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IGSF8 immunoglobulin superfamily member 8 [ Homo sapiens (human) ]

Gene ID: 93185, updated on 2-Oct-2018

Summary

Official Symbol
IGSF8provided by HGNC
Official Full Name
immunoglobulin superfamily member 8provided by HGNC
Primary source
HGNC:HGNC:17813
See related
Ensembl:ENSG00000162729 MIM:606644; Vega:OTTHUMG00000024075
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EWI2; PGRL; CD316; EWI-2; KCT-4; CD81P3; LIR-D1
Summary
This gene encodes a member the EWI subfamily of the immunoglobulin protein superfamily. Members of this family contain a single transmembrane domain, an EWI (Glu-Trp-Ile)-motif and a variable number of immunoglobulin domains. This protein interacts with the tetraspanins CD81 and CD9 and may regulate their role in certain cellular functions including cell migration and viral infection. The encoded protein may also function as a tumor suppressor by inhibiting the proliferation of certain cancers. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]
Expression
Ubiquitous expression in brain (RPKM 17.6), skin (RPKM 9.6) and 24 other tissues See more
Orthologs

Genomic context

See IGSF8 in Genome Data Viewer
Location:
1q23.2
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (160091339..160099442, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (160061129..160068650, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol glycan anchor biosynthesis class M Neighboring gene potassium voltage-gated channel subfamily J member 10 Neighboring gene potassium voltage-gated channel subfamily J member 9 Neighboring gene ATPase Na+/K+ transporting subunit alpha 2 Neighboring gene ATPase Na+/K+ transporting subunit alpha 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of IGSF8 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell motility NAS
Non-traceable Author Statement
more info
PubMed 
cell proliferation NAS
Non-traceable Author Statement
more info
PubMed 
nervous system development NAS
Non-traceable Author Statement
more info
PubMed 
single fertilization NAS
Non-traceable Author Statement
more info
PubMed 
skeletal muscle tissue development NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
immunoglobulin superfamily member 8
Names
CD81 partner 3
glu-Trp-Ile EWI motif-containing protein 2
keratinocytes-associated transmembrane protein 4
prostaglandin regulatory-like protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030031.1 RefSeqGene

    Range
    5001..12490
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001206665.2NP_001193594.1  immunoglobulin superfamily member 8 precursor

    See identical proteins and their annotated locations for NP_001193594.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK308115, AL121987, BU172537
    Consensus CDS
    CCDS1195.1
    UniProtKB/Swiss-Prot
    Q969P0
    Related
    ENSP00000477565.1, ENST00000614243.4
    Conserved Domains (2) summary
    pfam07686
    Location:28149
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:318419
    Ig; Immunoglobulin domain
  2. NM_001320247.1NP_001307176.1  immunoglobulin superfamily member 8 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AY044845, AY157579, BM544492, BU172537
    Consensus CDS
    CCDS1195.1
    UniProtKB/Swiss-Prot
    Q969P0
    Related
    ENSP00000357065.1, OTTHUMP00000025753, ENST00000368086.5, OTTHUMT00000060636
    Conserved Domains (2) summary
    pfam07686
    Location:28149
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:318419
    Ig; Immunoglobulin domain
  3. NM_052868.5NP_443100.1  immunoglobulin superfamily member 8 precursor

    See identical proteins and their annotated locations for NP_443100.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BC053881, BM544492, BU172537
    Consensus CDS
    CCDS1195.1
    UniProtKB/Swiss-Prot
    Q969P0
    Related
    ENSP00000316664.7, OTTHUMP00000025751, ENST00000314485.11, OTTHUMT00000060634
    Conserved Domains (2) summary
    pfam07686
    Location:28149
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:318419
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    160091339..160099442 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002836.1XP_016858325.1  immunoglobulin superfamily member 8 isoform X1

    UniProtKB/Swiss-Prot
    Q969P0
    Conserved Domains (2) summary
    pfam07686
    Location:28149
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:318419
    Ig; Immunoglobulin domain
  2. XM_017002835.1XP_016858324.1  immunoglobulin superfamily member 8 isoform X1

    UniProtKB/Swiss-Prot
    Q969P0
    Conserved Domains (2) summary
    pfam07686
    Location:28149
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:318419
    Ig; Immunoglobulin domain
  3. XM_017002837.1XP_016858326.1  immunoglobulin superfamily member 8 isoform X1

    UniProtKB/Swiss-Prot
    Q969P0
    Conserved Domains (2) summary
    pfam07686
    Location:28149
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:318419
    Ig; Immunoglobulin domain
  4. XM_024450945.1XP_024306713.1  immunoglobulin superfamily member 8 isoform X2

    Conserved Domains (2) summary
    pfam07686
    Location:11132
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:301402
    Ig; Immunoglobulin domain
  5. XM_006711631.3XP_006711694.1  immunoglobulin superfamily member 8 isoform X2

    Conserved Domains (2) summary
    pfam07686
    Location:11132
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:301402
    Ig; Immunoglobulin domain
  6. XM_024450947.1XP_024306715.1  immunoglobulin superfamily member 8 isoform X3

    Conserved Domains (2) summary
    pfam07686
    Location:6127
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:296397
    Ig; Immunoglobulin domain
  7. XM_017002840.2XP_016858329.1  immunoglobulin superfamily member 8 isoform X3

    Conserved Domains (2) summary
    pfam07686
    Location:6127
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:296397
    Ig; Immunoglobulin domain
  8. XM_017002839.1XP_016858328.1  immunoglobulin superfamily member 8 isoform X3

    Conserved Domains (2) summary
    pfam07686
    Location:6127
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:296397
    Ig; Immunoglobulin domain
  9. XM_017002838.1XP_016858327.1  immunoglobulin superfamily member 8 isoform X3

    Conserved Domains (2) summary
    pfam07686
    Location:6127
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:296397
    Ig; Immunoglobulin domain
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