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ROCK2 Rho associated coiled-coil containing protein kinase 2 [ Homo sapiens (human) ]

Gene ID: 9475, updated on 17-May-2020

Summary

Official Symbol
ROCK2provided by HGNC
Official Full Name
Rho associated coiled-coil containing protein kinase 2provided by HGNC
Primary source
HGNC:HGNC:10252
See related
Ensembl:ENSG00000134318 MIM:604002
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ROCK-II
Summary
The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in fat (RPKM 15.2), colon (RPKM 13.4) and 25 other tissues See more
Orthologs

Genomic context

See ROCK2 in Genome Data Viewer
Location:
2p25.1
Exon count:
37
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (11179759..11345437, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (11319894..11484711, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC285150 Neighboring gene ribosomal protein L6 pseudogene 4 Neighboring gene chromosome 2 open reading frame 50 Neighboring gene solute carrier family 66 member 3 Neighboring gene RNA, U6 small nuclear 1081, pseudogene Neighboring gene AIDA pseudogene 1 Neighboring gene peptidylprolyl isomerase A pseudogene 60 Neighboring gene long intergenic non-protein coding RNA 570

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Filamin-A-dependent activation of the RhoA-ROCK-LIMK-cofilin pathway is a major event in HIV-1 gp120-induced receptor clustering PubMed
matrix gag HIV-1 p17-mediated activation of the Rho/ROCK-signaling pathway is required for p17-mediated monocyte adhesion and migration PubMed
gag HIV-1 p17-induced activation of PTEN is regulated by RhoA-associated kinase (ROCK) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0619

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
GTP-Rho binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA binding HDA PubMed 
Rho-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Rho-dependent protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Rho-dependent protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein serine/threonine kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
structural molecule activity NAS
Non-traceable Author Statement
more info
PubMed 
tau protein binding NAS
Non-traceable Author Statement
more info
PubMed 
tau-protein kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actomyosin structure organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
aortic valve morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to acetylcholine ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to testosterone stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
centrosome duplication IMP
Inferred from Mutant Phenotype
more info
PubMed 
cortical actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cortical actin cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
PubMed 
cortical actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ephrin receptor signaling pathway TAS
Traceable Author Statement
more info
 
mRNA destabilization ISS
Inferred from Sequence or Structural Similarity
more info
 
mitotic cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of bicellular tight junction assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of biomineral tissue development ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of myosin-light-chain-phosphatase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of myosin-light-chain-phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of nitric oxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of nitric oxide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of protein localization to lysosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-serine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-threonine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-threonine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of amyloid precursor protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of amyloid precursor protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of amyloid-beta formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of amyloid-beta formation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of cardiac muscle hypertrophy ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of centrosome duplication IEA
Inferred from Electronic Annotation
more info
 
positive regulation of connective tissue growth factor production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of connective tissue replacement ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of fibroblast growth factor production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein localization to early endosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to plasma membrane IGI
Inferred from Genetic Interaction
more info
PubMed 
protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of actin cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
regulation of angiotensin-activated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of blood vessel diameter ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell adhesion TAS
Traceable Author Statement
more info
PubMed 
regulation of cell junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell motility TAS
Traceable Author Statement
more info
PubMed 
regulation of cellular response to hypoxia ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of establishment of cell polarity TAS
Traceable Author Statement
more info
PubMed 
regulation of establishment of endothelial barrier IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of establishment of endothelial barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of focal adhesion assembly TAS
Traceable Author Statement
more info
PubMed 
regulation of keratinocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of neurological system process ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of protein metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of stress fiber assembly TAS
Traceable Author Statement
more info
PubMed 
response to angiotensin ISS
Inferred from Sequence or Structural Similarity
more info
 
response to ischemia ISS
Inferred from Sequence or Structural Similarity
more info
 
response to transforming growth factor beta ISS
Inferred from Sequence or Structural Similarity
more info
 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
smooth muscle contraction TAS
Traceable Author Statement
more info
PubMed 
vascular endothelial growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
viral RNA genome replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasmic ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
rho-associated protein kinase 2
Names
p164 ROCK-2
rho-associated, coiled-coil-containing protein kinase II
NP_001308572.1
NP_004841.2
XP_005246247.1
XP_011508719.1
XP_016860867.1
XP_016860868.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029769.1 RefSeqGene

    Range
    4950..169827
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001321643.2NP_001308572.1  rho-associated protein kinase 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AB014519, AC018463, AC099344, AL049383, BC111801
    UniProtKB/Swiss-Prot
    O75116
    UniProtKB/TrEMBL
    Q14DU5
    Related
    ENSP00000385509.1, ENST00000401753.5
    Conserved Domains (7) summary
    cd11638
    Location:419485
    HR1_ROCK2; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 2
    smart00220
    Location:6268
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1196
    Location:3501015
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:11751221
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01242
    Location:10651171
    PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
    cd05596
    Location:1330
    STKc_ROCK; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase
    pfam08912
    Location:893960
    Rho_Binding; Rho Binding
  2. NM_004850.5NP_004841.2  rho-associated protein kinase 2 isoform 1

    See identical proteins and their annotated locations for NP_004841.2

    Status: REVIEWED

    Source sequence(s)
    AB014519, AC018463, AC099344, AL049383, BC111801
    Consensus CDS
    CCDS42654.1
    UniProtKB/Swiss-Prot
    O75116
    UniProtKB/TrEMBL
    Q14DU5
    Related
    ENSP00000317985.6, ENST00000315872.11
    Conserved Domains (5) summary
    cd11638
    Location:505571
    HR1_ROCK2; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 2
    cd00029
    Location:12611307
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01242
    Location:11511257
    PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
    cd05621
    Location:39417
    STKc_ROCK2; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 2
    cl25732
    Location:4361101
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    11179759..11345437 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005246190.3XP_005246247.1  rho-associated protein kinase 2 isoform X1

    Conserved Domains (7) summary
    pfam05483
    Location:4121080
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    cd11638
    Location:505571
    HR1_ROCK2; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 2
    smart00220
    Location:92354
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00029
    Location:12611307
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01242
    Location:11511257
    PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
    cd05621
    Location:39417
    STKc_ROCK2; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 2
    pfam08912
    Location:9791046
    Rho_Binding; Rho Binding
  2. XM_017005379.2XP_016860868.1  rho-associated protein kinase 2 isoform X3

    Conserved Domains (7) summary
    cd11638
    Location:419485
    HR1_ROCK2; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 2
    smart00220
    Location:6268
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1196
    Location:3501015
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:11751221
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01242
    Location:10651171
    PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
    cd05596
    Location:1330
    STKc_ROCK; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase
    pfam08912
    Location:893960
    Rho_Binding; Rho Binding
  3. XM_011510417.2XP_011508719.1  rho-associated protein kinase 2 isoform X3

    Conserved Domains (7) summary
    cd11638
    Location:419485
    HR1_ROCK2; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 2
    smart00220
    Location:6268
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1196
    Location:3501015
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:11751221
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01242
    Location:10651171
    PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
    cd05596
    Location:1330
    STKc_ROCK; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase
    pfam08912
    Location:893960
    Rho_Binding; Rho Binding
  4. XM_017005378.2XP_016860867.1  rho-associated protein kinase 2 isoform X2

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