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STK17B serine/threonine kinase 17b [ Homo sapiens (human) ]

Gene ID: 9262, updated on 24-Nov-2020

Summary

Official Symbol
STK17Bprovided by HGNC
Official Full Name
serine/threonine kinase 17bprovided by HGNC
Primary source
HGNC:HGNC:11396
See related
Ensembl:ENSG00000081320 MIM:604727
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DRAK2
Expression
Broad expression in bone marrow (RPKM 54.0), lymph node (RPKM 45.0) and 18 other tissues See more
Orthologs

Genomic context

See STK17B in Genome Data Viewer
Location:
2q32.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (196133583..196176503, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (196998307..197036336, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene dynein axonemal heavy chain 7 Neighboring gene E2F transcription factor 3 pseudogene 2 Neighboring gene glutathione S-transferase alpha 5 pseudogene Neighboring gene uncharacterized LOC101927454 Neighboring gene HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 Neighboring gene HECW2 antisense RNA 1 Neighboring gene RNA, 7SL, cytoplasmic 820, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of fibroblast apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum-Golgi intermediate compartment IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase 17B
Names
DAP kinase-related apoptosis-inducing protein kinase 2
death-associated protein kinase-related 2
NP_004217.1
XP_011510470.1
XP_011510471.1
XP_011510472.1
XP_011510473.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004226.4NP_004217.1  serine/threonine-protein kinase 17B

    See identical proteins and their annotated locations for NP_004217.1

    Status: VALIDATED

    Source sequence(s)
    AC114760, BM994696
    Consensus CDS
    CCDS2315.1
    UniProtKB/Swiss-Prot
    O94768
    UniProtKB/TrEMBL
    Q53QE7
    Related
    ENSP00000263955.4, ENST00000263955.9
    Conserved Domains (1) summary
    cd14198
    Location:24293
    STKc_DRAK2; The catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related Apoptosis-inducing protein Kinase 2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    196133583..196176503 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512169.1XP_011510471.1  serine/threonine-protein kinase 17B isoform X1

    See identical proteins and their annotated locations for XP_011510471.1

    UniProtKB/Swiss-Prot
    O94768
    UniProtKB/TrEMBL
    Q53QE7
    Related
    ENSP00000386853.1, ENST00000409228.5
    Conserved Domains (1) summary
    cd14198
    Location:24293
    STKc_DRAK2; The catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related Apoptosis-inducing protein Kinase 2
  2. XM_011512170.1XP_011510472.1  serine/threonine-protein kinase 17B isoform X1

    See identical proteins and their annotated locations for XP_011510472.1

    UniProtKB/Swiss-Prot
    O94768
    UniProtKB/TrEMBL
    Q53QE7
    Conserved Domains (1) summary
    cd14198
    Location:24293
    STKc_DRAK2; The catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related Apoptosis-inducing protein Kinase 2
  3. XM_011512168.3XP_011510470.1  serine/threonine-protein kinase 17B isoform X1

    See identical proteins and their annotated locations for XP_011510470.1

    UniProtKB/Swiss-Prot
    O94768
    UniProtKB/TrEMBL
    Q53QE7
    Conserved Domains (1) summary
    cd14198
    Location:24293
    STKc_DRAK2; The catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related Apoptosis-inducing protein Kinase 2
  4. XM_011512171.2XP_011510473.1  serine/threonine-protein kinase 17B isoform X2

    See identical proteins and their annotated locations for XP_011510473.1

    Conserved Domains (2) summary
    smart00220
    Location:3165
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1165
    PKc_like; Protein Kinases, catalytic domain
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