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CD86 CD86 molecule [ Homo sapiens (human) ]

Gene ID: 942, updated on 3-Oct-2021

Summary

Official Symbol
CD86provided by HGNC
Official Full Name
CD86 moleculeprovided by HGNC
Primary source
HGNC:HGNC:1705
See related
Ensembl:ENSG00000114013 MIM:601020
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B70; B7-2; B7.2; LAB72; CD28LG2
Summary
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]
Expression
Broad expression in appendix (RPKM 16.6), lymph node (RPKM 11.0) and 16 other tissues See more
Orthologs
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Genomic context

See CD86 in Genome Data Viewer
Location:
3q13.33
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (122055362..122121136)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (121774209..121839983)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927010 Neighboring gene Sharpr-MPRA regulatory region 6303 Neighboring gene immunoglobulin like domain containing receptor 1 Neighboring gene calcium sensing receptor Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 23

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
GeneReviews: Not available
Genome-wide Association Study Identifies Five Susceptibility Loci for Follicular Lymphoma outside the HLA Region.
GeneReviews: Not available
Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma.
GeneReviews: Not available
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The low mannose-level gp120 induces higher activation of plasmacytoid dendritic cells by upregulation of IFN-alpha, PD-L1, CD40, CCR7, CD80, and CD86 than the high mannose-level gp120 does PubMed
env HIV-1 gp120 downregulates the expression of CD86 in human B cells PubMed
env The presence of HIV-1 gp120 inhibits the oral mucosal pathogen Porphyromonas gingivalis-induced CD80, CD83, and CD86 upregulation PubMed
Nef nef HIV-1 Nef downregulates CD86 from the cell surface in the human monocytic U937 cell line as well as in mouse macrophages and dendritic cells PubMed
nef HIV-1 Nef co-localizes with MHC class I (MHCI), CD80, and CD86 in intracellular compartments by staining assays, and binds to both human CD80 and CD86 using yeast two-hybrid assays PubMed
nef HIV-1 Nef binds to the cytosolic tails of CD80 and CD86 to mediate their internalization PubMed
nef Activation and translocation of Src kinase is critical for Nef-mediated CD80 and CD86 internalization PubMed
nef HIV-1 Nef relocates cell-surface MHC-I, CD80, and CD86 to intracellular compartments and the Nef-mediated internalization is dependent on mediators of actin polymerization PubMed
Pr55(Gag) gag Expression of CD80, CD83, CD86, and HLA-DR molecules are significantly downregulated in mature dendritic cells after transduction with ubiquitinated Gag compared to unubiquitinated Gag constructs PubMed
gag HIV-1 Gag virus-like particles efficiently activate human monocyte-derived dendritic cells (MDDC) and induce MDDC maturation with an associated increase in the surface expression of CD80, CD86 and MHC classes I and II PubMed
gag HIV-1 Gag virus-like particle-induced monocyte activation is shown by upregulation of molecules involved in antigen presentation (MHC II, CD80, CD86) and cell adhesion (CD54) PubMed
Tat tat HIV-1 Tat upregulates the expression of MHC and co-stimulatory molecules CD40, CD80, CD83 and CD86 in monocyte-derived dendritic cells, thereby driving T cell-mediated immune responses PubMed
Vpr vpr HIV-1 Vpr inhibits the expression of co-stimulatory molecules including CD80, CD83, and CD86 at the transcriptional level without altering normal cellular transcription during dendritic cell maturation PubMed
vpr HIV-1 Vpr downregulates the expression of several immunologically important molecules including CD40, CD80, CD83, and CD86 co-stimulatory molecules on monocyte-derived macrophage (MDM) and monocyte-derived dendritic cells (MDDC) PubMed
capsid gag The immobilization of HIV-1 p24 antigen on the micelles upregulates the expression of cell surface markers CD80 and CD86 in human dendritic cells PubMed
matrix gag Treatment of human PBMCs with HIV-1 MA upregulates the expression of MCP-1, ICAM-1, CD40, CD86 and CD36 and downregulates the expression of nuclear receptors FXR and PPARgamma PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC34413

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables coreceptor activity NAS
Non-traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables virus receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in B cell activation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in CD40 signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in T cell costimulation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in activation of phospholipase C activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in activation of protein kinase C activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of T cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of NIK/NF-kappaB signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of T cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of T-helper 2 cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of cell population proliferation TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of immunoglobulin production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of interleukin-2 production NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of interleukin-4 production NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of lymphotoxin A production NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
involved_in viral entry into host cell IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
T-lymphocyte activation antigen CD86
Names
B-lymphocyte activation antigen B7-2
BU63
CD86 antigen (CD28 antigen ligand 2, B7-2 antigen)
CTLA-4 counter-receptor B7.2
FUN-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029928.1 RefSeqGene

    Range
    5001..70780
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001206924.2NP_001193853.2  T-lymphocyte activation antigen CD86 isoform 4 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC068630
    Consensus CDS
    CCDS56272.1
    Related
    ENSP00000420230.1, ENST00000493101.5
    Conserved Domains (2) summary
    cd00096
    Location:2733
    Ig; Ig strand A [structural motif]
    cl11960
    Location:24109
    Ig; Immunoglobulin domain
  2. NM_001206925.2NP_001193854.2  T-lymphocyte activation antigen CD86 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (5) is made from a downstream translation start site compared to isoform 1.
    Source sequence(s)
    AC068630
    Consensus CDS
    CCDS56273.1
    Related
    ENSP00000418988.1, ENST00000469710.5
    Conserved Domains (2) summary
    cd00096
    Location:37
    Ig; Ig strand D [structural motif]
    cl11960
    Location:151
    Ig; Immunoglobulin domain
  3. NM_006889.5NP_008820.4  T-lymphocyte activation antigen CD86 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an alternate exon in the 5' UTR, resulting in the use of a downstream start codon compared to variant 1. Isoform 2 has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC068630
    Consensus CDS
    CCDS43138.1
    Related
    ENSP00000377248.2, ENST00000393627.6
    Conserved Domains (3) summary
    cd00096
    Location:133139
    Ig; Ig strand A [structural motif]
    cd16087
    Location:20127
    IgV_CD86; Immunoglobulin variable domain (IgV) in Cluster of Differentiation (CD) 86
    cl11960
    Location:130215
    Ig; Immunoglobulin domain
  4. NM_175862.5NP_787058.5  T-lymphocyte activation antigen CD86 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1) of this protein.
    Source sequence(s)
    AC068630
    Consensus CDS
    CCDS3009.1
    Related
    ENSP00000332049.2, ENST00000330540.7
    Conserved Domains (2) summary
    cd16087
    Location:28133
    IgV_CD86; Immunoglobulin variable domain (IgV) in CD86
    cl11960
    Location:136221
    Ig; Immunoglobulin domain
  5. NM_176892.2NP_795711.2  T-lymphocyte activation antigen CD86 isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) includes an alternate exon in the 5' UTR, resulting in the use of a downstream start codon compared to variant 1. It also lacks an in-frame exon compared to variant 1. The resulting isoform (3, also known as CD86deltaTM) has a shorter N-terminus and lacks an internal segment compared to isoform 1. This isoform is the soluble form of this protein.
    Source sequence(s)
    AC068630
    Consensus CDS
    CCDS74991.1
    Related
    ENSP00000264468.6, ENST00000264468.9
    Conserved Domains (3) summary
    cd00096
    Location:133139
    Ig; Ig strand A [structural motif]
    cd16087
    Location:20127
    IgV_CD86; Immunoglobulin variable domain (IgV) in Cluster of Differentiation (CD) 86
    cl11960
    Location:130215
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    122055362..122121136
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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