6) summary
    COG5048
    Location:103180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132152
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:753773
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:145169
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:13321355
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657735
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers
  8. XM_024451807.1XP_024307575.1  zinc finger protein 536 isoform X1

    Conserved Domains (6) summary
    COG5048
    Location:103180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132152
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:753773
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:145169
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:13321355
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657735
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers
  9. XM_017027529.1XP_016883018.1  zinc finger protein 536 isoform X1

    Conserved Domains (6) summary
    COG5048
    Location:103180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132152
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:753773
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:145169
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:13321355
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657735
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers
  10. XM_017027534.1XP_016883023.1  zinc finger protein 536 isoform X1

    Conserved Domains (6) summary
    COG5048
    Location:103180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132152
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:753773
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:145169
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:13321355
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657735
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers
  11. XM_017027538.1XP_016883027.1  zinc finger protein 536 isoform X3

  12. XM_017027527.1XP_016883016.1  zinc finger protein 536 isoform X1

    Conserved Domains (6) summary
    COG5048
    Location:103180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132152
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:753773
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:145169
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:13321355
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657735
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers
  13. XM_017027537.1XP_016883026.1  zinc finger protein 536 isoform X2

    Conserved Domains (5) summary
    COG5048
    Location:103180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:753773
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:753773
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:765787
    zf-H2C2_2; Zinc-finger double domain
    pfam16606
    Location:657735
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers
  14. XM_017027528.1XP_016883017.1  zinc finger protein 536 isoform X1

    Conserved Domains (6) summary
    COG5048
    Location:103180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132152
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:753773
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:145169
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:13321355
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657735
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers
  15. XM_017027536.1XP_016883025.1  zinc finger protein 536 isoform X1

    Conserved Domains (6) summary
    COG5048
    Location:103180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132152
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:753773
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:145169
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:13321355
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657735
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers
  16. XM_011527558.2XP_011525860.1  zinc finger protein 536 isoform X1

    See identical proteins and their annotated locations for XP_011525860.1

    Conserved Domains (6) summary
    COG5048
    Location:103180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132152
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:753773
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:145169
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:13321355
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657735
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers
  17. XM_017027539.1XP_016883028.1  zinc finger protein 536 isoform X4

  18. XM_017027540.1XP_016883029.1  zinc finger protein 536 isoform X5

    Conserved Domains (6) summary
    COG5048
    Location:103180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:753773
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:753773
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:765787
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:779802
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657735
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers
  19. XM_017027542.1XP_016883031.1  zinc finger protein 536 isoform X6

    UniProtKB/Swiss-Prot
    O15090
    Conserved Domains (5) summary
    COG5048
    Location:103180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:753773
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:753773
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:765787
    zf-H2C2_2; Zinc-finger double domain
    pfam16606
    Location:657735
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers
  20. XM_011527557.2XP_011525859.1  zinc finger protein 536 isoform X1

    See identical proteins and their annotated locations for XP_011525859.1

    Conserved Domains (6) summary
    COG5048
    Location:103180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132152
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:753773
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:145169
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:13321355
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657735
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers
  21. XM_011527560.2XP_011525862.1  zinc finger protein 536 isoform X2

    Conserved Domains (5) summary
    COG5048
    Location:103180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:753773
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:753773
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:765787
    zf-H2C2_2; Zinc-finger double domain
    pfam16606
    Location:657735
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers
  22. XM_017027543.2XP_016883032.1  zinc finger protein 536 isoform X7

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