Format

Send to:

Choose Destination

ZKSCAN8 zinc finger with KRAB and SCAN domains 8 [ Homo sapiens (human) ]

Gene ID: 7745, updated on 23-Nov-2021

Summary

Official Symbol
ZKSCAN8provided by HGNC
Official Full Name
zinc finger with KRAB and SCAN domains 8provided by HGNC
Primary source
HGNC:HGNC:12983
See related
Ensembl:ENSG00000198315 MIM:602240
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LD5-1; ZNF192; ZSCAN40
Expression
Ubiquitous expression in endometrium (RPKM 9.3), ovary (RPKM 8.6) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ZKSCAN8 in Genome Data Viewer
Location:
6p22.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (28141643..28159461)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (28109661..28127238)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene zinc finger protein 602, pseudogene Neighboring gene ZSCAN16 antisense RNA 1 Neighboring gene zinc finger and SCAN domain containing 16 Neighboring gene ZKSCAN8 pseudogene 1 Neighboring gene zinc finger protein 603, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein with KRAB and SCAN domains 8
Names
zinc finger protein 192

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278119.2NP_001265048.1  zinc finger protein with KRAB and SCAN domains 8 isoform 1

    See identical proteins and their annotated locations for NP_001265048.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longest transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AB208793, AL358933, BC096282, BM664529
    Consensus CDS
    CCDS4645.1
    UniProtKB/Swiss-Prot
    Q15776
    UniProtKB/TrEMBL
    A0A024RCK7, Q59HG5
    Related
    ENSP00000402948.2, ENST00000457389.6
    Conserved Domains (4) summary
    smart00431
    Location:47159
    SCAN; leucine rich region
    COG5048
    Location:315564
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:436456
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:221262
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  2. NM_001278121.2NP_001265050.1  zinc finger protein with KRAB and SCAN domains 8 isoform 2

    See identical proteins and their annotated locations for NP_001265050.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate 5' exon and an alternate splice site in the 5' region, which results in translation initiation at a downstream AUG, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Both variants 3 and 4 encode the same isoform (2).
    Source sequence(s)
    AK302402, AL358933, BM664529
    UniProtKB/Swiss-Prot
    Q15776
    Conserved Domains (5) summary
    cd07765
    Location:3371
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:128377
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:249269
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:135157
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:318341
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001278122.2NP_001265051.1  zinc finger protein with KRAB and SCAN domains 8 isoform 2

    See identical proteins and their annotated locations for NP_001265051.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has an alternate splice site in the 5' region, which results in translation initiation at a downstream AUG, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Both variants 3 and 4 encode the same isoform (2).
    Source sequence(s)
    AB208793, AL358933, BM664529
    UniProtKB/TrEMBL
    Q59HG5
    Conserved Domains (5) summary
    cd07765
    Location:3371
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:128377
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:249269
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:135157
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:318341
    zf-H2C2_2; Zinc-finger double domain
  4. NM_006298.4NP_006289.2  zinc finger protein with KRAB and SCAN domains 8 isoform 1

    See identical proteins and their annotated locations for NP_006289.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal exon in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AB208793, AL358933, BC130032, BM664529
    Consensus CDS
    CCDS4645.1
    UniProtKB/Swiss-Prot
    Q15776
    UniProtKB/TrEMBL
    A0A024RCK7, Q59HG5
    Related
    ENSP00000332750.5, ENST00000330236.7
    Conserved Domains (4) summary
    smart00431
    Location:47159
    SCAN; leucine rich region
    COG5048
    Location:315564
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:436456
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:221262
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    28141643..28159461
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017011266.2XP_016866755.1  zinc finger protein with KRAB and SCAN domains 8 isoform X1

    UniProtKB/Swiss-Prot
    Q15776
    UniProtKB/TrEMBL
    A0A024RCK7
    Conserved Domains (4) summary
    smart00431
    Location:47159
    SCAN; leucine rich region
    COG5048
    Location:315564
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:436456
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:221262
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  2. XM_011514873.2XP_011513175.1  zinc finger protein with KRAB and SCAN domains 8 isoform X2

    See identical proteins and their annotated locations for XP_011513175.1

    Conserved Domains (5) summary
    cd07765
    Location:3371
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:128377
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:249269
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:135157
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:318341
    zf-H2C2_2; Zinc-finger double domain
  3. XM_011514870.2XP_011513172.1  zinc finger protein with KRAB and SCAN domains 8 isoform X1

    See identical proteins and their annotated locations for XP_011513172.1

    UniProtKB/Swiss-Prot
    Q15776
    UniProtKB/TrEMBL
    A0A024RCK7
    Conserved Domains (4) summary
    smart00431
    Location:47159
    SCAN; leucine rich region
    COG5048
    Location:315564
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:436456
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:221262
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  4. XM_011514874.2XP_011513176.1  zinc finger protein with KRAB and SCAN domains 8 isoform X2

    See identical proteins and their annotated locations for XP_011513176.1

    Conserved Domains (5) summary
    cd07765
    Location:3371
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:128377
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:249269
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:135157
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:318341
    zf-H2C2_2; Zinc-finger double domain
Support Center