U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Igsf8 immunoglobulin superfamily, member 8 [ Mus musculus (house mouse) ]

Gene ID: 140559, updated on 3-Jun-2024

Summary

Official Symbol
Igsf8provided by MGI
Official Full Name
immunoglobulin superfamily, member 8provided by MGI
Primary source
MGI:MGI:2154090
See related
Ensembl:ENSMUSG00000038034 AllianceGenome:MGI:2154090
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PGRL; EWI-2; KCT-4; ESTM34
Summary
Acts upstream of or within regulation of cell motility. Located in axon and synapse. Is expressed in several structures, including branchial arch; cardiac muscle tissue; central nervous system; epithelium; and sensory organ. Orthologous to human IGSF8 (immunoglobulin superfamily member 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cortex adult (RPKM 65.6), ovary adult (RPKM 59.1) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Igsf8 in Genome Data Viewer
Location:
1 H3; 1 79.59 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (172139934..172147410)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (172312367..172319843)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene ATPase, Na+/K+ transporting, alpha 4 polypeptide Neighboring gene translocase of inner mitochondrial membrane 23 homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_03056 Neighboring gene predicted gene, 57554 Neighboring gene STARR-positive B cell enhancer mm9_chr1:174207398-174207699 Neighboring gene ATPase, Na+/K+ transporting, alpha 2 polypeptide Neighboring gene predicted gene, 39704 Neighboring gene STARR-positive B cell enhancer ABC_E5853 Neighboring gene STARR-positive B cell enhancer ABC_E11698 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 9 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 10

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in myelin sheath HDA PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
immunoglobulin superfamily member 8
Names
CD81 partner 3
PG regulatory-like protein
glu-Trp-Ile EWI motif-containing protein 2
keratinocyte-associated transmembrane protein 4
prostaglandin regulatory-like protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080419.2NP_536344.1  immunoglobulin superfamily member 8 precursor

    See identical proteins and their annotated locations for NP_536344.1

    Status: VALIDATED

    Source sequence(s)
    AC074311, BC048387, BU059206
    Consensus CDS
    CCDS15511.1
    UniProtKB/Swiss-Prot
    Q8R0L7, Q8R366
    UniProtKB/TrEMBL
    A0A0R4J117
    Related
    ENSMUSP00000041232.10, ENSMUST00000039506.15
    Conserved Domains (2) summary
    smart00410
    Location:33146
    IG_like; Immunoglobulin like
    cl11960
    Location:40147
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    172139934..172147410
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)