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GPRASP2 G protein-coupled receptor associated sorting protein 2 [ Homo sapiens (human) ]

Gene ID: 114928, updated on 3-Mar-2019

Summary

Official Symbol
GPRASP2provided by HGNC
Official Full Name
G protein-coupled receptor associated sorting protein 2provided by HGNC
Primary source
HGNC:HGNC:25169
See related
Ensembl:ENSG00000158301 MIM:300969
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DFNX7; GASP2
Summary
The protein encoded by this gene is a member of a family that regulates the activity of G protein-coupled receptors (GPCRs). The encoded protein has been shown to be capable of interacting with several GPCRs, including the M1 muscarinic acetylcholine receptor and the calcitonin receptor. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]
Expression
Broad expression in brain (RPKM 5.6), ovary (RPKM 5.0) and 24 other tissues See more
Orthologs

Genomic context

See GPRASP2 in Genome Data Viewer
Location:
Xq22.1
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (102712176..102717733)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (101967104..101972661)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ARMCX5-GPRASP2 readthrough Neighboring gene RNA, U6 small nuclear 589, pseudogene Neighboring gene BEN domain containing 7 pseudogene 1 Neighboring gene basic helix-loop-helix family member b9 Neighboring gene long intergenic non-protein coding RNA 630 Neighboring gene MT-ND1 pseudogene 32

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough ARMCX5-GPRASP2

Readthrough gene: ARMCX5-GPRASP2, Included gene: GPRASP1, Included gene: ARMCX5, Included gene: BHLHB9, Included gene: LINC00630

Homology

Clone Names

  • FLJ35662, FLJ37327

Gene Ontology Provided by GOA

Function Evidence Code Pubs
amyloid-beta binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
G-protein coupled receptor-associated sorting protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021322.1 RefSeqGene

    Range
    4848..10405
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001004051.3NP_001004051.1  G-protein coupled receptor-associated sorting protein 2

    See identical proteins and their annotated locations for NP_001004051.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. All five variants encode the same protein.
    Source sequence(s)
    AK123832, AL522674, BC051707
    Consensus CDS
    CCDS14501.1
    UniProtKB/Swiss-Prot
    Q96D09
    UniProtKB/TrEMBL
    B3KW05
    Conserved Domains (2) summary
    pfam04826
    Location:593837
    Arm_2; Armadillo-like
    cl26386
    Location:1163
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  2. NM_001184874.2NP_001171803.1  G-protein coupled receptor-associated sorting protein 2

    See identical proteins and their annotated locations for NP_001171803.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. All five variants encode the same protein.
    Source sequence(s)
    AK123832, BC051707, DA389655
    Consensus CDS
    CCDS14501.1
    UniProtKB/Swiss-Prot
    Q96D09
    UniProtKB/TrEMBL
    B3KW05
    Related
    ENSP00000437872.1, ENST00000543253.5
    Conserved Domains (2) summary
    pfam04826
    Location:593837
    Arm_2; Armadillo-like
    cl26386
    Location:1163
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  3. NM_001184875.2NP_001171804.1  G-protein coupled receptor-associated sorting protein 2

    See identical proteins and their annotated locations for NP_001171804.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. All five variants encode the same protein.
    Source sequence(s)
    AK123832, BC051707, DA231935
    Consensus CDS
    CCDS14501.1
    UniProtKB/Swiss-Prot
    Q96D09
    UniProtKB/TrEMBL
    B3KW05
    Related
    ENSP00000437394.1, ENST00000535209.5
    Conserved Domains (2) summary
    pfam04826
    Location:593837
    Arm_2; Armadillo-like
    cl26386
    Location:1163
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  4. NM_001184876.2NP_001171805.1  G-protein coupled receptor-associated sorting protein 2

    See identical proteins and their annotated locations for NP_001171805.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 3. All five variants encode the same protein.
    Source sequence(s)
    AK123832, BC051707, DA776293
    Consensus CDS
    CCDS14501.1
    UniProtKB/Swiss-Prot
    Q96D09
    UniProtKB/TrEMBL
    B3KW05
    Conserved Domains (2) summary
    pfam04826
    Location:593837
    Arm_2; Armadillo-like
    cl26386
    Location:1163
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  5. NM_138437.5NP_612446.1  G-protein coupled receptor-associated sorting protein 2

    See identical proteins and their annotated locations for NP_612446.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. All five variants encode the same protein.
    Source sequence(s)
    AK123832, BC051707
    Consensus CDS
    CCDS14501.1
    UniProtKB/Swiss-Prot
    Q96D09
    UniProtKB/TrEMBL
    B3KW05
    Related
    ENSP00000339057.3, ENST00000332262.9
    Conserved Domains (2) summary
    pfam04826
    Location:593837
    Arm_2; Armadillo-like
    cl26386
    Location:1163
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

    Range
    102712176..102717733
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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