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Cd86 CD86 antigen [ Mus musculus (house mouse) ]

Gene ID: 12524, updated on 16-Oct-2021

Summary

Official Symbol
Cd86provided by MGI
Official Full Name
CD86 antigenprovided by MGI
Primary source
MGI:MGI:101773
See related
Ensembl:ENSMUSG00000022901
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B7; B70; MB7; B7-2; B7.2; CLS1; Ly58; ETC-1; Ly-58; MB7-2; Cd28l2; TS/A-2
Expression
Broad expression in spleen adult (RPKM 3.3), liver E18 (RPKM 2.8) and 21 other tissues See more
Orthologs
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Genomic context

See Cd86 in Genome Data Viewer
Location:
16 B3; 16 25.72 cM
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (36389318..36486439, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (36568956..36666158, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (36603955..36666163, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene stefin A3 Neighboring gene calcium-sensing receptor Neighboring gene predicted gene, 49663 Neighboring gene predicted gene, 41451 Neighboring gene immunoglobulin-like domain containing receptor 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within B cell activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in B cell activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in CD40 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in T cell costimulation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in activation of phospholipase C activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in activation of protein kinase C activity IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within defense response to virus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of T cell anergy ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of T cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of NIK/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of T cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of T cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of activated T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of immunoglobulin production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in toll-like receptor 3 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within toll-like receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
T-lymphocyte activation antigen CD86
Names
activation B7-2 antigen
early T cell costimulatory molecule-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019388.3NP_062261.3  T-lymphocyte activation antigen CD86 precursor

    See identical proteins and their annotated locations for NP_062261.3

    Status: VALIDATED

    Source sequence(s)
    AK079513
    Consensus CDS
    CCDS28155.1
    UniProtKB/Swiss-Prot
    P42082
    UniProtKB/TrEMBL
    Q549Q9
    Related
    ENSMUSP00000087047.5, ENSMUST00000089620.11
    Conserved Domains (1) summary
    cd16087
    Location:28133
    IgV_CD86; Immunoglobulin variable domain (IgV) in CD86

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    36389318..36486439 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521741.1XP_006521804.1  T-lymphocyte activation antigen CD86 isoform X1

    See identical proteins and their annotated locations for XP_006521804.1

    UniProtKB/TrEMBL
    Q61238
    Conserved Domains (1) summary
    cd16087
    Location:33138
    IgV_CD86; Immunoglobulin variable domain (IgV) in CD86
  2. XM_011245812.3XP_011244114.1  T-lymphocyte activation antigen CD86 isoform X2

    See identical proteins and their annotated locations for XP_011244114.1

    UniProtKB/Swiss-Prot
    P42082
    Conserved Domains (1) summary
    cd16087
    Location:22127
    IgV_CD86; Immunoglobulin variable domain (IgV) in CD86

RNA

  1. XR_384517.1 RNA Sequence

  2. XR_004939150.1 RNA Sequence

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