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DHX34 DExH-box helicase 34 [ Homo sapiens (human) ]

Gene ID: 9704, updated on 21-Apr-2019

Summary

Official Symbol
DHX34provided by HGNC
Official Full Name
DExH-box helicase 34provided by HGNC
Primary source
HGNC:HGNC:16719
See related
Ensembl:ENSG00000134815 MIM:615475
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HRH1; DDX34
Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. It is mapped to the glioma 19q tumor suppressor region and is a tumor suppressor candidate gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 9.0), bone marrow (RPKM 4.3) and 25 other tissues See more
Orthologs

Genomic context

See DHX34 in Genome Data Viewer
Location:
19q13.32
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (47349281..47382704)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (47852538..47885961)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene complement C5a receptor 1 Neighboring gene complement component 5a receptor 2 Neighboring gene Meis homeobox 3 Neighboring gene solute carrier family 8 member A2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0134

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
Component Evidence Code Pubs
membrane HDA PubMed 

General protein information

Preferred Names
probable ATP-dependent RNA helicase DHX34
Names
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 34
DEAH (Asp-Glu-Ala-His) box polypeptide 34
DEAH box protein 34
DEAH-box helicase 34
probable ATP-dependent helicase DHX34
NP_055496.2
XP_005259500.1
XP_011525852.1
XP_011525853.1
XP_016883013.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014681.6NP_055496.2  probable ATP-dependent RNA helicase DHX34

    See identical proteins and their annotated locations for NP_055496.2

    Status: REVIEWED

    Source sequence(s)
    AK297692, BI826597, BU732557, CF125648, CN307402, DR762320
    Consensus CDS
    CCDS12700.1
    UniProtKB/Swiss-Prot
    Q14147
    Related
    ENSP00000331907.4, ENST00000328771.9
    Conserved Domains (5) summary
    smart00490
    Location:410496
    HELICc; helicase superfamily c-terminal domain
    smart00847
    Location:565645
    HA2; Helicase associated domain (HA2) Add an annotation
    COG1643
    Location:154686
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    cd00046
    Location:179314
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam07717
    Location:791911
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    47349281..47382704
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259443.3XP_005259500.1  probable ATP-dependent RNA helicase DHX34 isoform X1

    See identical proteins and their annotated locations for XP_005259500.1

    UniProtKB/Swiss-Prot
    Q14147
    Conserved Domains (5) summary
    smart00490
    Location:410496
    HELICc; helicase superfamily c-terminal domain
    smart00847
    Location:565645
    HA2; Helicase associated domain (HA2) Add an annotation
    COG1643
    Location:154686
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    cd00046
    Location:179314
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam07717
    Location:791911
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
  2. XM_017027524.1XP_016883013.1  probable ATP-dependent RNA helicase DHX34 isoform X2

    UniProtKB/Swiss-Prot
    Q14147
    Conserved Domains (2) summary
    smart00847
    Location:34114
    HA2; Helicase associated domain (HA2) Add an annotation
    pfam07717
    Location:260380
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
  3. XM_011527551.2XP_011525853.1  probable ATP-dependent RNA helicase DHX34 isoform X1

    See identical proteins and their annotated locations for XP_011525853.1

    UniProtKB/Swiss-Prot
    Q14147
    Conserved Domains (5) summary
    smart00490
    Location:410496
    HELICc; helicase superfamily c-terminal domain
    smart00847
    Location:565645
    HA2; Helicase associated domain (HA2) Add an annotation
    COG1643
    Location:154686
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    cd00046
    Location:179314
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam07717
    Location:791911
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
  4. XM_011527550.2XP_011525852.1  probable ATP-dependent RNA helicase DHX34 isoform X1

    See identical proteins and their annotated locations for XP_011525852.1

    UniProtKB/Swiss-Prot
    Q14147
    Conserved Domains (5) summary
    smart00490
    Location:410496
    HELICc; helicase superfamily c-terminal domain
    smart00847
    Location:565645
    HA2; Helicase associated domain (HA2) Add an annotation
    COG1643
    Location:154686
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    cd00046
    Location:179314
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam07717
    Location:791911
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

RNA

  1. XR_243974.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_194428.1: Suppressed sequence

    Description
    NM_194428.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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