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IKBKE inhibitor of nuclear factor kappa B kinase subunit epsilon [ Homo sapiens (human) ]

Gene ID: 9641, updated on 26-Jan-2024

Summary

Official Symbol
IKBKEprovided by HGNC
Official Full Name
inhibitor of nuclear factor kappa B kinase subunit epsilonprovided by HGNC
Primary source
HGNC:HGNC:14552
See related
Ensembl:ENSG00000263528 MIM:605048; AllianceGenome:HGNC:14552
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IKKE; IKKI; IKK-E; IKK-i
Summary
IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009]
Expression
Broad expression in lymph node (RPKM 9.0), appendix (RPKM 7.5) and 20 other tissues See more
Orthologs
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Genomic context

See IKBKE in Genome Data Viewer
Location:
1q32.1
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (206470476..206496889)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (205734655..205761052)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (206643819..206670222)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372873 Neighboring gene ribosomal protein L22 pseudogene 4 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:206137267-206137987 Neighboring gene family with sequence similarity 72 member A Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr1:206105690-206106456 Neighboring gene SLIT-ROBO Rho GTPase activating protein 2 Neighboring gene Sharpr-MPRA regulatory region 15698 duplicate 3 Neighboring gene Sharpr-MPRA regulatory region 356 duplicate 3 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:206553913-206554820 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:206628023-206628694 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2398 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:206640325-206641190 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:206641191-206642054 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:206642729-206643366 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2400 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2401 Neighboring gene microRNA 6769b Neighboring gene uncharacterized LOC124904493 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2402 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2403 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1752 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1753 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1754 Neighboring gene IKBKE antisense RNA 1 Neighboring gene Ras association domain family member 5 Neighboring gene ribosomal protein L7a pseudogene 20

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120/CD4 interaction-induced NF-kappaB activation stimulates the hyperphosphorylation of IkappaB-alpha by IkappaB kinases (IKKs) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0151, MGC125294, MGC125295, MGC125297

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables IkappaB kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables K48-linked polyubiquitin modification-dependent protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT enables K63-linked polyubiquitin modification-dependent protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to virus IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response to virus NAS
Non-traceable Author Statement
more info
PubMed 
involved_in gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in immune response NAS
Non-traceable Author Statement
more info
PubMed 
involved_in interleukin-17-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA stabilization IEA
Inferred from Electronic Annotation
more info
 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in positive regulation of lipid storage ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of type I interferon production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of type I interferon-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of protein-containing complex assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in response to interferon-beta IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in type I interferon-mediated signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in PML body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in mitochondrial membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of serine/threonine protein kinase complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
inhibitor of nuclear factor kappa-B kinase subunit epsilon
Names
I-kappa-B kinase epsilon
IKK-epsilon
IKK-related kinase epsilon
inducible I kappa-B kinase
inducible IkappaB kinase
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
NP_001180250.1
NP_001180251.1
NP_054721.1
XP_005273413.1
XP_047290974.1
XP_047290976.1
XP_054195701.1
XP_054195702.1
XP_054195703.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193321.2NP_001180250.1  inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 3

    See identical proteins and their annotated locations for NP_001180250.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate segment which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
    Source sequence(s)
    BC107812, CB243308, D63485, DA999897
    Consensus CDS
    CCDS53464.1
    UniProtKB/Swiss-Prot
    Q14164
    Related
    ENSP00000462396.1, ENST00000584998.5
    Conserved Domains (2) summary
    cd12219
    Location:212298
    UBL_TBK1_like; Ubiquitin-Like Domain Of Human Tbk1 and similar proteins
    cl21453
    Location:1245
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001193322.2NP_001180251.1  inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate segment in the 3' coding region, which shifts the reading frame, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus when it is compared to isoform 1.
    Source sequence(s)
    BC107591, CB243308, D63485, DA999897, DB152295
    Consensus CDS
    CCDS73019.1
    UniProtKB/TrEMBL
    A0A075B7B4
    Related
    ENSP00000473833.1, ENST00000578328.6
    Conserved Domains (3) summary
    smart00220
    Location:9242
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd12219
    Location:297383
    UBL_TBK1_like; Ubiquitin-Like Domain Of Human Tbk1 and similar proteins
    cl21453
    Location:15330
    PKc_like; Protein Kinases, catalytic domain
  3. NM_014002.4NP_054721.1  inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 1

    See identical proteins and their annotated locations for NP_054721.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longest transcript and it encodes the longest protein (isoform 1).
    Source sequence(s)
    BC105923, CB243308, D63485, DA990116, DB152295
    Consensus CDS
    CCDS30996.1
    UniProtKB/Swiss-Prot
    D3DT78, Q14164, Q3B754, Q3KR43, Q5JTS6
    Related
    ENSP00000464030.1, ENST00000581977.7
    Conserved Domains (2) summary
    cd12219
    Location:297383
    UBL_TBK1_like; Ubiquitin-Like Domain Of Human Tbk1 and similar proteins
    cl21453
    Location:15330
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    206470476..206496889
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005273356.3XP_005273413.1  inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1

    See identical proteins and their annotated locations for XP_005273413.1

    UniProtKB/Swiss-Prot
    D3DT78, Q14164, Q3B754, Q3KR43, Q5JTS6
    Conserved Domains (2) summary
    cd12219
    Location:297383
    UBL_TBK1_like; Ubiquitin-Like Domain Of Human Tbk1 and similar proteins
    cl21453
    Location:15330
    PKc_like; Protein Kinases, catalytic domain
  2. XM_047435018.1XP_047290974.1  inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X2

  3. XM_047435020.1XP_047290976.1  inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    205734655..205761052
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054339726.1XP_054195701.1  inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1

  2. XM_054339727.1XP_054195702.1  inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X2

  3. XM_054339728.1XP_054195703.1  inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X3