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ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough [ Homo sapiens (human) ]

Gene ID: 100528062, updated on 5-Aug-2022

Summary

Official Symbol
ARMCX5-GPRASP2provided by HGNC
Official Full Name
ARMCX5-GPRASP2 readthroughprovided by HGNC
Primary source
HGNC:HGNC:42000
See related
Ensembl:ENSG00000286237 AllianceGenome:HGNC:42000
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
bHLHb9; p60TRP; ARMCX5-GPRASP2-BHLHB9-LINC00630
Summary
This locus represents naturally occurring readthrough transcription among the adjacent armadillo repeat containing, X-linked 5 (ARMCX5), G protein-coupled receptor associated sorting proteins 1 and 2 (GPRASP1 and GPRASP2), basic helix-loop-helix family member b9 (BHLHB9), and long intergenic non-protein coding RNA 630 (LINC00630) genes on chromosome X. Transcripts may make use of multiple alternative promoters and polyadenylation signals in this region. Readthrough transcripts may produce proteins identical to the proteins encoded by GPRASP2 or BHLHB9. [provided by RefSeq, Apr 2017]
Expression
Ubiquitous expression in brain (RPKM 5.9), ovary (RPKM 5.3) and 25 other tissues See more
Orthologs
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Genomic context

See ARMCX5-GPRASP2 in Genome Data Viewer
Location:
Xq22.1
Exon count:
32
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (102599348..102908064)
110 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (101044303..101353019)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (101854276..102162992)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene nuclear RNA export factor 5 pseudogene Neighboring gene forkhead box N3 pseudogene 1 Neighboring gene nuclear RNA export factor 4 pseudogene Neighboring gene armadillo repeat containing X-linked 5 Neighboring gene H3 histone pseudogene 45 Neighboring gene G protein-coupled receptor associated sorting protein 1 Neighboring gene RNA, U6 small nuclear 589, pseudogene Neighboring gene BEN domain containing 7 pseudogene 1 Neighboring gene G protein-coupled receptor associated sorting protein 2 Neighboring gene G protein-coupled receptor associated sorting protein family member 3 Neighboring gene long intergenic non-protein coding RNA 630 Neighboring gene MT-ND1 pseudogene 32 Neighboring gene MT-ATP6 pseudogene 19 Neighboring gene MT-ND2 pseudogene 2 Neighboring gene MT-CO1 pseudogene 19 Neighboring gene MT-CO2 pseudogene 19 Neighboring gene MT-CO3 pseudogene 19 Neighboring gene MT-ND4 pseudogene 32 Neighboring gene MT-ND5 pseudogene 26 Neighboring gene MT-ND6 pseudogene 32 Neighboring gene MT-CYB pseudogene 32 Neighboring gene RAB40A like Neighboring gene NUDT19 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ39373, KIAA1701

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables amyloid-beta binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in hematopoietic stem cell homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in learning or memory ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of dendritic spine morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of neurogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of synapse assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular exosome HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
G-protein coupled receptor-associated sorting protein 2; protein BHLHb9
Names
ARMCX5-GPRASP2-BHLHB9-LINC00630 readthrough
transcription regulator of 60 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199818.1NP_001186747.1  G-protein coupled receptor-associated sorting protein 2 isoform Gprasp2

    See identical proteins and their annotated locations for NP_001186747.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) incorporates exons from ARMCX5 and GPRASP2 and encodes the same protein as GPRASP2.
    Source sequence(s)
    AL035427, AL035551, BG392679
    UniProtKB/Swiss-Prot
    Q8NAB4, Q96D09
    Conserved Domains (2) summary
    pfam04826
    Location:593837
    Arm_2; Armadillo-like
    cl26386
    Location:1163
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  2. NM_001350268.2NP_001337197.1  protein BHLHb9 isoform Bhlhb9

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) incorporates exons from ARMCX5, GPRASP2, and BHLHB9 and encodes the same protein as BHLHB9.
    Source sequence(s)
    AL035427, AL035551
    UniProtKB/Swiss-Prot
    Q9C0G2
    Conserved Domains (1) summary
    pfam04826
    Location:314542
    Arm_2; Armadillo-like
  3. NM_001350269.2NP_001337198.1  protein BHLHb9 isoform Bhlhb9

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) incorporates exons from GPRASP2 and BHLHB9 and encodes the same protein as BHLHB9.
    Source sequence(s)
    AL035427
    UniProtKB/Swiss-Prot
    Q9C0G2
    Related
    ENSP00000498643.1, ENST00000652409.1
    Conserved Domains (1) summary
    pfam04826
    Location:314542
    Arm_2; Armadillo-like
  4. NM_001350270.1NP_001337199.1  protein BHLHb9 isoform Bhlhb9

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) incorporates exons from GPRASP2 and BHLHB9 and encodes the same protein as BHLHB9.
    Source sequence(s)
    AL035427
    UniProtKB/Swiss-Prot
    Q9C0G2
    Conserved Domains (1) summary
    pfam04826
    Location:314542
    Arm_2; Armadillo-like

RNA

  1. NR_146584.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) incorporates exons from ARMCX5, GPRASP2, BHLHB9, and LINC00630 and is unlikely to encode a protein.
    Source sequence(s)
    AL035427, AL035551, AL590407, FO393405, Z68871, Z95624
  2. NR_146585.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) incorporates exons from GPRASP2 and BHLHB9 and is unlikely to encodes a protein.
    Source sequence(s)
    AL035427
  3. NR_146586.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) incorporates exons from GPRASP2 and BHLHB9 and is unlikely to encode a protein.
    Source sequence(s)
    AL035427
  4. NR_146587.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) incorporates exons from GPRASP2, BHLHB9, and LINC00630 and is unlikely to encode a protein.
    Source sequence(s)
    AL035427, AL590407, Z68871

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    102599348..102908064
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    101044303..101353019
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)