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Zkscan8 zinc finger with KRAB and SCAN domains 8 [ Mus musculus (house mouse) ]

Gene ID: 93681, updated on 4-Nov-2024

Summary

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Official Symbol
Zkscan8provided by MGI
Official Full Name
zinc finger with KRAB and SCAN domains 8provided by MGI
Primary source
MGI:MGI:1913815
See related
Ensembl:ENSMUSG00000063894 AllianceGenome:MGI:1913815
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LD5-1; Zfp192; 2510038J07Rik; D430019P06Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in several structures, including central nervous system; early conceptus; eye; and genitourinary system. Orthologous to human ZKSCAN8 (zinc finger with KRAB and SCAN domains 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in limb E14.5 (RPKM 5.0), whole brain E14.5 (RPKM 3.6) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Zkscan8 in Genome Data Viewer
Location:
13 A3.1; 13 7.84 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (21697391..21715284, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (21513221..21531114, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit 5B, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5373 Neighboring gene zinc finger protein 389 Neighboring gene predicted gene, 32724 Neighboring gene olfactory receptor family 1 subfamily F member 12 Neighboring gene olfactory receptor family 2 subfamily B member 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of SCAN dimerization domains in four gene families. Honer C, et al. Biochim Biophys Acta, 2001 Feb 16. PMID 11342224
  2. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
  3. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
  4. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein with KRAB and SCAN domains 8
Names
zinc finger protein 192

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001251833.1 → NP_001238762.1  zinc finger protein with KRAB and SCAN domains 8 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two consecutive exons in the CDS, compared to variant 1. The reading frame is not affected and the resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AL589742, BC150775, BY333359
    Consensus CDS
    CCDS88420.1
    UniProtKB/TrEMBL
    A0A286YCX3
    Conserved Domains (3) summary
    smart00431
    Location:48 → 158
    SCAN; leucine rich region
    COG5048
    Location:250 → 502
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:374 → 394
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001251834.1 → NP_001238763.1  zinc finger protein with KRAB and SCAN domains 8 isoform 3

    See identical proteins and their annotated locations for NP_001238763.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks several exons and its transcription extends past a splice site that is used in variant 1, resulting in a different 3' coding region and 3' UTR compared to variant 1. The resulting isoform (3) is much shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BY333359, CX566615
    Consensus CDS
    CCDS56871.1
    UniProtKB/TrEMBL
    Q78WV9
    Related
    ENSMUSP00000106107.3, ENSMUST00000110481.3
    Conserved Domains (1) summary
    pfam02023
    Location:48 → 133
    SCAN; SCAN domain

  3. NM_139141.4 → NP_631880.2  zinc finger protein with KRAB and SCAN domains 8 isoform 1

    See identical proteins and their annotated locations for NP_631880.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK032718, AL589742, BY333359
    Consensus CDS
    CCDS26278.1
    UniProtKB/TrEMBL
    Q8BSL0
    Related
    ENSMUSP00000040248.6, ENSMUST00000045228.12
    Conserved Domains (4) summary
    smart00431
    Location:48 → 158
    SCAN; leucine rich region
    cd07765
    Location:233 → 268
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:322 → 574
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:446 → 466
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    21697391..21715284 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247476.2 → XP_030103336.1  zinc finger protein with KRAB and SCAN domains 8 isoform X2

    UniProtKB/TrEMBL
    A0A286YCX3
    Related
    ENSMUSP00000153171.2, ENSMUST00000224362.2
    Conserved Domains (3) summary
    smart00431
    Location:48 → 158
    SCAN; leucine rich region
    COG5048
    Location:250 → 502
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:374 → 394
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_030247475.1 → XP_030103335.1  zinc finger protein with KRAB and SCAN domains 8 isoform X1

    UniProtKB/TrEMBL
    Q8BSL0
    Conserved Domains (4) summary
    smart00431
    Location:48 → 158
    SCAN; leucine rich region
    cd07765
    Location:233 → 268
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:322 → 574
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:446 → 466
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_030247477.1 → XP_030103337.1  zinc finger protein with KRAB and SCAN domains 8 isoform X3

    Conserved Domains (3) summary
    cd07765
    Location:57 → 92
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:146 → 398
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:270 → 290
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. XM_030247474.2 → XP_030103334.1  zinc finger protein with KRAB and SCAN domains 8 isoform X1

    UniProtKB/TrEMBL
    Q8BSL0
    Conserved Domains (4) summary
    smart00431
    Location:48 → 158
    SCAN; leucine rich region
    cd07765
    Location:233 → 268
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:322 → 574
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:446 → 466
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. XM_036158230.1 → XP_036014123.1  zinc finger protein with KRAB and SCAN domains 8 isoform X3

    Conserved Domains (3) summary
    cd07765
    Location:57 → 92
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:146 → 398
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:270 → 290
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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