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Zkscan8 zinc finger with KRAB and SCAN domains 8 [ Mus musculus (house mouse) ]

Gene ID: 93681, updated on 5-Mar-2024

Summary

Official Symbol
Zkscan8provided by MGI
Official Full Name
zinc finger with KRAB and SCAN domains 8provided by MGI
Primary source
MGI:MGI:1913815
See related
Ensembl:ENSMUSG00000063894 AllianceGenome:MGI:1913815
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LD5-1; Zfp192; 2510038J07Rik; D430019P06Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in early conceptus; eye; and genitourinary system. Orthologous to human ZKSCAN8 (zinc finger with KRAB and SCAN domains 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 5.0), whole brain E14.5 (RPKM 3.6) and 27 other tissues See more
Orthologs
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Genomic context

See Zkscan8 in Genome Data Viewer
Location:
13 A3.1; 13 7.84 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (21697391..21715284, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (21513221..21531114, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit 5B, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5373 Neighboring gene zinc finger protein 389 Neighboring gene predicted gene, 32724 Neighboring gene olfactory receptor family 1 subfamily F member 12 Neighboring gene olfactory receptor family 2 subfamily B member 7

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General protein information

Preferred Names
zinc finger protein with KRAB and SCAN domains 8
Names
zinc finger protein 192

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001251833.1NP_001238762.1  zinc finger protein with KRAB and SCAN domains 8 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two consecutive exons in the CDS, compared to variant 1. The reading frame is not affected and the resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AL589742, BC150775, BY333359
    Consensus CDS
    CCDS88420.1
    UniProtKB/TrEMBL
    A0A286YCX3
    Conserved Domains (3) summary
    smart00431
    Location:48158
    SCAN; leucine rich region
    COG5048
    Location:250502
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:374394
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001251834.1NP_001238763.1  zinc finger protein with KRAB and SCAN domains 8 isoform 3

    See identical proteins and their annotated locations for NP_001238763.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks several exons and its transcription extends past a splice site that is used in variant 1, resulting in a different 3' coding region and 3' UTR compared to variant 1. The resulting isoform (3) is much shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BY333359, CX566615
    Consensus CDS
    CCDS56871.1
    UniProtKB/TrEMBL
    Q78WV9
    Related
    ENSMUSP00000106107.3, ENSMUST00000110481.3
    Conserved Domains (1) summary
    pfam02023
    Location:48133
    SCAN; SCAN domain
  3. NM_139141.4NP_631880.2  zinc finger protein with KRAB and SCAN domains 8 isoform 1

    See identical proteins and their annotated locations for NP_631880.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK032718, AL589742, BY333359
    Consensus CDS
    CCDS26278.1
    UniProtKB/TrEMBL
    Q8BSL0
    Related
    ENSMUSP00000040248.6, ENSMUST00000045228.12
    Conserved Domains (4) summary
    smart00431
    Location:48158
    SCAN; leucine rich region
    cd07765
    Location:233268
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:322574
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:446466
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    21697391..21715284 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247476.2XP_030103336.1  zinc finger protein with KRAB and SCAN domains 8 isoform X2

    UniProtKB/TrEMBL
    A0A286YCX3
    Related
    ENSMUSP00000153171.2, ENSMUST00000224362.2
    Conserved Domains (3) summary
    smart00431
    Location:48158
    SCAN; leucine rich region
    COG5048
    Location:250502
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:374394
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. XM_030247475.1XP_030103335.1  zinc finger protein with KRAB and SCAN domains 8 isoform X1

    UniProtKB/TrEMBL
    Q8BSL0
    Conserved Domains (4) summary
    smart00431
    Location:48158
    SCAN; leucine rich region
    cd07765
    Location:233268
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:322574
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:446466
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. XM_030247477.1XP_030103337.1  zinc finger protein with KRAB and SCAN domains 8 isoform X3

    Conserved Domains (3) summary
    cd07765
    Location:5792
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:146398
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:270290
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. XM_030247474.2XP_030103334.1  zinc finger protein with KRAB and SCAN domains 8 isoform X1

    UniProtKB/TrEMBL
    Q8BSL0
    Conserved Domains (4) summary
    smart00431
    Location:48158
    SCAN; leucine rich region
    cd07765
    Location:233268
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:322574
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:446466
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. XM_036158230.1XP_036014123.1  zinc finger protein with KRAB and SCAN domains 8 isoform X3

    Conserved Domains (3) summary
    cd07765
    Location:5792
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:146398
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:270290
    ZF_C2H2; C2H2 Zn finger [structural motif]