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Ikbke inhibitor of kappaB kinase epsilon [ Mus musculus (house mouse) ]

Gene ID: 56489, updated on 18-Apr-2024

Summary

Official Symbol
Ikbkeprovided by MGI
Official Full Name
inhibitor of kappaB kinase epsilonprovided by MGI
Primary source
MGI:MGI:1929612
See related
Ensembl:ENSMUSG00000042349 AllianceGenome:MGI:1929612
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ikki; IKK-E; IKK-i; IKKepsilon
Summary
Enables IkappaB kinase activity; K48-linked polyubiquitin modification-dependent protein binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including interleukin-17-mediated signaling pathway; mRNA stabilization; and positive regulation of type I interferon-mediated signaling pathway. Predicted to be located in PML body and mitochondrial membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including future brain; sensory organ; submandibular gland primordium; thymus primordium; and turbinate bone primordium. Orthologous to human IKBKE (inhibitor of nuclear factor kappa B kinase subunit epsilon). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 20.8), large intestine adult (RPKM 16.0) and 18 other tissues See more
Orthologs
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Genomic context

Location:
1 E4; 1 56.93 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (131182337..131207339, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (131254600..131279601, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 2D Neighboring gene STARR-positive B cell enhancer ABC_E11692 Neighboring gene STARR-seq mESC enhancer starr_02214 Neighboring gene Ras association (RalGDS/AF-6) domain family member 5 Neighboring gene bystin-like pseudogene Neighboring gene predicted gene 28913 Neighboring gene STARR-positive B cell enhancer ABC_E10034 Neighboring gene predicted gene, 51644 Neighboring gene SLIT-ROBO Rho GTPase activating protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E5796 Neighboring gene STARR-positive B cell enhancer ABC_E5797 Neighboring gene predicted gene, 53252 Neighboring gene STARR-seq mESC enhancer starr_02218 Neighboring gene STARR-positive B cell enhancer ABC_E23 Neighboring gene STARR-positive B cell enhancer ABC_E8941 Neighboring gene family with sequence similarity 72, member A

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables IkappaB kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables K48-linked polyubiquitin modification-dependent protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables K48-linked polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to virus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in interleukin-17-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
involved_in mRNA stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of lipid storage IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of type I interferon production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of type I interferon-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of protein-containing complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to interferon-beta ISO
Inferred from Sequence Orthology
more info
 
involved_in response to type I interferon IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in PML body ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
inhibitor of nuclear factor kappa-B kinase subunit epsilon
Names
I-kappa-B kinase epsilon
IKK-epsilon
inducible I kappa-B kinase
inducible IKappaB kinase
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
NP_062751.2
XP_006529826.1
XP_006529827.1
XP_011246354.1
XP_017177332.1
XP_036008385.1
XP_036008388.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019777.3NP_062751.2  inhibitor of nuclear factor kappa-B kinase subunit epsilon

    See identical proteins and their annotated locations for NP_062751.2

    Status: VALIDATED

    Source sequence(s)
    AK088580
    Consensus CDS
    CCDS15269.1
    UniProtKB/Swiss-Prot
    Q8C2I3, Q9R0T8
    UniProtKB/TrEMBL
    Q3U6P9
    Related
    ENSMUSP00000054126.4, ENSMUST00000062108.10
    Conserved Domains (3) summary
    cd17128
    Location:308383
    Ubl_IKKE; ubiquitin-like (Ubl) domain found in inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKK-E)
    pfam18394
    Location:402648
    TBK1_CCD1; TANK-binding kinase 1 coiled-coil domain 1
    cl21453
    Location:15330
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    131182337..131207339 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248052.4XP_011246354.1  inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1

    See identical proteins and their annotated locations for XP_011246354.1

    UniProtKB/Swiss-Prot
    Q8C2I3, Q9R0T8
    UniProtKB/TrEMBL
    Q3U6P9
    Related
    ENSMUSP00000124190.2, ENSMUST00000161764.8
    Conserved Domains (3) summary
    cd17128
    Location:308383
    Ubl_IKKE; ubiquitin-like (Ubl) domain found in inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKK-E)
    pfam18394
    Location:402648
    TBK1_CCD1; TANK-binding kinase 1 coiled-coil domain 1
    cl21453
    Location:15330
    PKc_like; Protein Kinases, catalytic domain
  2. XM_036152492.1XP_036008385.1  inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X2

    Conserved Domains (3) summary
    cd17128
    Location:308383
    Ubl_IKKE; ubiquitin-like (Ubl) domain found in inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKK-E)
    pfam18394
    Location:402568
    TBK1_CCD1; TANK-binding kinase 1 coiled-coil domain 1
    cl21453
    Location:15330
    PKc_like; Protein Kinases, catalytic domain
  3. XM_006529764.4XP_006529827.1  inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X5

    Conserved Domains (3) summary
    cd17128
    Location:308383
    Ubl_IKKE; ubiquitin-like (Ubl) domain found in inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKK-E)
    pfam18394
    Location:402479
    TBK1_CCD1; TANK-binding kinase 1 coiled-coil domain 1
    cl21453
    Location:15330
    PKc_like; Protein Kinases, catalytic domain
  4. XM_006529763.4XP_006529826.1  inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X4

    Conserved Domains (3) summary
    cd17128
    Location:308383
    Ubl_IKKE; ubiquitin-like (Ubl) domain found in inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKK-E)
    pfam18394
    Location:402479
    TBK1_CCD1; TANK-binding kinase 1 coiled-coil domain 1
    cl21453
    Location:15330
    PKc_like; Protein Kinases, catalytic domain
  5. XM_017321843.2XP_017177332.1  inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X3

    Conserved Domains (3) summary
    cd17128
    Location:308383
    Ubl_IKKE; ubiquitin-like (Ubl) domain found in inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKK-E)
    pfam18394
    Location:402479
    TBK1_CCD1; TANK-binding kinase 1 coiled-coil domain 1
    cl21453
    Location:15330
    PKc_like; Protein Kinases, catalytic domain
  6. XM_036152495.1XP_036008388.1  inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X6

    Conserved Domains (2) summary
    cd17128
    Location:308383
    Ubl_IKKE; ubiquitin-like (Ubl) domain found in inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKK-E)
    cl21453
    Location:15330
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_387186.4 RNA Sequence