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Rock2 Rho-associated coiled-coil containing protein kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 19878, updated on 8-Dec-2022

Summary

Official Symbol
Rock2provided by MGI
Official Full Name
Rho-associated coiled-coil containing protein kinase 2provided by MGI
Primary source
MGI:MGI:107926
See related
Ensembl:ENSMUSG00000020580 AllianceGenome:MGI:107926
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rock2m; Rock-II; ROKalpha; mKIAA0619; Rho-kinase; B230113H15Rik
Summary
Enables protein serine/threonine kinase activity. Involved in several processes, including positive regulation of macromolecule metabolic process; protein phosphorylation; and regulation of signal transduction. Acts upstream of or within several processes, including extrinsic apoptotic signaling pathway via death domain receptors; nervous system development; and positive regulation of centrosome duplication. Located in Schaffer collateral - CA1 synapse; glutamatergic synapse; and spindle pole centrosome. Is expressed in several structures, including central nervous system; genitourinary system; heart; musculature; and somite. Orthologous to human ROCK2 (Rho associated coiled-coil containing protein kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 16.5), cortex adult (RPKM 10.8) and 25 other tissues See more
Orthologs
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Genomic context

See Rock2 in Genome Data Viewer
Location:
12; 12 A1.1
Exon count:
37
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (16944808..17038275)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (16894978..16988274)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene E2F transcription factor 6 Neighboring gene predicted gene, 36495 Neighboring gene predicted gene, 22303 Neighboring gene RIKEN cDNA 2410004P03 gene Neighboring gene solute carrier family 66 member 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables Rho-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables Rho-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within actin cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in actin cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in actomyosin structure organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in blood vessel diameter maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to acetylcholine IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to testosterone stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of centrosome duplication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in centrosome duplication ISO
Inferred from Sequence Orthology
more info
 
involved_in cortical actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cortical actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within dendrite morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in embryonic morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in epithelial to mesenchymal transition IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in mRNA destabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in modulation by host of viral process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of bicellular tight junction assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of myosin-light-chain-phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of nitric oxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein localization to lysosome ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neural tube closure IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-threonine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of amyloid precursor protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of amyloid precursor protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of amyloid-beta formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of amyloid-beta formation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cardiac muscle hypertrophy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cardiac muscle hypertrophy ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of centrosome duplication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of connective tissue growth factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of connective tissue replacement IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of connective tissue replacement ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fibroblast growth factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to early endosome ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in postsynaptic actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in postsynaptic actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of angiotensin-activated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cellular response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of establishment of endothelial barrier ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of keratinocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of nervous system process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synapse maturation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of synapse maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to angiotensin IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to ischemia IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to transforming growth factor beta IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to transforming growth factor beta ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasmic ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in spindle pole centrosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
rho-associated protein kinase 2
Names
Rho-associated coiled-coil forming kinage 2
p164 ROCK-2
rho-associated, coiled-coil-containing protein kinase 2
rho-associated, coiled-coil-containing protein kinase II
NP_033098.2
XP_036013163.1
XP_036013164.1
XP_036013165.1
XP_036013166.1
XP_036013167.1
XP_036013168.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009072.2NP_033098.2  rho-associated protein kinase 2

    See identical proteins and their annotated locations for NP_033098.2

    Status: VALIDATED

    Source sequence(s)
    AK045517, AK048955, AK153280, AK163082, CJ127012, CN536850, U58513
    Consensus CDS
    CCDS36410.1
    UniProtKB/Swiss-Prot
    P70336
    UniProtKB/TrEMBL
    F8VPK5, Q3TR46
    Related
    ENSMUSP00000020904.7, ENSMUST00000020904.8
    Conserved Domains (7) summary
    cd11638
    Location:505571
    HR1_ROCK2; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 2
    smart00220
    Location:92354
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1196
    Location:4371101
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:12611307
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01242
    Location:11511257
    PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
    cd05621
    Location:39417
    STKc_ROCK2; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 2
    pfam08912
    Location:9791046
    Rho_Binding; Rho Binding

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    16944808..17038275
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157270.1XP_036013163.1  rho-associated protein kinase 2 isoform X1

    Conserved Domains (5) summary
    COG1196
    Location:4371101
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01242
    Location:12081314
    PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
    cd05621
    Location:39417
    STKc_ROCK2; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 2
    cd22250
    Location:856936
    ROCK_SBD; Shroom-binding domain found in Rho-associated coiled-coil containing protein kinase
    cd20875
    Location:13071377
    C1_ROCK2; protein kinase C conserved region 1 (C1 domain) found in Rho-associated coiled-coil containing protein kinase 2 (ROCK2) and similar proteins
  2. XM_036157271.1XP_036013164.1  rho-associated protein kinase 2 isoform X2

    Related
    ENSMUSP00000152813.2, ENSMUST00000220688.2
    Conserved Domains (5) summary
    COG1196
    Location:4371101
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01242
    Location:12081314
    PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
    cd05621
    Location:39417
    STKc_ROCK2; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 2
    cd22250
    Location:856936
    ROCK_SBD; Shroom-binding domain found in Rho-associated coiled-coil containing protein kinase
    cd20875
    Location:13071377
    C1_ROCK2; protein kinase C conserved region 1 (C1 domain) found in Rho-associated coiled-coil containing protein kinase 2 (ROCK2) and similar proteins
  3. XM_036157272.1XP_036013165.1  rho-associated protein kinase 2 isoform X3

    Conserved Domains (5) summary
    COG1196
    Location:4371101
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01242
    Location:11511257
    PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
    cd05621
    Location:39417
    STKc_ROCK2; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 2
    cd22250
    Location:856936
    ROCK_SBD; Shroom-binding domain found in Rho-associated coiled-coil containing protein kinase
    cd20875
    Location:12501320
    C1_ROCK2; protein kinase C conserved region 1 (C1 domain) found in Rho-associated coiled-coil containing protein kinase 2 (ROCK2) and similar proteins
  4. XM_036157273.1XP_036013166.1  rho-associated protein kinase 2 isoform X4

    Conserved Domains (5) summary
    COG1196
    Location:318982
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01242
    Location:10891195
    PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
    cd05596
    Location:1296
    STKc_ROCK; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase
    cd22250
    Location:737817
    ROCK_SBD; Shroom-binding domain found in Rho-associated coiled-coil containing protein kinase
    cd20875
    Location:11881258
    C1_ROCK2; protein kinase C conserved region 1 (C1 domain) found in Rho-associated coiled-coil containing protein kinase 2 (ROCK2) and similar proteins
  5. XM_036157274.1XP_036013167.1  rho-associated protein kinase 2 isoform X4

    Conserved Domains (5) summary
    COG1196
    Location:318982
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01242
    Location:10891195
    PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
    cd05596
    Location:1296
    STKc_ROCK; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase
    cd22250
    Location:737817
    ROCK_SBD; Shroom-binding domain found in Rho-associated coiled-coil containing protein kinase
    cd20875
    Location:11881258
    C1_ROCK2; protein kinase C conserved region 1 (C1 domain) found in Rho-associated coiled-coil containing protein kinase 2 (ROCK2) and similar proteins
  6. XM_036157275.1XP_036013168.1  rho-associated protein kinase 2 isoform X4

    Conserved Domains (5) summary
    COG1196
    Location:318982
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01242
    Location:10891195
    PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
    cd05596
    Location:1296
    STKc_ROCK; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase
    cd22250
    Location:737817
    ROCK_SBD; Shroom-binding domain found in Rho-associated coiled-coil containing protein kinase
    cd20875
    Location:11881258
    C1_ROCK2; protein kinase C conserved region 1 (C1 domain) found in Rho-associated coiled-coil containing protein kinase 2 (ROCK2) and similar proteins