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IKBKE inhibitor of nuclear factor kappa B kinase subunit epsilon [ Homo sapiens (human) ]

Gene ID: 9641, updated on 13-Mar-2020

Summary

Official Symbol
IKBKEprovided by HGNC
Official Full Name
inhibitor of nuclear factor kappa B kinase subunit epsilonprovided by HGNC
Primary source
HGNC:HGNC:14552
See related
Ensembl:ENSG00000263528 MIM:605048
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IKKE; IKKI; IKK-E; IKK-i
Summary
IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009]
Expression
Broad expression in lymph node (RPKM 9.0), appendix (RPKM 7.5) and 20 other tissues See more
Orthologs

Genomic context

See IKBKE in Genome Data Viewer
Location:
1q32.1
Exon count:
22
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (206470243..206496890)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (206643586..206670223)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372873 Neighboring gene ribosomal protein L22 pseudogene 4 Neighboring gene family with sequence similarity 72 member A Neighboring gene SLIT-ROBO Rho GTPase activating protein 2 Neighboring gene microRNA 6769b Neighboring gene Ras association domain family member 5 Neighboring gene ribosomal protein L7a pseudogene 20 Neighboring gene eukaryotic translation initiation factor 2D

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120/CD4 interaction-induced NF-kappaB activation stimulates the hyperphosphorylation of IkappaB-alpha by IkappaB kinases (IKKs) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0151, MGC125294, MGC125295, MGC125297

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
IkappaB kinase activity IEA
Inferred from Electronic Annotation
more info
 
K48-linked polyubiquitin modification-dependent protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT K63-linked polyubiquitin modification-dependent protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
NF-kappaB-inducing kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity TAS
Traceable Author Statement
more info
 
protein phosphatase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
I-kappaB phosphorylation IEA
Inferred from Electronic Annotation
more info
 
NIK/NF-kappaB signaling IEA
Inferred from Electronic Annotation
more info
 
TRIF-dependent toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
cellular response to virus IEA
Inferred from Electronic Annotation
more info
 
immune response NAS
Non-traceable Author Statement
more info
PubMed 
intrinsic apoptotic signaling pathway in response to DNA damage IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of type I interferon production TAS
Traceable Author Statement
more info
 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IEP
Inferred from Expression Pattern
more info
PubMed 
positive regulation of lipid storage ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of type I interferon-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
response to interferon-beta IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to type I interferon IEA
Inferred from Electronic Annotation
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
PML body IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endosome membrane TAS
Traceable Author Statement
more info
 
mitochondrial membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
inhibitor of nuclear factor kappa-B kinase subunit epsilon
Names
I-kappa-B kinase epsilon
IKK-epsilon
IKK-related kinase epsilon
inducible I kappa-B kinase
inducible IkappaB kinase
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
NP_001180250.1
NP_001180251.1
NP_054721.1
XP_005273413.1
XP_016858357.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193321.2NP_001180250.1  inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 3

    See identical proteins and their annotated locations for NP_001180250.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate segment which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
    Source sequence(s)
    BC107812, CB243308, D63485, DA999897
    Consensus CDS
    CCDS53464.1
    UniProtKB/Swiss-Prot
    Q14164
    Related
    ENSP00000462396.1, ENST00000584998.5
    Conserved Domains (2) summary
    cd12219
    Location:212298
    UBL_TBK1_like; Ubiquitin-Like Domain Of Human Tbk1 and similar proteins
    cl21453
    Location:1245
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001193322.2NP_001180251.1  inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate segment in the 3' coding region, which shifts the reading frame, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus when it is compared to isoform 1.
    Source sequence(s)
    BC107591, CB243308, D63485, DA999897, DB152295
    Consensus CDS
    CCDS73019.1
    UniProtKB/Swiss-Prot
    Q14164
    UniProtKB/TrEMBL
    A0A075B7B4
    Related
    ENSP00000473833.1, ENST00000578328.6
    Conserved Domains (3) summary
    smart00220
    Location:9242
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd12219
    Location:297383
    UBL_TBK1_like; Ubiquitin-Like Domain Of Human Tbk1 and similar proteins
    cl21453
    Location:15330
    PKc_like; Protein Kinases, catalytic domain
  3. NM_014002.4NP_054721.1  inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 1

    See identical proteins and their annotated locations for NP_054721.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longest transcript and it encodes the longest protein (isoform 1).
    Source sequence(s)
    BC105923, CB243308, D63485, DA990116, DB152295
    Consensus CDS
    CCDS30996.1
    UniProtKB/Swiss-Prot
    Q14164
    Related
    ENSP00000464030.1, ENST00000581977.7
    Conserved Domains (2) summary
    cd12219
    Location:297383
    UBL_TBK1_like; Ubiquitin-Like Domain Of Human Tbk1 and similar proteins
    cl21453
    Location:15330
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    206470243..206496890
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005273356.2XP_005273413.1  inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1

    See identical proteins and their annotated locations for XP_005273413.1

    UniProtKB/Swiss-Prot
    Q14164
    Conserved Domains (2) summary
    cd12219
    Location:297383
    UBL_TBK1_like; Ubiquitin-Like Domain Of Human Tbk1 and similar proteins
    cl21453
    Location:15330
    PKc_like; Protein Kinases, catalytic domain
  2. XM_017002868.1XP_016858357.1  inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X2

RNA

  1. XR_922002.2 RNA Sequence

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