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ZNF536 zinc finger protein 536 [ Homo sapiens (human) ]

Gene ID: 9745, updated on 26-Oct-2022

Summary

Official Symbol
ZNF536provided by HGNC
Official Full Name
zinc finger protein 536provided by HGNC
Primary source
HGNC:HGNC:29025
See related
Ensembl:ENSG00000198597 MIM:618037; AllianceGenome:HGNC:29025
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a highly conserved zinc finger protein. The encoded protein is most abundant in brain, where it negatively regulates neuronal differentiation. [provided by RefSeq, Sep 2015]
Expression
Biased expression in brain (RPKM 2.6), thyroid (RPKM 0.8) and 11 other tissues See more
Orthologs
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Try the new Transcript table

Genomic context

See ZNF536 in Genome Data Viewer
Location:
19q12
Exon count:
20
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (30225592..30713586)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (32746044..33234121)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (30716499..31204493)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs382 Neighboring gene uncharacterized LOC107985271 Neighboring gene VISTA enhancer hs721 Neighboring gene VISTA enhancer hs858 Neighboring gene VISTA enhancer hs383 Neighboring gene VISTA enhancer hs430 Neighboring gene VISTA enhancer hs384 Neighboring gene uncharacterized LOC124904685 Neighboring gene uncharacterized LOC105372354 Neighboring gene long intergenic non-protein coding RNA 1834

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.
EBI GWAS Catalog
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog
Genome-wide association analysis demonstrates the highly polygenic character of age-related hearing impairment.
EBI GWAS Catalog
Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
EBI GWAS Catalog
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
EBI GWAS Catalog
Genome-wide association with select biomarker traits in the Framingham Heart Study.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of zinc finger protein 536 (ZNF536) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0390

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001352260.2NP_001339189.1  zinc finger protein 536 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC011454, AC011478, AC011504, AC011532, DA205038, DT215826, HY151164, HY309977
    Consensus CDS
    CCDS92576.1
    Related
    ENSP00000516233.1, ENST00000706150.1
    Conserved Domains (6) summary
    COG5048
    Location:103180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:753773
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:753773
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:765787
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:779802
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657737
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers
  2. NM_001376110.1NP_001363039.1  zinc finger protein 536 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC005597, AC006506, AC011454, AC011504, AC011532
    Consensus CDS
    CCDS92577.1
    Conserved Domains (6) summary
    COG5048
    Location:103180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:753773
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:753773
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:765787
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:779802
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657737
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers
  3. NM_001376111.1NP_001363040.1  zinc finger protein 536 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC005597, AC006506, AC011454, AC011504, AC011532
    Consensus CDS
    CCDS92577.1
    Conserved Domains (6) summary
    COG5048
    Location:103180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:753773
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:753773
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:765787
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:779802
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657737
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers
  4. NM_014717.3NP_055532.1  zinc finger protein 536 isoform 1

    See identical proteins and their annotated locations for NP_055532.1

    Status: REVIEWED

    Source sequence(s)
    AC011454, BC146757, HY151164
    Consensus CDS
    CCDS32984.1
    UniProtKB/Swiss-Prot
    A2RU18, O15090
    Related
    ENSP00000347730.1, ENST00000355537.4
    Conserved Domains (6) summary
    COG5048
    Location:103180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:753773
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:753773
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:765787
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:779802
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657737
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    30225592..30713586
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439770.1XP_047295726.1  zinc finger protein 536 isoform X2

  2. XM_011527554.3XP_011525856.1  zinc finger protein 536 isoform X1

    See identical proteins and their annotated locations for XP_011525856.1

    Conserved Domains (6) summary
    COG5048
    Location:103180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132152
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:753773
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:145169
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:808831
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657737
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers
  3. XM_047439763.1XP_047295719.1  zinc finger protein 536 isoform X1

  4. XM_047439779.1XP_047295735.1  zinc finger protein 536 isoform X5

    UniProtKB/Swiss-Prot
    A2RU18
  5. XM_047439781.1XP_047295737.1  zinc finger protein 536 isoform X5

    UniProtKB/Swiss-Prot
    A2RU18
  6. XM_047439774.1XP_047295730.1  zinc finger protein 536 isoform X4

  7. XM_047439775.1XP_047295731.1  zinc finger protein 536 isoform X5

    UniProtKB/Swiss-Prot
    A2RU18
    Related
    ENSP00000516228.1, ENST00000706144.1
  8. XM_047439776.1XP_047295732.1  zinc finger protein 536 isoform X5

    UniProtKB/Swiss-Prot
    A2RU18
  9. XM_017027532.2XP_016883021.1  zinc finger protein 536 isoform X1

    Conserved Domains (6) summary
    COG5048
    Location:103180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132152
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:753773
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:145169
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:808831
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657737
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers
  10. XM_047439765.1XP_047295721.1  zinc finger protein 536 isoform X1

  11. XM_017027531.2XP_016883020.1  zinc finger protein 536 isoform X1

    Conserved Domains (6) summary
    COG5048
    Location:103180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132152
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:753773
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:145169
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:808831
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657737
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers
  12. XM_047439764.1XP_047295720.1  zinc finger protein 536 isoform X1

  13. XM_047439767.1XP_047295723.1  zinc finger protein 536 isoform X2

  14. XM_047439769.1XP_047295725.1  zinc finger protein 536 isoform X2

  15. XM_047439778.1XP_047295734.1  zinc finger protein 536 isoform X5

    UniProtKB/Swiss-Prot
    A2RU18
  16. XM_047439780.1XP_047295736.1  zinc finger protein 536 isoform X5

    UniProtKB/Swiss-Prot
    A2RU18
  17. XM_047439785.1XP_047295741.1  zinc finger protein 536 isoform X5

    UniProtKB/Swiss-Prot
    A2RU18
  18. XM_017027533.2XP_016883022.1  zinc finger protein 536 isoform X1

    Conserved Domains (6) summary
    COG5048
    Location:103180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132152
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:753773
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:145169
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:808831
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657737
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers
  19. XM_047439772.1XP_047295728.1  zinc finger protein 536 isoform X2

    Related
    ENSP00000467909.3, ENST00000592773.3
  20. XM_017027535.2XP_016883024.1  zinc finger protein 536 isoform X1

    Conserved Domains (6) summary
    COG5048
    Location:103180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132152
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:753773
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:145169
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:808831
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657737
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers
  21. XM_047439783.1XP_047295739.1  zinc finger protein 536 isoform X5

    UniProtKB/Swiss-Prot
    A2RU18
    Related
    ENSP00000516229.1, ENST00000706146.1
  22. XM_047439784.1XP_047295740.1  zinc finger protein 536 isoform X5

    UniProtKB/Swiss-Prot
    A2RU18
  23. XM_047439773.1XP_047295729.1  zinc finger protein 536 isoform X2

  24. XM_047439766.1XP_047295722.1  zinc finger protein 536 isoform X1

  25. XM_017027530.2XP_016883019.1  zinc finger protein 536 isoform X1

    Conserved Domains (6) summary
    COG5048
    Location:103180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132152
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:753773
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:145169
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:808831
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657737
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers
  26. XM_024451807.2XP_024307575.1  zinc finger protein 536 isoform X1

    Conserved Domains (6) summary
    COG5048
    Location:103180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132152
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:753773
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:145169
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:808831
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657737
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers
  27. XM_017027529.2XP_016883018.1  zinc finger protein 536 isoform X1

    Conserved Domains (6) summary
    COG5048
    Location:103180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132152
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:753773
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:145169
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:808831
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657737
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers
  28. XM_047439768.1XP_047295724.1  zinc finger protein 536 isoform X2

  29. XM_017027534.2XP_016883023.1  zinc finger protein 536 isoform X1

    Conserved Domains (6) summary
    COG5048
    Location:103180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132152
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:753773
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:145169
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:808831
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657737
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers
  30. XM_017027527.2XP_016883016.1  zinc finger protein 536 isoform X1

    Conserved Domains (6) summary
    COG5048
    Location:103180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132152
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:753773
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:145169
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:808831
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657737
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers
  31. XM_017027537.2XP_016883026.1  zinc finger protein 536 isoform X2

    Conserved Domains (6) summary
    COG5048
    Location:103180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:753773
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:753773
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:765787
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:779802
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657737
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers
  32. XM_017027528.2XP_016883017.1  zinc finger protein 536 isoform X1

    Conserved Domains (6) summary
    COG5048
    Location:103180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132152
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:753773
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:145169
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:808831
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657737
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers
  33. XM_017027536.2XP_016883025.1  zinc finger protein 536 isoform X1

    Conserved Domains (6) summary
    COG5048
    Location:103180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132152
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:753773
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:145169
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:808831
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657737
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers
  34. XM_011527558.3XP_011525860.1  zinc finger protein 536 isoform X1

    See identical proteins and their annotated locations for XP_011525860.1

    Conserved Domains (6) summary
    COG5048
    Location:103180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132152
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:753773
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:145169
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:808831
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657737
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers
  35. XM_047439771.1XP_047295727.1  zinc finger protein 536 isoform X2

  36. XM_047439782.1XP_047295738.1  zinc finger protein 536 isoform X5

    UniProtKB/Swiss-Prot
    A2RU18
  37. XM_017027539.2XP_016883028.1  zinc finger protein 536 isoform X3

    Conserved Domains (6) summary
    COG5048
    Location:103180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132152
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:753773
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:145169
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:808831
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657737
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers
  38. XM_017027542.2XP_016883031.1  zinc finger protein 536 isoform X5

    UniProtKB/Swiss-Prot
    A2RU18, O15090
    Conserved Domains (6) summary
    COG5048
    Location:103180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:753773
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:753773
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:765787
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:779802
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657737
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers
  39. XM_047439777.1XP_047295733.1  zinc finger protein 536 isoform X5

    UniProtKB/Swiss-Prot
    A2RU18
  40. XM_047439786.1XP_047295742.1  zinc finger protein 536 isoform X5

    UniProtKB/Swiss-Prot
    A2RU18
  41. XM_011527557.3XP_011525859.1  zinc finger protein 536 isoform X1

    See identical proteins and their annotated locations for XP_011525859.1

    Conserved Domains (6) summary
    COG5048
    Location:103180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132152
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:753773
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:145169
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:808831
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657737
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers
  42. XM_011527560.3XP_011525862.1  zinc finger protein 536 isoform X2

    Conserved Domains (6) summary
    COG5048
    Location:103180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:753773
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:753773
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:765787
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:779802
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657737
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers
  43. XM_017027543.3XP_016883032.1  zinc finger protein 536 isoform X6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    32746044..33234121
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)