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GPRASP1 G protein-coupled receptor associated sorting protein 1 [ Homo sapiens (human) ]

Gene ID: 9737, updated on 13-Mar-2020

Summary

Official Symbol
GPRASP1provided by HGNC
Official Full Name
G protein-coupled receptor associated sorting protein 1provided by HGNC
Primary source
HGNC:HGNC:24834
See related
Ensembl:ENSG00000198932 MIM:300417
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GASP; GASP1; GASP-1
Summary
This gene encodes a member of the GPRASP (G protein-coupled receptor associated sorting protein) family. The protein may modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. It targets receptors for degradation in lysosomes. The receptors interacting with this sorting protein include D2 dopamine receptor (DRD2), delta opioid receptor (OPRD1), beta-2 adrenergic receptor (ADRB2), D4 dopamine receptor (DRD4) and cannabinoid 1 receptor (CB1R). Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, May 2010]
Expression
Broad expression in brain (RPKM 27.6), ovary (RPKM 20.3) and 21 other tissues See more
Orthologs

Genomic context

See GPRASP1 in Genome Data Viewer
Location:
Xq22.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (102651366..102659083)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (101906294..101914011)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ARMCX5-GPRASP2 readthrough Neighboring gene armadillo repeat containing X-linked 5 Neighboring gene H3 histone pseudogene 45 Neighboring gene RNA, U6 small nuclear 589, pseudogene Neighboring gene BEN domain containing 7 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Readthrough ARMCX5-GPRASP2

Readthrough gene: ARMCX5-GPRASP2, Included gene: ARMCX5, Included gene: BHLHB9, Included gene: GPRASP2, Included gene: LINC00630

Homology

Clone Names

  • KIAA0443

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
G protein-coupled receptor catabolic process IPI
Inferred from Physical Interaction
more info
PubMed 
endosome to lysosome transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
G-protein coupled receptor-associated sorting protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021332.1 RefSeqGene

    Range
    5118..12718
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001099410.1NP_001092880.1  G-protein coupled receptor-associated sorting protein 1

    See identical proteins and their annotated locations for NP_001092880.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' UTR and encodes the same protein, as compared to variant 1.
    Source sequence(s)
    AW293629, AY044233, BC114552, BP193624, DA104338
    Consensus CDS
    CCDS35352.1
    UniProtKB/Swiss-Prot
    Q5JY77
    Related
    ENSP00000393691.1, ENST00000415986.5
    Conserved Domains (1) summary
    pfam04826
    Location:11671390
    Arm_2; Armadillo-like
  2. NM_001099411.1NP_001092881.1  G-protein coupled receptor-associated sorting protein 1

    See identical proteins and their annotated locations for NP_001092881.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two exons in the 5' UTR and encodes the same protein, as compared to variant 1.
    Source sequence(s)
    AW293629, AY044233, BC114552, BP193624, DA094297
    Consensus CDS
    CCDS35352.1
    UniProtKB/Swiss-Prot
    Q5JY77
    Related
    ENSP00000409420.1, ENST00000444152.5
    Conserved Domains (1) summary
    pfam04826
    Location:11671390
    Arm_2; Armadillo-like
  3. NM_001184727.2NP_001171656.1  G-protein coupled receptor-associated sorting protein 1

    See identical proteins and their annotated locations for NP_001171656.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has an additional exon in the 5' UTR and encodes the same protein, as compared to variant 1.
    Source sequence(s)
    AW293629, AY044233, BC114552, BX489726, BX954816
    Consensus CDS
    CCDS35352.1
    UniProtKB/Swiss-Prot
    Q5JY77
    Related
    ENSP00000445683.1, ENST00000537097.2
    Conserved Domains (1) summary
    pfam04826
    Location:11671390
    Arm_2; Armadillo-like
  4. NM_014710.5NP_055525.3  G-protein coupled receptor-associated sorting protein 1

    See identical proteins and their annotated locations for NP_055525.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents a dominant transcript. Variants 1-4 encode the same protein.
    Source sequence(s)
    AW293629, AY044233, BC114552, DA222893
    Consensus CDS
    CCDS35352.1
    UniProtKB/Swiss-Prot
    Q5JY77
    Related
    ENSP00000355146.4, ENST00000361600.9
    Conserved Domains (1) summary
    pfam04826
    Location:11671390
    Arm_2; Armadillo-like

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    102651366..102659083
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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