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ZNF432 zinc finger protein 432 [ Homo sapiens (human) ]

Gene ID: 9668, updated on 6-Sep-2022

Summary

Official Symbol
ZNF432provided by HGNC
Official Full Name
zinc finger protein 432provided by HGNC
Primary source
HGNC:HGNC:20810
See related
Ensembl:ENSG00000256087 AllianceGenome:HGNC:20810
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in prostate (RPKM 5.4), testis (RPKM 3.4) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF432 in Genome Data Viewer
Location:
19q13.41
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (52031378..52048838, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (55118576..55136058, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (52534631..52552091, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904755 Neighboring gene zinc finger protein 614 Neighboring gene uncharacterized LOC112268244 Neighboring gene zinc finger protein 160 pseudogene Neighboring gene zinc finger protein 841 Neighboring gene zinc finger protein 616 Neighboring gene small nucleolar RNA U13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

EBI GWAS Catalog

Description
Inhaled corticosteroid treatment modulates ZNF432 gene variant's effect on bronchodilator response in asthmatics.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001322284.2NP_001309213.1  zinc finger protein 432

    Status: VALIDATED

    Source sequence(s)
    AB018341, AC011468, BC002858, DA993118
    Consensus CDS
    CCDS12848.1
    UniProtKB/Swiss-Prot
    O94892
    UniProtKB/TrEMBL
    A0A024R4I3
    Conserved Domains (5) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:259636
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:431451
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:527551
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001322285.1NP_001309214.1  zinc finger protein 432

    Status: VALIDATED

    Source sequence(s)
    AB018341, AC011468
    Consensus CDS
    CCDS12848.1
    UniProtKB/Swiss-Prot
    O94892
    UniProtKB/TrEMBL
    A0A024R4I3
    Related
    ENSP00000470488.1, ENST00000594154.5
    Conserved Domains (5) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:259636
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:431451
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:527551
    zf-H2C2_2; Zinc-finger double domain
  3. NM_014650.4NP_055465.1  zinc finger protein 432

    See identical proteins and their annotated locations for NP_055465.1

    Status: VALIDATED

    Source sequence(s)
    AB018341, AC011468, BC002858, DB079612
    Consensus CDS
    CCDS12848.1
    UniProtKB/Swiss-Prot
    O94892
    UniProtKB/TrEMBL
    A0A024R4I3
    Related
    ENSP00000221315.4, ENST00000221315.10
    Conserved Domains (5) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:259636
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:431451
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:527551
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    52031378..52048838 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451806.2XP_024307574.1  zinc finger protein 432 isoform X1

    Conserved Domains (2) summary
    COG5048
    Location:163540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:335355
    ZF_C2H2; C2H2 Zn finger [structural motif]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    55118576..55136058 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)